Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December 2012 Volume 30 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2012 Volume 30 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways

  • Authors:
    • Hye Won Eom
    • Sun Young Park
    • Young Hun Kim
    • Su Jin Seong
    • Mei Ling Jin
    • Eun Yeon Ryu
    • Min Ju Kim
    • Sang Joon Lee
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Pusan National University, Busan, Republic of Korea, Bio-IT Fusion Technology Research Institute, Pusan National University, Busan, Republic of Korea
  • Pages: 1512-1520
    |
    Published online on: September 18, 2012
       https://doi.org/10.3892/ijmm.2012.1128
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recent evidence indicates that microglial activation and hippocampal damage may play important roles in neurodegenerative diseases, including Alzheimer's disease. Bambusae Caulis in Taeniam has been used as a folk remedy for the treatment of hypertension and cardiovascular disease in China and Korea. In this study, the mechanism responsible for the neuroprotective and anti-neuroinflammatory effects of Bambusae Caulis in Taeniam ethyl acetate fraction (BCE) was investigated. Heme oxygenase-1 (HO-1) is an inducible enzyme expressed in response to various inflammatory stimuli. Due to its role in the anti-inflammatory signaling pathway, the expression and modulation of HO-1 are important. In this study, the neuroprotective and anti-neuroinflammatory effects of BCE were examined using the murine microglial BV2 and hippocampal HT22 cells. We demonstrated that the administration of BCE provided neuroprotective effects against glutamate-induced cytotoxicity in HT22 cells through the HO-1 and nuclear erythroid-2 related factor 2 (Nrf-2) signaling pathways. We also reported that BCE inhibited lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and that the presence of selective inhibitors of HO-1 (SnPP) resulted in the inhibition of BCE-mediated anti-inflammatory activity in BV2 microglial cells. BCE was shown to induce HO-1 expression as well as the nuclear translocation of Nrf-2 in both microglial and hippocampal cells. These findings revealed the potential therapeutic mechanisms of BCE in neurodegenerative diseases, suggesting that HO-1 and Nrf-2 signaling may play important roles in the mediation of its neuroprotective and anti-neuroinflammatory effects.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1. 

DJ SelkoeThe molecular pathology of Alzheimer’s diseaseNeuron64874981991

2. 

J VinaA LloretE GiraldoMC BadiaMD AlonsoAntioxidant pathways in Alzheimer’s disease: possibilities of interventionCurr Pharm Des17386138642011

3. 

ST DheenC KaurEA LingMicroglial activation and its implications in the brain diseasesCurr Med Chem1411891197200710.2174/09298670778059796117504139

4. 

VH PerryThe influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative diseaseBrain Behav Immun18407413200410.1016/j.bbi.2004.01.00415265532

5. 

GS JeongDS LeeTO KwonHS LeeRB AnYC KimCytoprotective constituents of the heartwood of Caesalpinia sappan on glutamate-induced oxidative damage in HT22 cellsBiol Pharm Bull32945949200919420770

6. 

TH MurphyM MiyamotoA SastreRL SchnaarJT CoyleGlutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stressNeuron215471558198910.1016/0896-6273(89)90043-32576375

7. 

T NguyenP NioiCB PickettThe Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressJ Biol Chem2841329113295200910.1074/jbc.R90001020019182219

8. 

T JiangZ HuangJY ChanDD ZhangNrf2 protects against As(III)-induced damage in mouse liver and bladderToxicol Appl Pharmacol240814200910.1016/j.taap.2009.06.01019538980

9. 

W LiAN KongMolecular mechanisms of Nrf2-mediated antioxidant responseMol Carcinog4891104200910.1002/mc.20465

10. 

MD MainesThe heme oxygenase system: a regulator of second messenger gasesAnnu Rev Pharmacol Toxicol37517554199710.1146/annurev.pharmtox.37.1.5179131263

11. 

HM SchipperHeme oxygenase-1 in Alzheimer disease: a tribute to Moussa YoudimJ Neural Transm118381387201110.1007/s00702-010-0436-120563825

12. 

HM SchipperW SongH ZukorJR HascaloviciD ZeligmanHeme oxygenase-1 and neurodegeneration: expanding frontiers of engagementJ Neurochem110469485200910.1111/j.1471-4159.2009.06160.x19457088

13. 

HM SchipperHeme oxygenase expression in human central nervous system disordersFree Radic Biol Med3719952011200410.1016/j.freeradbiomed.2004.09.015

14. 

M ShibataY YamatakeM SakamotoM KanamoriK TakagiPhamacological studies on bamboo grass (1). Acute toxicity and anti-inflammatory and antiulcerogenic activities of water-soluble fraction (Folin) extracted from Sasa albomarginata Makino et ShibataNihon Yakurigaku Zasshi714814901975(In Japanese)

15. 

GC BrownJJ NeherInflammatory neurodegeneration and mechanisms of microglial killing of neuronsMol Neurobiol41242247201010.1007/s12035-010-8105-920195798

16. 

DH ShinJY ShinSH KimJH KimHJ ChungJC KimSingle oral dose toxicity study of Bambusae caulis in Taeniam in ratsJ Toxicol and Public Health203253282004(In Korean)

17. 

Y NakamuraQS SiK KataokaLipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxideNeurosci Res3595100199910.1016/S0168-0102(99)00071-1

18. 

J LiuL LiWZ SuoHT22 hippocampal neuronal cell line possesses functional cholinergic propertiesLife Sci84267271200910.1016/j.lfs.2008.12.00819135458

19. 

L MedaMA CassatellaGI SzendreiL Otvos JrP BaronM VillalbaD FerrariF RossiActivation of microglial cells by beta-amyloid protein and interferon-gammaNature374647650199510.1038/374647a07715705

20. 

J FangH QinT SekiH NakamuraK TsukigawaT ShinH MaedaTherapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury modelJ Pharmacol Exp Ther339779789201110.1124/jpet.111.185348

21. 

KA JungMK KwakThe Nrf2 system as a potential target for the development of indirect antioxidantsMolecules1572667291201010.3390/molecules1510726620966874

22. 

PA DenneryRegulation and role of heme oxygenase in oxidative injuryCurr Top Cell Regul36181199200010.1016/S0070-2137(01)80008-X10842752

23. 

YJ SurhJK KunduMH LiHK NaYN ChaRole of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stressArch Pharm Res3211631176200910.1007/s12272-009-1807-819727608

24. 

T Ben-HurO Ben-MenachemV FurerO EinsteinR Mizrachi-KolN GrigoriadisEffects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cellsMol Cell Neurosci24623631200310.1016/S1044-7431(03)00218-514664813

25. 

CT EkdahlJH ClaasenS BondeZ KokaiaO LindvallInflammation is detrimental for neurogenesis in adult brainProc Natl Acad Sci USA1001363213637200310.1073/pnas.223403110014581618

26. 

T SeoS ChaTI KimJS LeeKM WooPorphyromonas gingivalis-derived lipopolysaccharide-mediated activation of MAPK signaling regulates inflammatory response and differentiation in human periodontal ligament fibroblastsJ Microbiol50311319201210.1007/s12275-012-2146-x

27. 

J RaS LeeHJ KimYP JangH AhnJ KimBambusae Caulis in Taeniam extract reduces ovalbumin-induced airway inflammation and T helper 2 responses in miceJ Ethnopharmacol128241247201010.1016/j.jep.2010.01.023

28. 

KJ DaviesOxidative stress: the paradox of aerobic lifeBiochem Soc Symp6113119958660387

29. 

H MaedaT AkaikeOxygen free radicals as pathogenic molecules in viral diseasesProc Soc Exp Biol Med198721727199110.3181/00379727-198-43309C1656471

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Eom HW, Park SY, Kim YH, Seong SJ, Jin ML, Ryu EY, Kim MJ and Lee SJ: Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. Int J Mol Med 30: 1512-1520, 2012.
APA
Eom, H.W., Park, S.Y., Kim, Y.H., Seong, S.J., Jin, M.L., Ryu, E.Y. ... Lee, S.J. (2012). Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. International Journal of Molecular Medicine, 30, 1512-1520. https://doi.org/10.3892/ijmm.2012.1128
MLA
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30.6 (2012): 1512-1520.
Chicago
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30, no. 6 (2012): 1512-1520. https://doi.org/10.3892/ijmm.2012.1128
Copy and paste a formatted citation
x
Spandidos Publications style
Eom HW, Park SY, Kim YH, Seong SJ, Jin ML, Ryu EY, Kim MJ and Lee SJ: Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. Int J Mol Med 30: 1512-1520, 2012.
APA
Eom, H.W., Park, S.Y., Kim, Y.H., Seong, S.J., Jin, M.L., Ryu, E.Y. ... Lee, S.J. (2012). Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways. International Journal of Molecular Medicine, 30, 1512-1520. https://doi.org/10.3892/ijmm.2012.1128
MLA
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30.6 (2012): 1512-1520.
Chicago
Eom, H. W., Park, S. Y., Kim, Y. H., Seong, S. J., Jin, M. L., Ryu, E. Y., Kim, M. J., Lee, S. J."Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways". International Journal of Molecular Medicine 30, no. 6 (2012): 1512-1520. https://doi.org/10.3892/ijmm.2012.1128
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team