Open Access

The role of peptide YY in gastrointestinal diseases and disorders (Review)

  • Authors:
    • Magdy El-Salhy
    • Tarek Mazzawi
    • Doris Gundersen
    • Jan Gunnar Hatlebakk
    • Trygve Hausken
  • View Affiliations

  • Published online on: December 21, 2012     https://doi.org/10.3892/ijmm.2012.1222
  • Pages: 275-282
  • Copyright: © El-Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Peptide YY (PYY) is affected in several gastrointestinal diseases and disorders. Changes in PYY appear to be an adaptive response to alterations in pathophysiological conditions caused by the disease. This applies to gastrointestinal diseases/disorders such as irritable bowel syndrome, inflammatory bowel disease, celiac disease, systemic sclerosis, and post-intestinal resection. By contrast, the changes in PYY in chronic idiopathic slow transit constipation (CST) seem to be of a primary nature, and may be one etiological factor of the disease. Abnormalities in PYY seem to contribute to the development of symptoms present in irritable bowel syndrome, inflammatory bowel disease, gastroenteropathy in long-standing diabetes and CST. The changes in PYY could, however, be favorable in some gastrointestinal disorders such as celiac disease, systemic sclerosis and post-intestinal resection state. Investigating changes in PYY in gastrointestinal diseases/disorders could be beneficial in clinical practice, where a receptor agonist or an antagonist can be used as a drug, depending on the condition. Similar to other neuroendocrine peptides/amines of the gut, PYY has broad physiological/pharmacological effects: it can bind to and activate several receptors with independent actions. Thus, in order to use PYY as a drug, receptor-specific agonists or antagonists need to be developed.
View Figures
View References

Related Articles

Journal Cover

February 2013
Volume 31 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
El-Salhy M, Mazzawi T, Gundersen D, Hatlebakk JG and Hausken T: The role of peptide YY in gastrointestinal diseases and disorders (Review). Int J Mol Med 31: 275-282, 2013
APA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J.G., & Hausken, T. (2013). The role of peptide YY in gastrointestinal diseases and disorders (Review). International Journal of Molecular Medicine, 31, 275-282. https://doi.org/10.3892/ijmm.2012.1222
MLA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31.2 (2013): 275-282.
Chicago
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31, no. 2 (2013): 275-282. https://doi.org/10.3892/ijmm.2012.1222