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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2012 Volume 30 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Epigenetic inactivation of PLCD1 in chronic myeloid leukemia

  • Authors:
    • Jun-Jun Song
    • Qiong Liu
    • Ying Li
    • Ze-Song Yang
    • Li Yang
    • Ting-Xiu Xiang
    • Guo-Sheng Ren
    • Jian-Bin Chen

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China, Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China, Chongqing Medical University, Chongqing, P.R. China, Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
  • Pages: 179-184
    |
    Published online on: April 20, 2012
       https://doi.org/10.3892/ijmm.2012.970
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Abstract

Phospholipase C δ1 (PLCD1), is located at the important tumor suppressor locus 3p22. It encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. PLCD1 has been studied in some human solid tumors relating to the CpG island methylation of the gene promoter as a functional tumor suppressor. However, no such information is available in chronic myeloid leukemia (CML). In this study, we investigated PLCD1 expression in the CML K562 cell line (0/1) and 15% (2/13) of bone marrow mononuclear cells with CML by using semi-quantitative PCR. The CpG island (CGI) methylation status of the PLCD1 promoter was detected in K562 (0/1) and 56% (23/41) of CML patients by methylation-specific PCR (MSP), but not in the normal adult bone marrow mononuclear cells. Furthermore, the DNA demethylation agent 5'-aza-2'deoxycytidine restored the expression of PLCD1 in K562 cells. Functional studies showed that ectopic expression of PLCD1 in K562 cells was able to dramatically inhibit their colony formation and induce cell cycle G1 arrest, suggesting that PLCD1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of CML.

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Copy and paste a formatted citation
Spandidos Publications style
Song J, Liu Q, Li Y, Yang Z, Yang L, Xiang T, Ren G and Chen J: Epigenetic inactivation of PLCD1 in chronic myeloid leukemia. Int J Mol Med 30: 179-184, 2012.
APA
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T. ... Chen, J. (2012). Epigenetic inactivation of PLCD1 in chronic myeloid leukemia. International Journal of Molecular Medicine, 30, 179-184. https://doi.org/10.3892/ijmm.2012.970
MLA
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T., Ren, G., Chen, J."Epigenetic inactivation of PLCD1 in chronic myeloid leukemia". International Journal of Molecular Medicine 30.1 (2012): 179-184.
Chicago
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T., Ren, G., Chen, J."Epigenetic inactivation of PLCD1 in chronic myeloid leukemia". International Journal of Molecular Medicine 30, no. 1 (2012): 179-184. https://doi.org/10.3892/ijmm.2012.970
Copy and paste a formatted citation
x
Spandidos Publications style
Song J, Liu Q, Li Y, Yang Z, Yang L, Xiang T, Ren G and Chen J: Epigenetic inactivation of PLCD1 in chronic myeloid leukemia. Int J Mol Med 30: 179-184, 2012.
APA
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T. ... Chen, J. (2012). Epigenetic inactivation of PLCD1 in chronic myeloid leukemia. International Journal of Molecular Medicine, 30, 179-184. https://doi.org/10.3892/ijmm.2012.970
MLA
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T., Ren, G., Chen, J."Epigenetic inactivation of PLCD1 in chronic myeloid leukemia". International Journal of Molecular Medicine 30.1 (2012): 179-184.
Chicago
Song, J., Liu, Q., Li, Y., Yang, Z., Yang, L., Xiang, T., Ren, G., Chen, J."Epigenetic inactivation of PLCD1 in chronic myeloid leukemia". International Journal of Molecular Medicine 30, no. 1 (2012): 179-184. https://doi.org/10.3892/ijmm.2012.970
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