Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated respiratory disease

Lee,Jin  Sol; Bae,Joon  Seol; Kim,Jeong-Hyun; Kim,Jason  Yongha; Park,Tae  Joon; Pasaje,Charisse  Flerida; Park,Byung-Lae; Cheong,Hyun  Sub; Jang,An-Soo; Uh,Soo-Taek; Park,Choon-Sik; Shin,Hyoung  Doo

doi:10.3892/ijmm.2012.898

May 2012 Volume 29 Issue 5

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May 2012 Volume 29 Issue 5

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Article

Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated respiratory disease

Authors:
- Jin Sol Lee
- Joon Seol Bae
- Jeong-Hyun Kim
- Jason Yongha Kim
- Tae Joon Park
- Charisse Flerida Pasaje
- Byung-Lae Park
- Hyun Sub Cheong
- An-Soo Jang
- Soo-Taek Uh
- Choon-Sik Park
- Hyoung Doo Shin
View Affiliations / Copyright

Affiliations: Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea, Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-801, Republic of Korea, Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul Hospital, Seoul 140-743, Republic of Korea, Genome Research Center for Allergy and Respiratory Diseases, Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 420-767, Republic of Korea
Pages: 927-933
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Published online on: January 26, 2012

https://doi.org/10.3892/ijmm.2012.898
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Abstract

Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome that is characterized by nasal polyposis, general symptoms of asthma and sensitive response to non-steroidal anti-inflammatory drugs (NSAIDs). Although the exact function of tripartite motif-containing 26 (TRIM26) still remains unknown, the gene functions in the immune response. Thus, we hypothesized that TRIM26 polymorphisms may affect aspirin-induced bronchospasm and explored whether the gene can be a marker for diagnosis of AERD. To investigate our hypothesis that TRIM26 may serve as a genetic marker for diagnosis of AERD, this study focused on demonstrating the associations between single nucleotide polymorphisms (SNPs) of the TRIM26 gene and AERD. We genotyped 18 polymorphisms of TRIM26 in a total of 189 asthmatics and examined their associations with the risk of AERD. We performed logistic analysis for obtaining P-values and regression analysis for demonstrating an association between the phenotype with FEV1 and the genotype. We observed no associations between polymorphisms in TRIM26 and the risk of AERD in both logistic and regression analyses. Although our results reveal a lack of association, the suggested functional role of TRIM26 makes it a putative candidate gene for AERD. Thus, replications in other populations using larger samples may provide valuable information for AERD etiology.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated respiratory disease

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