Hypoxia-regulated neurotrophin-3 expression by multicopy hypoxia response elements reduces apoptosis in PC12 cells

A BeenkenM MohammadiThe FGF family: biology, pathophysiology and therapyNat Rev Drug Discov8235253200910.1038/nrd279219247306

RJ LeeML SpringerWE Blanco-BoseR ShawPC UrsellHM BlauVEGF gene delivery to myocardium: deleterious effects of unregulated expressionCirculation102898901200010.1161/01.CIR.102.8.89810952959

Q ShiP ZhangJ ZhangAdenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in miceNeurosci Lett465220225200910.1016/j.neulet.2009.08.049

F ShenH SuY FanAdeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in miceStroke3726012606200610.1161/01.STR.0000240407.14765.e8

T ShibataAJ GiacciaJM BrownDevelopment of a hypoxia-responsive vector for tumor-specific gene therapyGene Ther7493498200010.1038/sj.gt.330112410757022

H SuJ Arakawa-HoytYW KanAdeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart modelProc Natl Acad Sci USA9994809485200210.1073/pnas.13227529912084814

GL SemenzaTargeting HIF-1 for cancer therapyNat Rev Cancer3721732200310.1038/nrc1187

NV IyerLE KotchF AganiCellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1 alphaGenes Dev1214916219989436976

A PatapoutianLF ReichardtTrk receptors: mediators of neurotrophin actionCurr Opin Neurobiol11272280200110.1016/S0959-4388(00)00208-711399424

X LiZ YangA ZhangThe effect of neurotrophin-3/chitosan carriers on the proliferation and differentiation of neural stem cellsBiomaterials3049784985200910.1016/j.biomaterials.2009.05.04719539985

H LuM LiT SongRetrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitroBrain Res Bull77158164200810.1016/j.brainresbull.2008.02.03719875351

HX LuZM HaoQ JiaoNeurotrophin-3 gene transduction of mouse neural stem cells promotes proliferation and neuronal differentiation in organotypic hippocampal slice culturesMed Sci Monit17BR305BR311201122037732

ZH ZhangRZ WangGL LiTransplantation of neural stem cells modified by human neurotrophin-3 promotes functional recovery after transient focal cerebral ischemia in ratsNeurosci Lett444227230200810.1016/j.neulet.2008.08.049

B CristofaroOA StoneA CaporaliNeurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemiaArterioscler Thromb Vasc Biol3011431150201010.1161/ATVBAHA.109.20546820360537

K ShimazuM ZhaoK SakataNT-3 facilitates hippo-campal plasticity and learning and memory by regulating neurogenesisLearn Mem13307315200610.1101/lm.7600616705139

T ShibataAJ GiacciaJM BrownHypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapyNeoplasia44048200210.1038/sj.neo.790018911922390

H RuanH SuL HuKR LambornYW KanDF DeenA hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapyNeoplasia3255263200110.1038/sj.neo.790015711494119

N MoriR SteinO SigmundDJ AndersonA cell type-preferred silencer element that controls the neural-specific expression of the SCG10 geneNeuron4583594199010.1016/0896-6273(90)90116-W2322462

D HuangA DesboisST HouA novel adenoviral vector which mediates hypoxia-inducible gene expression selectively in neuronsGene Ther1213691376200510.1038/sj.gt.3302538

HW HuXK LiRY ZhengJ XiaoJQ ZengST HoubFGF expression mediated by a hypoxia-regulated adenoviral vector protects PC12 cell death induced by serum deprivationBiochem Biophys Res Commun390115120200910.1016/j.bbrc.2009.09.07719782044

JA HillionK TakahashiD MaricC RuetzlerJL BarkerJM HallenbeckDevelopment of an ischemic tolerance model in a PC12 cell lineJ Cereb Blood Flow Metab25154162200510.1038/sj.jcbfm.960000315647748

I SilverM ErecinskaOxygen and ion concentrations in normoxic and hypoxic brain cellsAdv Exp Med Biol454716199810.1007/978-1-4615-4863-8_29889871

SJ RiedlY ShiMolecular mechanisms of caspase regulation during apoptosisNat Rev Mol Cell Biol5897907200410.1038/nrm149615520809

C MoriscoC MarroneV TrimarcoInsulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expressionCardiovasc Res76453464200710.1016/j.cardiores.2007.07.01217698050

G LiotC GabrielM CacquevelNeurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosisExp Neurol1873846200410.1016/j.expneurol.2004.01.00215081586