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International Journal of Molecular Medicine
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Article

Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction

  • Authors:
    • Yang-Gyu Park
    • Jae-Kyo Jeong
    • Ju-Hee Lee
    • You-Jin Lee
    • Jae-Won Seol
    • Shang-Jin Kim
    • Tai-Young Hur
    • Young-Hun Jung
    • Seog-Jin Kang
    • Sang-Youel Park
  • View Affiliations / Copyright

    Affiliations: Korea Zoonoses Research Institute, Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea, National Institute of Animal Science, Rural Development Administration, Cheonan, Chungnam 330-801, Republic of Korea
  • Pages: 325-330
    |
    Published online on: November 29, 2012
       https://doi.org/10.3892/ijmm.2012.1198
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Abstract

Prion disorder-related neurodegenerative diseases are characterized by the accumulation of prion protein (PrP) scrapie isoform (PrPsc) within the central nervous system. PrPsc induces neuronal cell death by increasing intracellular generation of reactive oxygen species (ROS). Lactoferrin (LF) is an 80 kDa protein, which has antioxidant abilities due to the scavenging of ROS. The effects of LF treatment on PrP (106-126)-mediated neurotoxicity and ROS generation were the focus of this study. LF treatment protected against PrP (106-126)-induced neuronal cell death and decreased ROS generation. The reduced ROS generation prevented PrP (106-126)-induced mitochondrial dysfunction. Moreover, PrP (106-126)-induced protein activation including c-Jun N-terminal kinase and caspase-3 were blocked by LF treatment. These results demonstrated that LF protects neuronal cells against PrP (106-126)-mediated neurotoxicity through the scavenging of ROS and provide evidence that LF treatment prevents neuronal cell death caused by PrP (106-126).
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Copy and paste a formatted citation
Spandidos Publications style
Park Y, Jeong J, Lee J, Lee Y, Seol J, Kim S, Hur T, Jung Y, Kang S, Park S, Park S, et al: Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. Int J Mol Med 31: 325-330, 2013.
APA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S. ... Park, S. (2013). Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. International Journal of Molecular Medicine, 31, 325-330. https://doi.org/10.3892/ijmm.2012.1198
MLA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31.2 (2013): 325-330.
Chicago
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31, no. 2 (2013): 325-330. https://doi.org/10.3892/ijmm.2012.1198
Copy and paste a formatted citation
x
Spandidos Publications style
Park Y, Jeong J, Lee J, Lee Y, Seol J, Kim S, Hur T, Jung Y, Kang S, Park S, Park S, et al: Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. Int J Mol Med 31: 325-330, 2013.
APA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S. ... Park, S. (2013). Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. International Journal of Molecular Medicine, 31, 325-330. https://doi.org/10.3892/ijmm.2012.1198
MLA
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31.2 (2013): 325-330.
Chicago
Park, Y., Jeong, J., Lee, J., Lee, Y., Seol, J., Kim, S., Hur, T., Jung, Y., Kang, S., Park, S."Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction". International Journal of Molecular Medicine 31, no. 2 (2013): 325-330. https://doi.org/10.3892/ijmm.2012.1198
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