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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2012 Volume 30 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Elucidating the regulation of T cell subsets (Review)

Yasuko Kitagishi, Mayumi Kobayashi, Yurie Yamashina, Satoru Matsuda
Pages: 1255-1260
Published online on: 09 October 2012

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Review

GPR40: A therapeutic target for mediating insulin secretion (Review)

Xiao-Tao Feng, Jing Leng, Zhen Xie, Shuang-Lei Li, Wei Zhao, Qian-Li Tang
Pages: 1261-1266
Published online on: 26 September 2012

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Article Open Access

Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer

Dong Hua, Li Shen, Lan Xu, Zhi Jiang, Yinghui Zhou, Aihuan Yue, Shitao Zou, Zhihong Cheng, Shiliang Wu
Pages: 1267-1274
Published online on: 18 September 2012

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Article Open Access

Possible role of transforming growth factor-β1 and vascular endothelial growth factor in Fabry disease nephropathy

Mi Hee Lee, Eun Nam Choi, Yeo Jin Jeon, Sung-Chul Jung
Pages: 1275-1280
Published online on: 24 September 2012

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Article Open Access

RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis

Naoko Yagishita, Satoko Aratani, Craig Leach, Tetsuya Amano, Yoshihisa Yamano, Ko Nakatani, Kusuki Nishioka, Toshihiro Nakajima
Pages: 1281-1286
Published online on: 18 September 2012

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Article Open Access

Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney

Takahiro Fujimoto, Senji Shirasawa
Pages: 1287-1293
Published online on: 17 September 2012

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Article

Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury

Yaqin Wu, Junjie Lv, Dongjie Feng, Feng Jiang, Xiaohu Fan, Zhi Zhang, Rong Yin, Lin Xu
Pages: 1294-1306
Published online on: 16 October 2012

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Article

Arginine inactivates human herpesvirus 2 and inhibits genital herpesvirus infection

Keiko Ikeda, Hisashi Yamasaki, Sawako Minami, Yukiko Suzuki, Kazuko Tsujimoto, Yoshihisa Sekino, Hiroshi Irie, Tsutomu Arakawa, A. Hajime Koyama
Pages: 1307-1312
Published online on: 04 October 2012

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Article

Hyperglycemia suppresses cardiac stem cell homing to peri-infarcted myocardium via regulation of ERK1/2 and p38 MAPK activities

Tonghui She, Xiaoyan Wang, Yaping Gan, Dong Kuang, Junqiu Yue, Juan Ni, Xia Zhao, Guoping Wang
Pages: 1313-1320
Published online on: 11 September 2012

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Article

microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma

Xu-Chao Zhu, Qiong-Zhu Dong, Xiao-Fei Zhang, Biao Deng, Hu-Liang Jia, Qin-Hai Ye, Lun-Xiu Qin, Xing-Zhong Wu
Pages: 1321-1326
Published online on: 25 September 2012

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Article

Comparative study of the osteogenic differentiation capacity of human bone marrow- and human adipose-derived stem cells under cyclic tensile stretch using quantitative analysis

Yaping Ye, Yu Du, Fengjing Guo, Chen Gong, Kaixiang Yang, Liang Qin
Pages: 1327-1334
Published online on: 07 September 2012

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Article

Prophylactic and therapeutic efficacy of an attenuated Listeria monocytogenes-based vaccine delivering HPV16 E7 in a mouse model

Yanyan Jia, Yuelan Yin, Feifei Duan, Hong Fu, Maozhi Hu, Yunfei Gao, Zhiming Pan, Xinan Jiao
Pages: 1335-1342
Published online on: 20 September 2012

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Article

Construction and characterization of a eukaryotic expression vector for small interfering RNA targeting the NEDD9 gene

Jing-Xia Chang, Hua-Qi Wang, Guo-Qiang Zhao, He-Ying Chu, Guo-Jun Zhang
Pages: 1343-1348
Published online on: 20 September 2012

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Article

Centella asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes

In-Sook An, Sungkwan An, Tae-Βoo Choe, Sang-Μo Kang, Jae Ho Lee, In-Chul Park, Young-Woo Jin, Su-Jae Lee, Seunghee Bae
Pages: 1349-1356
Published online on: 15 October 2012

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Article

Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation

Ji Hoon Jang, Eun Sun Yang, Kyoung-Jin Min, Taeg Kyu Kwon
Pages: 1357-1364
Published online on: 15 October 2012

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Article

Inhibition of cardiac hypertrophy by probiotic-fermented purple sweet potato yogurt in spontaneously hypertensive rat hearts

Pei-Pei Lin, You-Miin Hsieh, Wei-Wen Kuo, Chien-Chung Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Chih-Yang Huang, Cheng-Chih Tsai
Pages: 1365-1375
Published online on: 12 October 2012

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Article

Transient prehypertensive treatment in spontaneously hypertensive rats: A comparison of losartan and amlodipine regarding long-term blood pressure, cardiac and renal protection

Feng Peng, Jinxiu Lin, Liming Lin, Hong Tang
Pages: 1376-1386
Published online on: 09 October 2012

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Article

Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients

Haruhiko Tokuda, Kenji Kato, Senji Kasahara, Rie Matsushima-Nishiwaki, Takahiko Mizuno, Seiko Sakakibara, Osamu Kozawa
Pages: 1387-1395
Published online on: 01 October 2012

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Article

Expression of aldosterone synthase and adrenocorticotropic hormone receptor in adrenal incidentalomas from normotensive and hypertensive patients: Distinguishing subclinical or atypical primary aldosteronism from adrenal incidentaloma

C. X. Cao, X. C. Yang, Y. X. Gao, M. Zhuang, K. P. Wang , L. J. Sun, X. S. Wang
Pages: 1396-1402
Published online on: 27 September 2012

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Article

Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer

Junfen Ma, Jimin Zhao, Jing Lu, Yanan Jiang, Hongyan Yang, Pei Li, Mingyao Zhao, Kangdong Liu, Ziming Dong
Pages: 1403-1409
Published online on: 19 September 2012

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Article

Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1

Shuangsheng Huang, Ninggang Yang, Yuanyuan Liu, Jing Gao, Tao  Huang, Lamei Hu, Jin Zhao, Yongquan Li, Caili Li, Xiaosu Zhang
Pages: 1410-1416
Published online on: 01 October 2012

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Article

MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model

Desheng Chen, Xianlong Zhang, Yongyuan Guo, Sifeng Shi, Xin Mao, Xiaoyun Pan, Tao Cheng
Pages: 1417-1423
Published online on: 01 October 2012

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Article

Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal

Libo Zheng, Xiuli Chen, Jinbo Guo, Huicong Sun, Lei Liu, David Q. Shih, Xiaolan Zhang
Pages: 1424-1430
Published online on: 05 October 2012

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Article

Sodium butyrate restores ASC expression and induces apoptosis in LS174T cells

Shuai Zhang, Jingqiao Bai, Shuangyi Ren, Ran Wang, Li Zhang, Yunfei Zuo
Pages: 1431-1437
Published online on: 15 October 2012

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Article

Mutations in different regions of the genome of hepatitis C virus genotype 1b and association with response to interferon therapy

Lin Zhang, Feng Han, Dan Zhang, Xiao-Guang Dou
Pages: 1438-1442
Published online on: 15 October 2012

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Article

HBV promotes the proliferation of hepatic stellate cells via the PDGF-B/PDGFR-β signaling pathway in vitro

Qixuan Bai, Jing An, Xiaoning Wu, Hong You, Hong Ma, Tianhui Liu, Na Gao, Jidong Jia
Pages: 1443-1450
Published online on: 04 October 2012

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Article

Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes

Myung-Hee Moon, Jae-Kyo Jeong, You-Jin Lee, Jae-Won Seol, Sang-Youel Park
Pages: 1451-1458
Published online on: 19 September 2012

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Article

Involvement of the WNT and FGF signaling pathways in non-isolated anorectal malformations: Sequencing analysis of WNT3A, WNT5A, WNT11, DACT1, FGF10, FGFR2 and the T gene

Markus Draaken, Wiebke Prins, Claudia Zeidler, Alina Hilger, Sadaf S. Mughal, Jeanette Latus, Thomas M. Boemers, Dominik Schmidt, Eberhard Schmiedeke, Nicole Spychalski, Enrika Bartels, Markus M. Nöthen, Heiko Reutter, Michael Ludwig
Pages: 1459-1464
Published online on: 07 September 2012

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Article

Hexane extract from Uncaria sinensis exhibits anti-apoptotic properties against glutamate-induced neurotoxicity in primary cultured cortical neurons

Ji-Yeon Jang, Ha-Neui Kim, Yu-Ri Kim, Jin-Woo Hong, Young-Whan Choi, Yung-Hyun Choi, Hwa-Kyoung Shin, Byung-Tae Choi
Pages: 1465-1472
Published online on: 19 September 2012

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Article

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1

Andreea M. Bujor, Paul Haines, Cristina Padilla, Romy B. Christmann, Monica Junie, Percival D. Sampaio-Barros, Robert Lafyatis, Maria Trojanowska
Pages: 1473-1480
Published online on: 05 October 2012

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Article

Suppression of lung cancer metastasis-related protein 1 promotes apoptosis in lung cancer cells

Yang Xu, Chunsun Li, Qing Tian, Yanqin Li, Zhen Yang, Zhixin Liang, Liangan Chen
Pages: 1481-1486
Published online on: 16 October 2012

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Article

AMP-activated protein kinase inhibitor decreases prostaglandin F2α-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts

Akira Kondo, Takanobu Otsuka, Kenji Kato, Hideo Natsume, Gen Kuroyanagi, Jun Mizutani, Yoshiki Ito, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 1487-1492
Published online on: 15 October 2012

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Article

Regulation of mammalian MOR-1 gene expression after chronic treatment with morphine

Rose V. Prenus, Ebens Luscar, Zhi-Ping Zhu, Ramesh B. Badisa, Carl B. Goodman
Pages: 1493-1497
Published online on: 19 September 2012

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Article

Impairment of the retinoic acid-inducible gene-I-IFN-β signaling pathway in chronic hepatitis B virus infection

Gangde Zhao, Baoyan An, Huijuan Zhou, Hui Wang, Yumin Xu, Xiaogang Xiang, Zhixia Dong, Fangmei An, Dongshan Yu, Weijing Wang, Shisan Bao, Qing Xie
Pages: 1498-1504
Published online on: 19 September 2012

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Article

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor

Steven G. Gray, Anne-Marie Baird, Fardod O'Kelly, Georgios Nikolaidis, Malin Almgren, Armelle Meunier, Eilis Dockry, Donal Hollywood, Tomas J. Ekström, Antoinette S. Perry, Kenneth J. O'Byrne
Pages: 1505-1511
Published online on: 21 September 2012

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Article

Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways

Hye Won Eom, Sun Young Park, Young Hun Kim, Su Jin Seong, Mei Ling Jin, Eun Yeon Ryu, Min Ju Kim, Sang Joon Lee
Pages: 1512-1520
Published online on: 18 September 2012

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Article

Proteomic analysis of changes in protein expression in serum from animals exposed to paraquat

Yong-Sik Kim, Hana Jung, Hyo-Wook Gil, Sae-Yong Hong, Ho-Yeon Song
Pages: 1521-1527
Published online on: 27 September 2012

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Article

Short- and long-term effects of various Citrullus colocynthis seed extracts in normal and streptozotocin-induced diabetic rats

Nabila Benariba, Rabeh Djaziri, Bouchra Hanane Zerriouh, Wafaa Bellakhdar, Emeline Hupkens, Zahia Boucherit, Willy J. Malaisse
Pages: 1528-1536
Published online on: 18 September 2012

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Article

Stromal cell-derived factor-1α and macrophage migration-inhibitory factor induce metastatic behavior in CXCR4-expressing colon cancer cells

Han-Na Shin, Hyun-Hye Moon, Ja-Lok Ku
Pages: 1537-1543
Published online on: 25 September 2012

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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Retraction Open Access

[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Article Open Access

Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Article Open Access

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Article Open Access

Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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Article Open Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Article Open Access

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Article Open Access

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Review Open Access

Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Review Open Access

Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Review Open Access

Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Review Open Access

Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Review Open Access

Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Article Open Access

Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Review Open Access

Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Article Open Access

Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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August-2026 Volume 58 Issue 2

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Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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