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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2012 Volume 29 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription

  • Authors:
    • Birger Dieriks
    • Patrick Van Oostveldt

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biotechnology, Ghent University, Ghent, Belgium
  • Pages: 1031-1038
    |
    Published online on: March 13, 2012
       https://doi.org/10.3892/ijmm.2012.937
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Abstract

Cyclophilin B (CypB) is an ubiquitously expressed protein, which performs several intra- and extracellular functions. Despite its abundant use as a household protein, little is known about its exact cellular localization and dynamics. In the present study we show that endogenous CypB localizes in one of two distinct compartments, either within the endoplasmic reticulum (ER) or inside the nucleus, accumulating in the fibrillar centers of the nucleoli. By means of a genetic deletion screen, we identified a minimal nucleolar localization signal for efficient relocation to the nucleoli. Within the fibrillar centers, CypB colocalized with RNA polymerase, upstream binding factor-1 (UBF), fibrillarin and dyskerin (DCK1). Even after chemical disruption of the nucleoli, a strong interaction with these proteins remained. Using live cell imaging, we showed a persistent colocalization of CypB with proteins involved in the ribosome biogenesis during the transcriptionally more active phases of the cell cycle. Supported by in silico data, our observations suggest that CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription.

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Copy and paste a formatted citation
Spandidos Publications style
Dieriks B and Van Oostveldt P: Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. Int J Mol Med 29: 1031-1038, 2012.
APA
Dieriks, B., & Van Oostveldt, P. (2012). Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. International Journal of Molecular Medicine, 29, 1031-1038. https://doi.org/10.3892/ijmm.2012.937
MLA
Dieriks, B., Van Oostveldt, P."Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription". International Journal of Molecular Medicine 29.6 (2012): 1031-1038.
Chicago
Dieriks, B., Van Oostveldt, P."Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription". International Journal of Molecular Medicine 29, no. 6 (2012): 1031-1038. https://doi.org/10.3892/ijmm.2012.937
Copy and paste a formatted citation
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Spandidos Publications style
Dieriks B and Van Oostveldt P: Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. Int J Mol Med 29: 1031-1038, 2012.
APA
Dieriks, B., & Van Oostveldt, P. (2012). Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. International Journal of Molecular Medicine, 29, 1031-1038. https://doi.org/10.3892/ijmm.2012.937
MLA
Dieriks, B., Van Oostveldt, P."Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription". International Journal of Molecular Medicine 29.6 (2012): 1031-1038.
Chicago
Dieriks, B., Van Oostveldt, P."Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription". International Journal of Molecular Medicine 29, no. 6 (2012): 1031-1038. https://doi.org/10.3892/ijmm.2012.937
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