Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
April 2012 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2012 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism

  • Authors:
    • Aftab Ali Shah
    • Petra Leidinger
    • Andreas Keller
    • Anke Wendschlag
    • Eckart Meese
    • Nikolaus Blin
  • View Affiliations / Copyright

    Affiliations: Division of Molecular Genetics, Institute of Human Genetics, University of Tübingen, Wilhelmstr. 27, D-72074 Tübingen, Germany
  • Pages: 637-643
    |
    Published online on: January 10, 2012
       https://doi.org/10.3892/ijmm.2012.881
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The trefoil peptide family, consisting in mammals of three members namely TFF1, 2 and 3, plays a cytoprotective role in epithelial cells of various tissues, mainly in the digestive tract. Tff1, Tff2 or Tff3 knock-out mouse models developed various kinds of gastrointestinal impairment. microRNAs are known to be novel gene regulators. We aimed to investigate the physiological role of such miRNAs in Tff2 knock-out mice. Whole miRNome profiling and in silico analysis were performed for Tff2-KO and WT mice. Our latest data explored the role of miRNAs in the regulatory cascades and molecular processes of Tff2-/- mice. As much as 6% of the Tff2-KO mice miRNome was significantly dys-regulated. Further in silico analysis suggests that the respective dys-regulated part of the miRNome is involved in human pathological processes, including pancreatic, colorectal and basal cell cancer. Additionally, the dys-regulated miRNome targets pathways involved in carbohydrate metabolism and adipocytokine signaling. The latter links deficient caloric maintenance in Tff2 and previous observation in Tff3-KO mice with miRNAs. In summary, our proof-of-concept study indicates that miRNAs may play an important role in the regulatory processes of the trefoil peptide family, especially in the regulation of cancer-related cascades.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

W HoffmannW JaglaA WiedeMolecular medicine of TFF-peptides: from gut to brainHistol Histopathol16319334200111193208

2 

J MadsenO NielsenI TornoeL ThimU HolmskovTissue localization of human trefoil factors 1, 2, and 3J Histochem Cytochem55505513200710.1369/jhc.6A7100.200717242463

3 

S KjellevThe trefoil factor family - small peptides with multiple functionalitiesCell Mol Life Sci6613501369200910.1007/s00018-008-8646-519099184

4 

GA CookM FamilariL ThimAS GiraudThe trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune responseFEBS Lett456155159199910.1016/S0014-5793(99)00940-010452549

5 

JJ FarrellD TaupinTJ KohTFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injuryJ Clin Invest109193204200210.1172/JCI021252911805131

6 

JG FoxAB RogersMT WharyAccelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2−/− C57BL6 x Sv129 Helicobacter pylori-infected miceAm J Pathol17115201528200710.2353/ajpath.2007.07024917982128

7 

AM HanbyR PoulsomS SinghG EliaRE JefferyNA WrightSpasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomachGastroenterology1051110111619938405856

8 

A DignassK Lynch-DevaneyH KindonL ThimDK PodolskyTrefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathwayJ Clin Invest94376383199410.1172/JCI1173328040278

9 

K KatoMC ChenM NguyenFS LehmannDK PodolskyAH SollEffects of growth factors and trefoil peptides on migration and replication in primary oxyntic culturesAm J Physiol276G1105G1116199910330000

10 

RJ PlayfordT MarchbankR ChineryHuman spasmolytic polypeptide is a cytoprotective agent that stimulates cell migrationGastroenterology108108116199510.1016/0016-5085(95)90014-47806031

11 

C MathelinC TomasettoMC RioTrefoil factor 1 (pS2/TFF1), a peptide with numerous functionsBull Cancer927737812005(In French)

12 

AM HanbyJA JankowskiG EliaR PoulsomNA WrightExpression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barrett's metaplasia and the native oesophageal epithelium: delineation of epithelial phenotypeJ Pathol173213219199410.1002/path.17117303037931841

13 

T SaitohT MochizukiT SudaElevation of TFF1 gene expression during healing of gastric ulcer at non-ulcerated sites in the stomach: semiquantification using the single tube method of polymerase chain reactionJ Gastroenterol Hepatol15604609200010.1046/j.1440-1746.2000.02209.x

14 

AM HanbyR PoulsomG EliaS SinghJM LongcroftNA WrightThe expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in ‘gastric metaplasia’ of the proximal duodenum: implications for the nature of ‘gastric metaplasia’J Pathol1693553601993

15 

G OhshioH SuwaY KawaguchiDifferential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, ampullary carcinomas, and mucin-producing tumors of the pancreasDig Dis Scie45659664200010.1023/A:1005471005289

16 

B TerrisE BlaveriT Crnogorac-JurcevicCharacterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreasAm J Pathol16017451754200210.1016/S0002-9440(10)61121-212000726

17 

NA WrightR PoulsomGW StampEpidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissuesJ Pathol162279284199010.1002/path.17116204022290113

18 

M Baus-LoncarJ Schmidel-N LalaniTrefoil factor 2 (TFF2) deficiency in murine digestive tract influences the immune systemCell Physiol Biochem163142200510.1159/00008772916121031

19 

DP BartelMicroRNAs: genomics, biogenesis, mechanism, and functionCell116281297200410.1016/S0092-8674(04)00045-514744438

20 

AA ShahP LeidingerA KellerThe intestinal factor Tff3 and a miRNA network regulate murine caloric metabolismRNA Biol87781201110.4161/rna.8.1.1368721289491

21 

SF HauslerA KellerPA ChandranWhole blood-derived miRNA profiles as potential new tools for ovarian cancer screeningBr J Cancer103693700201010.1038/sj.bjc.660583320683447

22 

P RothJ WischhusenC HappoldA specific miRNA signature in the peripheral blood of glioblastoma patientsJ Neurochem118449457201110.1111/j.1471-4159.2011.07307.x21561454

23 

S UematsuK FujimotoThe innate immune system in the intestineMicrobiol Immunol54645657201010.1111/j.1348-0421.2010.00267.x21044138

24 

S Griffiths-JonesmiRBase: the microRNA sequence databaseMethods Mol Biol342129138200616957372

25 

S VorwerkK GanterY ChengJ HoheiselPF StahlerM BeierMicrofluidic-based enzymatic on-chip labeling of miRNAsN Biotechnol25142149200810.1016/j.nbt.2008.08.00518786664

26 

BM BolstadRA IrizarryM AstrandTP SpeedA comparison of normalization methods for high density oligonucleotide array data based on variance and biasBioinformatics19185193200310.1093/bioinformatics/19.2.18512538238

27 

M KanehisaS GotoKEGG: kyoto encyclopedia of genes and genomesNucleic Acids Res282730200010.1093/nar/28.1.2710592173

28 

M KanehisaS GotoM HattoriFrom genomics to chemical genomics: new developments in KEGGNucleic Acids Res34D354D357200610.1093/nar/gkj10216381885

29 

M KanehisaS GotoM FurumichiM TanabeM HirakawaKEGG for representation and analysis of molecular networks involving diseases and drugsNucleic Acids Res38D355D360201010.1093/nar/gkp89619880382

30 

H MashimoDC WuDK PodolskyMC FishmanImpaired defense of intestinal mucosa in mice lacking intestinal trefoil factorScience274262265199610.1126/science.274.5285.2628824194

31 

O LefebvreMP ChenardR MassonGastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil proteinScience274259262199610.1126/science.274.5285.2598824193

32 

MR AlisonR ChineryR PoulsomP AshwoodJM LongcroftNA WrightExperimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomachJ Pathol175405414199510.1002/path.1711750408

33 

P GottS BeckJC MachadoF CarneiroH SchmittN BlinHuman trefoil peptides: genomic structure in 21q22.3 and coordinated expressionEur J HuM Genet430831519969043862

34 

S BeckP SommerN BlinP Gott5′-flanking motifs control cell-specific expression of trefoil factor genes (TFF)Int J Mol Med23533611998

35 

AC BrownWI OlverCJ DonnellySearching QTL by gene expression: analysis of diabesityBMC Genet612200510.1186/1471-2156-6-1215760467

36 

KG KumarBK Smith RichardsTranscriptional profiling of chromosome 17 quantitative trait Loci for carbohydrate and total calorie intake in a mouse congenic strain reveals candidate genes and pathwaysJ Nutrigenet Nutrigenomics1155171200810.1159/000113657

37 

A DaddaouaE Martinez-PlataR Lopez-PosadasActive hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitisJ Nutr13712221228200717449585

38 

J ScholvenD TarasS SharbatiIntestinal expression of TFF and related genes during postnatal development in a piglet probiotic trialCell Physiol Biochem23143156200910.1159/00020410319255509

39 

S SharbatiMR FriedlanderJ SharbatiDeciphering the porcine intestinal microRNA transcriptomeBMC Genomics11275201010.1186/1471-2164-11-27520433717

40 

SK PanguluriS BhatnagarA KumarGenomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in micePloS One5e8760201010.1371/journal.pone.000876020098732

41 

F WuS ZhuY DingWT BeckYY MoMicroRNA-mediated regulation of Ubc9 expression in cancer cellsClin Cancer Res1515501557200910.1158/1078-0432.CCR-08-082019223510

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shah AA, Leidinger P, Keller A, Wendschlag A, Meese E and Blin N: Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. Int J Mol Med 29: 637-643, 2012.
APA
Shah, A.A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., & Blin, N. (2012). Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. International Journal of Molecular Medicine, 29, 637-643. https://doi.org/10.3892/ijmm.2012.881
MLA
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29.4 (2012): 637-643.
Chicago
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29, no. 4 (2012): 637-643. https://doi.org/10.3892/ijmm.2012.881
Copy and paste a formatted citation
x
Spandidos Publications style
Shah AA, Leidinger P, Keller A, Wendschlag A, Meese E and Blin N: Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. Int J Mol Med 29: 637-643, 2012.
APA
Shah, A.A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., & Blin, N. (2012). Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. International Journal of Molecular Medicine, 29, 637-643. https://doi.org/10.3892/ijmm.2012.881
MLA
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29.4 (2012): 637-643.
Chicago
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29, no. 4 (2012): 637-643. https://doi.org/10.3892/ijmm.2012.881
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team