Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
February 2013 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 2013 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs

  • Authors:
    • Xiao-Cheng Wu
    • Bo Huang
    • Jian Wang
    • Chang-Qing Li
    • Yue Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing, P.R. China
  • Pages: 430-436
    |
    Published online on: December 19, 2012
       https://doi.org/10.3892/ijmm.2012.1219
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Parathyroid hormone-related peptide (PTHrP) is an important inductive factor during chondrogenesis of mesenchymal stem cells (MSCs). PTHrP induces chondrogenesis and suppresses hypertrophy, yet the lack of an efficient delivery system limits its use for cartilage tissue engineering in clinical application. In this study, a peptide of 7 amino acids was first used to engineer PTHrP to construct a collagen-targeting system. This peptide functioned as a collagen-binding domain (CBD) to specially target the PTHrP to collagen. ELISA assay was used to determine the collagen-binding ability of CBD-PTHrP. The effect of CBD-PTHrP on chondrogenesis was measured by an in vitro pellet assay in bone marrow-derived MSCs (BM-MSCs). As expected, the CBD peptide promoted the binding of CBD-PTHrP to collagen when compared to NAT-PTHrP. Furthermore, the recombinant protein CBD-PTHrP induced the expression of COL2A1 and Sox-9, inhibited the expression of COL1A1 at the mRNA and protein levels as effectively as NAT-PTHrP. Safranin-O and immunohistochemistry for collagen types Ⅰ, Ⅱ, Ⅹ and Sox-9 generally paralleled qRT-PCR and western blotting findings with minor variations. In conclusion, our study demonstrated that CBD-PTHrP is a collagen-targeting system and promotes in vitro chondrogenesis in BM-MSCs. We suggest that this is an efficient delivery system for cartilage tissue engineering in clinical application.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1. 

Cremer MA, Rosloniec EF and Kang AH: The cartilage collagens: a review of heir structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. J Mol Med. 76:275–288. 1998. View Article : Google Scholar : PubMed/NCBI

2. 

Madry H, van Dijk CN and Mueller-Gerbl M: The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc. 18:419–433. 2010. View Article : Google Scholar : PubMed/NCBI

3. 

Jackson DW, Simon TM and Aberman HM: Symptomatic articular cartilage degeneration: the impact in the new millennium. Clin Orthop Relat Res. (Suppl): S14–S25. 2001. View Article : Google Scholar : PubMed/NCBI

4. 

Gomoll AH, Farr J, Gillogly SD, Kercher JS and Minas T: Surgical management of articular cartilage defects of the knee. Instr Course Lect. 60:461–483. 2011.PubMed/NCBI

5. 

Agnesi F, Amrami KK, Frigo CA and Kaufman KR: Comparison of cartilage thickness with radiologic grade of knee osteoarthritis. Skeletal Radiol. 37:639–643. 2008. View Article : Google Scholar : PubMed/NCBI

6. 

Bae WC, Temple MM, Amiel D, Coutts RD, Niederauer GG and Sah RL: Indentation testing of human cartilage: sensitivity to articular surface degeneration. Arthritis Rheum. 48:3382–3394. 2003. View Article : Google Scholar : PubMed/NCBI

7. 

Magnussen RA, Dunn WR, Carey JL and Spindler KP: Treatment of focal articular cartilage defects in the knee: a systematic review. Clin Orthop Relat Res. 466:952–962. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Cucchiarini M and Madry H: Gene therapy for cartilage defects. J Gene Med. 7:1495–1509. 2005. View Article : Google Scholar : PubMed/NCBI

9. 

Charbord P: Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther. 21:1045–1056. 2010. View Article : Google Scholar : PubMed/NCBI

10. 

Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

11. 

Grogan SP, Miyaki S, Asahara H, D’Lima DD and Lotz MK: Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther. 11:R852009. View Article : Google Scholar : PubMed/NCBI

12. 

Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X and Miosge N: Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell. 4:324–335. 2009. View Article : Google Scholar

13. 

Barry F, Boynton RE, Liu B and Murphy JM: Chondrogenic differentiation of mesenchymal stem cells from bone marrow; differentiation-dependent gene expression of matrix components. Exp Cell Res. 268:189–200. 2001. View Article : Google Scholar : PubMed/NCBI

14. 

Pelttari K, Winter A, Steck E, et al: Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum. 54:3254–3266. 2006. View Article : Google Scholar

15. 

Kim YJ, Kim HJ and Im GI: PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs. Biochem Biophys Res Commun. 373:104–108. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Suva LJ, Winslow GA, Wettenhall RE, et al: A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science. 237:893–896. 1987. View Article : Google Scholar : PubMed/NCBI

17. 

Kronenberg HM: PTHrP and skeletal development. Ann NY Acad Sci. 1068:1–13. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

Kobayashi T, Soegiarto DW, Yang Y, et al: Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 115:1734–1742. 2005. View Article : Google Scholar

19. 

Huang W, Chung UI, Kronenberg HM and de Crombrugghe B: The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci USA. 98:160–165. 2001. View Article : Google Scholar : PubMed/NCBI

20. 

Amling M, Neff L, Tanaka S, et al: Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol. 136:205–213. 1997. View Article : Google Scholar

21. 

Yurchenco PD, Smirnov S and Mathus T: Analysis of basement membrane self-assembly and cellular interactions with native and recombinant glycoproteins. Methods Cell Biol. 69:111–144. 2002. View Article : Google Scholar : PubMed/NCBI

22. 

Eyre DR: Collagen of articular cartilage. Clin Orthop Relat Res. (427 Suppl): S118–S122. 2004. View Article : Google Scholar

23. 

Andrades JA, Han B, Becerra J, Sorgente N, Hall FL and Nimni ME: A recombinant human TGF-beta1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells. Exp Cell Res. 250:485–498. 1999. View Article : Google Scholar

24. 

Nishi N, Matsushita O, Yuube K, Miyanaka H, Okabe A and Wada F: Collagen-binding growth factors: production and characterization of functional fusion proteins having a collagen-binding domain. Proc Natl Acad Sci USA. 95:7018–7023. 1998. View Article : Google Scholar : PubMed/NCBI

25. 

Ishikawa T, Terai H, Yamamoto T, Harada K and Kitajima T: Delivery of a growth factor fusion protein having collagen-binding activity to wound tissues. Artif Organs. 27:147–154. 2003. View Article : Google Scholar : PubMed/NCBI

26. 

Im GI, Shin YW and Lee KB: Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteoarthritis Cartilage. 13:845–853. 2005. View Article : Google Scholar : PubMed/NCBI

27. 

Im GI, Jung NH and Tae SK: Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors. Tissue Eng. 12:527–536. 2006. View Article : Google Scholar : PubMed/NCBI

28. 

Sun WJ, Sun CK, Lin H, et al: The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials. 30:4649–4656. 2009. View Article : Google Scholar : PubMed/NCBI

29. 

Sun W, Lin H, Chen B, Zhao W, Zhao Y and Dai J: Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta. J Biomed Mater Res A. 83:1054–1061. 2007. View Article : Google Scholar : PubMed/NCBI

30. 

Fischer J, Dickhut A, Rickert M and Richter W: Human articular chondrocytes secrete parathyroid hormone-related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis. Arthritis Rheum. 62:2696–2706. 2010. View Article : Google Scholar

31. 

Schmid TM and Linsenmayer TF: Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues. J Cell Biol. 100:598–605. 1985. View Article : Google Scholar : PubMed/NCBI

32. 

Wang D, Taboas JM and Tuan RS: PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes. Osteoarthritis Cartilage. 19:213–221. 2011. View Article : Google Scholar : PubMed/NCBI

33. 

Kafienah W, Mistry S, Dickinson SC, Sims TJ, Learmonth I and Hollander AP: Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum. 56:177–187. 2007. View Article : Google Scholar : PubMed/NCBI

34. 

Caplan AI: Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng. 11:1198–1211. 2005. View Article : Google Scholar : PubMed/NCBI

35. 

Heldin CH and Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 79:1283–1316. 1999.PubMed/NCBI

36. 

Otto D, Unsicker K and Grothe C: Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia. Neurosci Lett. 83:156–160. 1987. View Article : Google Scholar : PubMed/NCBI

37. 

Ishihara M, Obara K, Ishizuka T, et al: Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization. J Biomed Mater Res A. 64:551–559. 2003. View Article : Google Scholar : PubMed/NCBI

38. 

Cai S, Liu Y, Zheng Shu X and Prestwich GD: Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials. 26:6054–6067. 2005. View Article : Google Scholar : PubMed/NCBI

39. 

Andrades JA, Wu LT, Hall FL, Nimni ME and Becerra J: Engineering, expression, and renaturation of a collagen-targeted human bFGF fusion protein. Growth Factors. 18:261–275. 2001. View Article : Google Scholar : PubMed/NCBI

40. 

Li X, Feng Q, Liu X, Dong W and Cui F: Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model. Biomaterials. 27:1917–1923. 2006. View Article : Google Scholar : PubMed/NCBI

41. 

Park SN, Kim JK and Suh H: Evaluation of antibiotic-loaded collagen-hyaluronic acid matrix as a skin substitute. Biomaterials. 25:3689–3698. 2004. View Article : Google Scholar : PubMed/NCBI

42. 

Rose FR and Oreffo RO: Bone tissue engineering: hope vs. hype. Biochem Biophys Res Commun. 292:1–7. 2002. View Article : Google Scholar : PubMed/NCBI

43. 

Chapekar MS: Tissue engineering: challenges and opportunities. J Biomed Mater Res. 53:617–620. 2000. View Article : Google Scholar : PubMed/NCBI

44. 

Zhao WX, Chen B, Li X, et al: Vascularization and cellularization of collagen scaffolds incorporated with two different collagen-targeting human basic fibroblast growth factors. J Biomed Mater Res A. 82:630–636. 2007. View Article : Google Scholar : PubMed/NCBI

45. 

Lin H, Chen B, Sun W, Zhao W, Zhao Y and Dai Y: The effect of collagen-targeting platelet-derived growth factor on cellularization and vascularization of collagen scaffolds. Biomaterials. 27:5708–5714. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu X, Huang B, Wang J, Li C and Zhou Y: Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs. Int J Mol Med 31: 430-436, 2013.
APA
Wu, X., Huang, B., Wang, J., Li, C., & Zhou, Y. (2013). Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs. International Journal of Molecular Medicine, 31, 430-436. https://doi.org/10.3892/ijmm.2012.1219
MLA
Wu, X., Huang, B., Wang, J., Li, C., Zhou, Y."Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs". International Journal of Molecular Medicine 31.2 (2013): 430-436.
Chicago
Wu, X., Huang, B., Wang, J., Li, C., Zhou, Y."Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs". International Journal of Molecular Medicine 31, no. 2 (2013): 430-436. https://doi.org/10.3892/ijmm.2012.1219
Copy and paste a formatted citation
x
Spandidos Publications style
Wu X, Huang B, Wang J, Li C and Zhou Y: Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs. Int J Mol Med 31: 430-436, 2013.
APA
Wu, X., Huang, B., Wang, J., Li, C., & Zhou, Y. (2013). Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs. International Journal of Molecular Medicine, 31, 430-436. https://doi.org/10.3892/ijmm.2012.1219
MLA
Wu, X., Huang, B., Wang, J., Li, C., Zhou, Y."Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs". International Journal of Molecular Medicine 31.2 (2013): 430-436.
Chicago
Wu, X., Huang, B., Wang, J., Li, C., Zhou, Y."Collagen-targeting parathyroid hormone-related peptide promotes collagen binding and in vitro chondrogenesis in bone marrow-derived MSCs". International Journal of Molecular Medicine 31, no. 2 (2013): 430-436. https://doi.org/10.3892/ijmm.2012.1219
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team