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The role of peptide YY in gastrointestinal diseases and disorders (Review)

  • Authors:
    • Magdy El-Salhy
    • Tarek Mazzawi
    • Doris Gundersen
    • Jan Gunnar Hatlebakk
    • Trygve Hausken
  • View Affiliations / Copyright

    Affiliations: Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Stord, Norway, Department of Research, Helse-Fonna, Haugesund, Norway, Section for Gastroenterology, Institute of Medicine, University of Bergen, Bergen, Norway
    Copyright: © El-Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 275-282
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    Published online on: December 21, 2012
       https://doi.org/10.3892/ijmm.2012.1222
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Abstract

Peptide YY (PYY) is affected in several gastrointestinal diseases and disorders. Changes in PYY appear to be an adaptive response to alterations in pathophysiological conditions caused by the disease. This applies to gastrointestinal diseases/disorders such as irritable bowel syndrome, inflammatory bowel disease, celiac disease, systemic sclerosis, and post-intestinal resection. By contrast, the changes in PYY in chronic idiopathic slow transit constipation (CST) seem to be of a primary nature, and may be one etiological factor of the disease. Abnormalities in PYY seem to contribute to the development of symptoms present in irritable bowel syndrome, inflammatory bowel disease, gastroenteropathy in long-standing diabetes and CST. The changes in PYY could, however, be favorable in some gastrointestinal disorders such as celiac disease, systemic sclerosis and post-intestinal resection state. Investigating changes in PYY in gastrointestinal diseases/disorders could be beneficial in clinical practice, where a receptor agonist or an antagonist can be used as a drug, depending on the condition. Similar to other neuroendocrine peptides/amines of the gut, PYY has broad physiological/pharmacological effects: it can bind to and activate several receptors with independent actions. Thus, in order to use PYY as a drug, receptor-specific agonists or antagonists need to be developed.
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Copy and paste a formatted citation
Spandidos Publications style
El-Salhy M, Mazzawi T, Gundersen D, Hatlebakk JG and Hausken T: The role of peptide YY in gastrointestinal diseases and disorders (Review). Int J Mol Med 31: 275-282, 2013.
APA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J.G., & Hausken, T. (2013). The role of peptide YY in gastrointestinal diseases and disorders (Review). International Journal of Molecular Medicine, 31, 275-282. https://doi.org/10.3892/ijmm.2012.1222
MLA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31.2 (2013): 275-282.
Chicago
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31, no. 2 (2013): 275-282. https://doi.org/10.3892/ijmm.2012.1222
Copy and paste a formatted citation
x
Spandidos Publications style
El-Salhy M, Mazzawi T, Gundersen D, Hatlebakk JG and Hausken T: The role of peptide YY in gastrointestinal diseases and disorders (Review). Int J Mol Med 31: 275-282, 2013.
APA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J.G., & Hausken, T. (2013). The role of peptide YY in gastrointestinal diseases and disorders (Review). International Journal of Molecular Medicine, 31, 275-282. https://doi.org/10.3892/ijmm.2012.1222
MLA
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31.2 (2013): 275-282.
Chicago
El-Salhy, M., Mazzawi, T., Gundersen, D., Hatlebakk, J. G., Hausken, T."The role of peptide YY in gastrointestinal diseases and disorders (Review)". International Journal of Molecular Medicine 31, no. 2 (2013): 275-282. https://doi.org/10.3892/ijmm.2012.1222
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