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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2012 Volume 29 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article Open Access

Effects of thermal water on skin regeneration

  • Authors:
    • Angela Faga
    • Giovanni Nicoletti
    • Cesarina Gregotti
    • Valentina Finotti
    • Agnese Nitto
    • Luciana Gioglio

  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, University of Pavia - IRCCS Fondazione ‘S. Maugeri’, Pavia, Italy, Department of Cellular and Molecular Pharmacology, University of Pavia, Pavia, Italy, Department of Human Anatomy, University of Pavia, Pavia, Italy
  • Pages: 732-740
    |
    Published online on: February 15, 2012
       https://doi.org/10.3892/ijmm.2012.917
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Abstract

An experimental study was carried out in an animal (New Zealand white rabbit) wound model to evaluate any effects of a hypotonic, bicarbonate-calcium-magnesium mineral water (Comano thermal water) on skin regeneration, comparing the healing rate of split-thickness skin graft donor sites treated with the thermal water wet dressing versus a standard petrolatum gauze dressing versus a saline solution wet dressing. The study was performed in two steps; an overall of 22 animals were enrolled in the study. The wound healing progress was evaluated both by the surgeons and by the histologists. Sixty-four punch biopsies were examined in all. The histological samples were examined after staining with haematoxylin and eosin, Masson's and orcein staining and under a transmission electron microscope. The data were statistically analysed. The Comano thermal water proved to improve skin regeneration, not only by increasing keratinocyte proliferation and migration but also favourably modulating the regenerated collagen and elastic fibres in the dermis. We propose that the results of the topical treatment with the thermal water could be due to the favourable combination of a local wet environment with an anti-inflammatory action and that the regenerative properties of Comano thermal water observed in rabbits could also be applied for human use.

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Copy and paste a formatted citation
Spandidos Publications style
Faga A, Nicoletti G, Gregotti C, Finotti V, Nitto A and Gioglio L: Effects of thermal water on skin regeneration. Int J Mol Med 29: 732-740, 2012.
APA
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., & Gioglio, L. (2012). Effects of thermal water on skin regeneration. International Journal of Molecular Medicine, 29, 732-740. https://doi.org/10.3892/ijmm.2012.917
MLA
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., Gioglio, L."Effects of thermal water on skin regeneration". International Journal of Molecular Medicine 29.5 (2012): 732-740.
Chicago
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., Gioglio, L."Effects of thermal water on skin regeneration". International Journal of Molecular Medicine 29, no. 5 (2012): 732-740. https://doi.org/10.3892/ijmm.2012.917
Copy and paste a formatted citation
x
Spandidos Publications style
Faga A, Nicoletti G, Gregotti C, Finotti V, Nitto A and Gioglio L: Effects of thermal water on skin regeneration. Int J Mol Med 29: 732-740, 2012.
APA
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., & Gioglio, L. (2012). Effects of thermal water on skin regeneration. International Journal of Molecular Medicine, 29, 732-740. https://doi.org/10.3892/ijmm.2012.917
MLA
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., Gioglio, L."Effects of thermal water on skin regeneration". International Journal of Molecular Medicine 29.5 (2012): 732-740.
Chicago
Faga, A., Nicoletti, G., Gregotti, C., Finotti, V., Nitto, A., Gioglio, L."Effects of thermal water on skin regeneration". International Journal of Molecular Medicine 29, no. 5 (2012): 732-740. https://doi.org/10.3892/ijmm.2012.917
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