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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2012 Volume 30 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 30 Issue 1

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Article

Interleukin-12 inhibits cell invasion in choriocarcinoma

  • Authors:
    • Zhuo Zhang
    • Qian Xu
    • Changhua Shi
    • Yuhong Li

  • View Affiliations / Copyright

    Affiliations: Department of Basic Medicine, Chengde Medical College, Chengde 067000, Hebei, P.R. China
  • Pages: 57-62
    |
    Published online on: April 3, 2012
       https://doi.org/10.3892/ijmm.2012.960
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Abstract

Gestational trophoblastic disease (GTD) is a unique disease that arises from allografting of the conceptus, and has a characteristic morphology and biological behavior. It encompasses a spectrum of interrelated diseases, including hydatidiform mole, invasive mole, choriocarcinoma and placental-site trophoblastic tumor, but its pathogenesis remains unrevealed. Particularly, choriocarcinoma is a highly malignant tumor with poor prognosis. In this study, we cultured the human choriocarcinoma cell line JEG-3 in vitro. After treating the cells with different doses of interleukin (IL)-12, the cell invasion was observed. We also detected the expression of matrix metalloproteinases (MMP)-9 and tissue inhibitors of metalloproteinases (TIMP)-1 and the cell cycle of JEG-3 cells. Our data indicated that IL-12 inhibits cell invasion in a dose- and time-dependent manner through regulating the expression of MMP-9 and TIMP-1. In addition, treatment with IL-12 redistributes the phases of the cell cycle in JEG-3 cells. These findings suggest an antitumor role of IL-12 in choriocarcinoma, with far reaching possibilities for understanding the mechanisms of IL-12.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Xu Q, Shi C and Li Y: Interleukin-12 inhibits cell invasion in choriocarcinoma. Int J Mol Med 30: 57-62, 2012.
APA
Zhang, Z., Xu, Q., Shi, C., & Li, Y. (2012). Interleukin-12 inhibits cell invasion in choriocarcinoma. International Journal of Molecular Medicine, 30, 57-62. https://doi.org/10.3892/ijmm.2012.960
MLA
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30.1 (2012): 57-62.
Chicago
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30, no. 1 (2012): 57-62. https://doi.org/10.3892/ijmm.2012.960
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Xu Q, Shi C and Li Y: Interleukin-12 inhibits cell invasion in choriocarcinoma. Int J Mol Med 30: 57-62, 2012.
APA
Zhang, Z., Xu, Q., Shi, C., & Li, Y. (2012). Interleukin-12 inhibits cell invasion in choriocarcinoma. International Journal of Molecular Medicine, 30, 57-62. https://doi.org/10.3892/ijmm.2012.960
MLA
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30.1 (2012): 57-62.
Chicago
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30, no. 1 (2012): 57-62. https://doi.org/10.3892/ijmm.2012.960
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