Interleukin-12 inhibits cell invasion in choriocarcinoma

  • Authors:
    • Zhuo Zhang
    • Qian Xu
    • Changhua Shi
    • Yuhong Li
  • View Affiliations

  • Published online on: April 3, 2012     https://doi.org/10.3892/ijmm.2012.960
  • Pages: 57-62
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Abstract

Gestational trophoblastic disease (GTD) is a unique disease that arises from allografting of the conceptus, and has a characteristic morphology and biological behavior. It encompasses a spectrum of interrelated diseases, including hydatidiform mole, invasive mole, choriocarcinoma and placental-site trophoblastic tumor, but its pathogenesis remains unrevealed. Particularly, choriocarcinoma is a highly malignant tumor with poor prognosis. In this study, we cultured the human choriocarcinoma cell line JEG-3 in vitro. After treating the cells with different doses of interleukin (IL)-12, the cell invasion was observed. We also detected the expression of matrix metalloproteinases (MMP)-9 and tissue inhibitors of metalloproteinases (TIMP)-1 and the cell cycle of JEG-3 cells. Our data indicated that IL-12 inhibits cell invasion in a dose- and time-dependent manner through regulating the expression of MMP-9 and TIMP-1. In addition, treatment with IL-12 redistributes the phases of the cell cycle in JEG-3 cells. These findings suggest an antitumor role of IL-12 in choriocarcinoma, with far reaching possibilities for understanding the mechanisms of IL-12.

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July 2012
Volume 30 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang Z, Xu Q, Shi C and Li Y: Interleukin-12 inhibits cell invasion in choriocarcinoma. Int J Mol Med 30: 57-62, 2012
APA
Zhang, Z., Xu, Q., Shi, C., & Li, Y. (2012). Interleukin-12 inhibits cell invasion in choriocarcinoma. International Journal of Molecular Medicine, 30, 57-62. https://doi.org/10.3892/ijmm.2012.960
MLA
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30.1 (2012): 57-62.
Chicago
Zhang, Z., Xu, Q., Shi, C., Li, Y."Interleukin-12 inhibits cell invasion in choriocarcinoma". International Journal of Molecular Medicine 30, no. 1 (2012): 57-62. https://doi.org/10.3892/ijmm.2012.960