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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2012 Volume 30 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 30 Issue 1

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Article

Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis

  • Authors:
    • Weiguo Sui
    • Huan Li
    • Minglin Ou
    • Dong'e Tang
    • Yong Dai

  • View Affiliations / Copyright

    Affiliations: Nephrology Department, 181 Hospital, Guangxi Key Laboratory for Metabolic Diseases Research, Guilin 541002, Guangxi, P.R. China, Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen 518020, Guangdong, P.R. China
  • Pages: 173-178
    |
    Published online on: April 20, 2012
       https://doi.org/10.3892/ijmm.2012.975
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Abstract

Mesangial proliferative glomerulonephritis (MsPGN) is one of the most common immune-mediated renal diseases. The mesangium is expanded and hypercellular, immuno­globulin deposits can be found in the mesangium, but the mechanism underlying its cause remains largely unclear. There is a large amount of evidence suggesting that long ﹥200 nucleotide) non-coding RNAs (lncRNA) have important regulatory functions in the epigenetic control of gene expression. Multiple lines of evidence increasingly link mutations and dysregulations of lncRNAs to a diverse number of human diseases. Through microarray expression analysis, tests show that thousands of lncRNAs and protein-coding genes are significantly differentially expressed in IgA-negative MsPGN. Some lncRNAs and their neighboring protein-coding genes are closely related and are cooperatively expressed. This may be part of a potential regulatory mechanism. The malfunction of regulation in the network of lncRNAs may be a possible mechanism for the development of IgA-negative MsPGN. Our observations suggest that some lncRNAs are closely related to IgA-negative MsPGN and may be playing an important role in this disease.

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Copy and paste a formatted citation
Spandidos Publications style
Sui W, Li H, Ou M, Tang D and Dai Y: Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. Int J Mol Med 30: 173-178, 2012.
APA
Sui, W., Li, H., Ou, M., Tang, D., & Dai, Y. (2012). Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. International Journal of Molecular Medicine, 30, 173-178. https://doi.org/10.3892/ijmm.2012.975
MLA
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30.1 (2012): 173-178.
Chicago
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30, no. 1 (2012): 173-178. https://doi.org/10.3892/ijmm.2012.975
Copy and paste a formatted citation
x
Spandidos Publications style
Sui W, Li H, Ou M, Tang D and Dai Y: Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. Int J Mol Med 30: 173-178, 2012.
APA
Sui, W., Li, H., Ou, M., Tang, D., & Dai, Y. (2012). Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. International Journal of Molecular Medicine, 30, 173-178. https://doi.org/10.3892/ijmm.2012.975
MLA
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30.1 (2012): 173-178.
Chicago
Sui, W., Li, H., Ou, M., Tang, D., Dai, Y."Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis". International Journal of Molecular Medicine 30, no. 1 (2012): 173-178. https://doi.org/10.3892/ijmm.2012.975
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