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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2012 Volume 30 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Virus capture using anionic polymer-coated magnetic beads (Review)

Akikazu Sakudo, Takashi Onodera
Pages: 3-7
Published online on: 10 April 2012

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Article Open Access

Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation

Jung-Il Chae, Jin Hyoung Cho, Dong Joon Kim, Kyung-Ae Lee, Moon-Kyun Cho, Hae-Seon Nam, Kee-Min Woo, Sang-Han Lee, Jung-Hyun Shim
Pages: 8-14
Published online on: 10 April 2012

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Article Open Access

Nitric oxide prevents phosphorylation of neuronal nitric oxide synthase at Serine1412 by inhibiting the Akt/PKB and CaM-K II signaling pathways

Tao Song, Naoya Hatano, Katsuyoshi Sugimoto, Mariko Horii, Fuminori Yamaguchi, Masaaki Tokuda, Yoshiaki Miyamoto, Toshie Kambe, Yasuo Watanabe
Pages: 15-20
Published online on: 20 April 2012

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Article Open Access

The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1

Kyung-Ae Lee, Yong-Jin Lee, Jung Ok Ban, Yoon-Jin Lee, Sang-Han Lee, Moon-Kyun Cho, Hae-Seon Nam, Jin Tae Hong, Jung-Hyun Shim
Pages: 21-27
Published online on: 23 April 2012

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Article Open Access

Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats

Norihisa Kimura, Kenichi Hakamada, Shojiro-Kazunori Ikenaga, Yutaka Umehara, Yoshikazu Toyoki , Mutsuo Sasaki
Pages: 28-34
Published online on: 20 April 2012

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Article

Differential effects of TGF-β1 and FGF-2 on SDF-1α expression in human periodontal ligament cells derived from deciduous teeth in vitro

Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshitaka Yoshimura, Yuri  Fujihara, Takamasa Kitamura, Mitsuro Tanaka, Akira Ishisaki, Masato Mitome
Pages: 35-40
Published online on: 02 April 2012

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Article

Integrated effect of EGFR and PAR-1 signaling crosstalk on airway hyperresponsiveness

Takahiro Yoshikawa, Hiroshi Kanazawa
Pages: 41-48
Published online on: 23 April 2012

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Article

Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease

Rita De Vito, Anna Alisi, Andrea Masotti, Sara Ceccarelli, Nadia Panera, Arianna Citti, Michele Salata, Luca Valenti, Ariel E. Feldstein, Valerio Nobili
Pages: 49-56
Published online on: 10 April 2012

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Article

Interleukin-12 inhibits cell invasion in choriocarcinoma

Zhuo Zhang, Qian Xu, Changhua Shi, Yuhong Li
Pages: 57-62
Published online on: 03 April 2012

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Article

Silencing of c-kit with small interference RNA attenuates inflammation in a murine model of allergic asthma

Wei Wu, Tao Wang, Jia-Jia Dong, Zeng-Lin Liao, Fu-Qiang Wen
Pages: 63-68
Published online on: 10 April 2012

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Article

EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity

Yoo-Hyun Lee, Jieun Kwak, Hyo-Kyoung Choi, Kyung-Chul Choi, Sunoh Kim, Jeongmin Lee, Woojin Jun, Hyun-Jin Park, Ho-Geun Yoon
Pages: 69-74
Published online on: 10 April 2012

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Article

Molecular characterization of three major outer membrane proteins, TSA56, TSA47 and TSA22, in Orientia tsutsugamushi

Ching-Chih Lin, Chia-Hua Chou, Tung-Cheng Lin, Ming-Chang Yang, Chung-Lung Cho, Chung-Hsing Chang, Hsin-Su Yu, Chung-Hsu Lai, Li-Kuang Chen, Yi-Ren Hong
Pages: 75-84
Published online on: 10 April 2012

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Article

Autologous transplantation of adipose-derived mesenchymal stem cells ameliorates streptozotocin-induced diabetic nephropathy in rats by inhibiting oxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway

Yan Fang, Xiaohong Tian, Shuling Bai, Jun Fan, Weijian Hou, Hao Tong, Dehua Li
Pages: 85-92
Published online on: 23 April 2012

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Article

Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

Ling Liu, Zhi-Xiu Lin, Po Sing Leung, Li-Hua Chen, Ming Zhao, Juan Liang
Pages: 93-99
Published online on: 23 April 2012

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Article

Apple polysaccharides induce apoptosis in colorectal cancer cells

Dian Zhang, Yang Sun, Zhenggang Yue, Qian Li, Jin Meng, Junajuan Liu, Xiang Hekong, Fengliang Jiang, Man Mi, Li Liu, Qibing Mei
Pages: 100-106
Published online on: 26 March 2012

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Article

Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice

Jun Kato, Masahiko Koda, Manabu Kishina, Shiho Tokunaga, Tomomitsu Matono, Takaaki Sugihara, Masaru Ueki, Yoshikazu Murawaki
Pages: 107-113
Published online on: 02 April 2012

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Article

X-irradiation induces cell death in fetal fibroblasts

Michaël Beck, Marjan Moreels, Paul Jacquet, Patrick Van Oostveldt, Winnok H. De Vos, Sarah Baatout
Pages: 114-118
Published online on: 10 April 2012

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Article

Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model

Pin Chen, Qiyang Shi, Xiangjin Xu, Yanqiao Wang, Wenyu Chen, Huiling Wang
Pages: 119-125
Published online on: 02 April 2012

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Article

Antitumor effect of FP3 in combination with cetuximab on patient-derived tumor tissue xenograft models of primary colon carcinoma and related lymphatic and hepatic metastases

Xiaofang Dong, Ketao Jin, Xiaoyan Hu, Fangmin Du, Huanrong Lan, Na Han, Zhaosheng Ma, Bojian Xie, Binbin Cui, Lisong Teng, Feilin Cao
Pages: 126-132
Published online on: 10 April 2012

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Article

Screening for differential methylation status in human placenta in preeclampsia using a CpG island plus promoter microarray

Rui-Zhe Jia, Xiang Zhang, Ping Hu, Xiao-Mei Liu, Xiang-Dong Hua, Xin Wang, Hong-Juan Ding
Pages: 133-141
Published online on: 25 April 2012

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Article

The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma

Michał Panek, Tadeusz Pietras, Adam Antczak, Artur Fabijan, Marcelina Przemęcka, Paweł Górski, Piotr Kuna, Janusz Szemraj
Pages: 142-150
Published online on: 02 April 2012

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Article

Inhibition of human topoisomerase I and activation of caspase-3 by aza-angucyclinones and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones

Francisco A. Monsalve, Jaime A. Valderrama, David Vásquez, Andrea Ibacache, Jaime A. Rodríguez, Daniel R. González, Elba Leiva, Enrique González
Pages: 151-156
Published online on: 03 April 2012

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Article

Chitosan oligosaccharide inhibits LPS-induced apoptosis of vascular endothelial cells through the BKCa channel and the p38 signaling pathway

Jiajia Li, Junlin He, Chao Yu
Pages: 157-164
Published online on: 02 April 2012

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Article

Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo

Natsumi Iitsuka, Mamiko Hie, Atsuko Nakanishi, Ikuyo Tsukamoto
Pages: 165-172
Published online on: 20 April 2012

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Article

Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis

Weiguo Sui, Huan Li, Minglin Ou, Dong'e Tang, Yong Dai
Pages: 173-178
Published online on: 20 April 2012

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Article

Epigenetic inactivation of PLCD1 in chronic myeloid leukemia

Jun-Jun Song, Qiong Liu, Ying Li, Ze-Song Yang, Li Yang, Ting-Xiu Xiang, Guo-Sheng Ren, Jian-Bin Chen
Pages: 179-184
Published online on: 20 April 2012

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Article

Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome

Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
Pages: 185-192
Published online on: 20 April 2012

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Article

The chalcone derivative Chana 1 protects against amyloid β peptide-induced oxidative stress and cognitive impairment

Jieun Kwak, Mi-Jeong Kim, Kyung-Chul Choi, Hyo-Kyung Choi, Woojin Jun, Hyun-Jin Park, Yoo-Hyun Lee, Ho-Geun Yoon
Pages: 193-198
Published online on: 25 April 2012

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Article

Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock

Wayne W. Chaung, Rongqian Wu, Youxin Ji, Weifeng Dong, Ping Wang
Pages: 199-203
Published online on: 02 April 2012

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Article

Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases

Hye Young Park, Gi-Young Kim, Yung Hyun Choi
Pages: 204-210
Published online on: 23 April 2012

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Article

The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro

Yong Liu, Jingjing Jiang, He Xiao, Xiaokui Wang, Yan Li, Yubo Gong, Yifei Huang
Pages: 211-219
Published online on: 20 April 2012

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of adipocytes and their derived extracellular vesicles in the progression, diagnosis and treatment of liver diseases (Review)

Kangrong Li, Muhammad Zubair, Yongmin Yan, Jiahao Xu
Article Number: 293
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma

In Sik Shin, Mee Young Lee, Woo Young Jeon, Na Ra Shin, Chang Seob Seo, Hyekyung Ha
Article Number: 292
Published online on: 20 August 2026

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Review Open Access

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review)

Denita Charoenthanakitkul, Chaiyaboot Ariyachet
Article Number: 291
Published online on: 20 August 2026

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Review Open Access

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review)

Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang, Feihong Shu, Ya Deng, Ting Zhang, Jingyu Xu, Rui Xie
Article Number: 290
Published online on: 18 August 2026

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Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review)

Yuena Qiu, Xiaojing Guo, Jie An
Article Number: 289
Published online on: 18 August 2026

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Review Open Access

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

Shengyao Peng, Zhuo Yao, Junzhe Guo, Chi Zhang, Keda Yang, Lin Tao
Article Number: 288
Published online on: 17 August 2026

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Retraction Open Access

[Retracted] Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Article Number: 287
Published online on: 17 August 2026

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Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Article Open Access

Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Review Open Access

Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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Article Open Access

G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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Review Open Access

XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Review Open Access

Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Review Open Access

Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Review Open Access

Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Research progress on BTG2 in non‑tumor diseases (Review)

Shuling Li, Xiaomei Liu, Zheng Zhang, Ling Yang, Yuxuan Li, Qiongdan Hu
Article Number: 299
Published online on: 28 August 2026

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Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Xincheng Feng, Jue Zhang, Qinghong Ma, Chao Sun
Article Number: 298
Published online on: 27 August 2026

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Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Review Open Access

Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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