Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients

Fibach,Eitan; Prus,Eugenia; Bianchi,Nicoletta; Zuccato,Cristina; Breveglieri,Giulia; Salvatori,Francesca; Finotti,Alessia; Lipucci di Paola,Michele; Brognara,Eleonora; Lampronti,Ilaria; Borgatti,Monica; Gambari,Roberto

doi:10.3892/ijmm.2012.928

June 2012 Volume 29 Issue 6

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June 2012 Volume 29 Issue 6

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Article

Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients

Authors:
- Eitan Fibach
- Eugenia Prus
- Nicoletta Bianchi
- Cristina Zuccato
- Giulia Breveglieri
- Francesca Salvatori
- Alessia Finotti
- Michele Lipucci di Paola
- Eleonora Brognara
- Ilaria Lampronti
- Monica Borgatti
- Roberto Gambari
View Affiliations / Copyright

Affiliations: Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassaemia, Biotechnology Centre, Ferrara, Italy, Department of Biology of Agricultural Plants, University of Pisa, Pisa, Italy
Pages: 974-982
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Published online on: February 28, 2012

https://doi.org/10.3892/ijmm.2012.928
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Abstract

Thalassemia and sickle-cell anemia (SCA) present a major public health problem in countries where the number of carriers and affected individuals is high. As a result of the abnormalities in hemoglobin production, cells of thalassemia and SCA patients exhibit oxidative stress, which ultimately is responsible for the chronic anemia observed. Therefore, identification of compounds exhibiting both antioxidant and hemoglobin-inducing activities is highly needed. Our results demonstrate resveratrol to be such a compound. This was shown both in the human K562 cell line, as well as in erythroid precursors derived from normal donors and β-thalassemia patients. Resveratrol was shown to exhibit antioxidant activity and to stimulate the expression of the γ-globin genes and the accumulation of fetal hemoglobin (HbF). To the best of our knowledge, this is the first report pointing to such a double effect of resveratrol. Since this natural product is already marketed as an antioxidant, future investigations should concentrate on demonstrating its potential to augment HbF production in experimental animal models (e.g., thalassemia and SCA mice) as well as in patients. We believe that the potential of clinical use of resveratrol as an antioxidant and HbF stimulator may offer a simple and inexpensive treatment to patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients

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