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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2012 Volume 29 Issue 4

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International Journal of Molecular Medicine

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma

  • Authors:
    • Ying Li
    • Ze-song Yang
    • Jun-jun Song
    • Qiong Liu
    • Jian-bin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China, Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
  • Pages: 704-710
    |
    Published online on: January 9, 2012
       https://doi.org/10.3892/ijmm.2012.880
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Abstract

Protocadherin-10 (PCDH10) which is located at 4q28.3, is a member of the cadherin superfamily of cell adhesion molecules. PCDH10 is broadly expressed in normal adult, but nearly undetectable in multiple myeloma (ΜΜ) tissues and cell lines. Its promoter methylation was detected in virtually all the silenced or downregulated cell lines. The silencing of PCDH10 could be reversed by pharmacological demethylation, indicating a methylation-mediated mechanism. In the current study, we investigated 44 patients (23 females, 21 males), 77.27% (34/44) of whom presented high methylation of PCDH10. We found no associations between promoter hypermethylation and gender or age at the time of initial diagnosis. We also examined the role of PCDH10 as a mediator of MM cell proliferation, cell cycle progression, and its involvement in angiogenesis. Our results demonstrate that the PCDH10 gene is a target for epigenetic silencing in MM and provide a link between the dysregulation of angiogenesis and DNA methylation.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Yang Z, Song J, Liu Q and Chen J: Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. Int J Mol Med 29: 704-710, 2012.
APA
Li, Y., Yang, Z., Song, J., Liu, Q., & Chen, J. (2012). Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. International Journal of Molecular Medicine, 29, 704-710. https://doi.org/10.3892/ijmm.2012.880
MLA
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29.4 (2012): 704-710.
Chicago
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29, no. 4 (2012): 704-710. https://doi.org/10.3892/ijmm.2012.880
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Yang Z, Song J, Liu Q and Chen J: Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. Int J Mol Med 29: 704-710, 2012.
APA
Li, Y., Yang, Z., Song, J., Liu, Q., & Chen, J. (2012). Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma. International Journal of Molecular Medicine, 29, 704-710. https://doi.org/10.3892/ijmm.2012.880
MLA
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29.4 (2012): 704-710.
Chicago
Li, Y., Yang, Z., Song, J., Liu, Q., Chen, J."Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma". International Journal of Molecular Medicine 29, no. 4 (2012): 704-710. https://doi.org/10.3892/ijmm.2012.880
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