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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2012 Volume 30 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Review

Evolving applications of microarray technology in postnatal diagnosis (Review)

  • Authors:
    • Ji Un Kang
    • Sun Hoe Koo
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Laboratory Science, Korea Nazarene University, Cheonan, Republic of Korea, Department of Laboratory Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea
  • Pages: 223-228
    |
    Published online on: May 9, 2012
       https://doi.org/10.3892/ijmm.2012.988
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Abstract

Microarray-based cytogenetics is revealing the tremendous fluidity and complexity of the human genome, and is starting to illustrate the implications of genomic variability with respect to human health and disease. In the last few years, the robustness of array-based technologies has provided accurate diagnosis and appropriate clinical management in a timely and efficient manner for identifying genomic defects of congenital and developmental abnormalities including developmental delay (DD), intellectual disability (ID), autism spectrum disorders (ASD) and/or multiple congenital anomalies (MCA). The implementation of this technology in these categories of disorders has been thoroughly evaluated and is now recommended as a first-line diagnostic approach for clinically suspected genetic disorders. However, clinical application of array-CGH in postnatal evaluation raises the debate of whether array-CGH will replace traditional cytogenetics in the near future and whether there is still a role for karyotyping and FISH. In this article, we therefore review the current status of array-based technology use for postnatal diagnosis and predict that it will replace standard cytogenetics as a first-line test for clinical evaluation in these population groups.
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Copy and paste a formatted citation
Spandidos Publications style
Kang JU and Koo SH: Evolving applications of microarray technology in postnatal diagnosis (Review). Int J Mol Med 30: 223-228, 2012.
APA
Kang, J.U., & Koo, S.H. (2012). Evolving applications of microarray technology in postnatal diagnosis (Review). International Journal of Molecular Medicine, 30, 223-228. https://doi.org/10.3892/ijmm.2012.988
MLA
Kang, J. U., Koo, S. H."Evolving applications of microarray technology in postnatal diagnosis (Review)". International Journal of Molecular Medicine 30.2 (2012): 223-228.
Chicago
Kang, J. U., Koo, S. H."Evolving applications of microarray technology in postnatal diagnosis (Review)". International Journal of Molecular Medicine 30, no. 2 (2012): 223-228. https://doi.org/10.3892/ijmm.2012.988
Copy and paste a formatted citation
x
Spandidos Publications style
Kang JU and Koo SH: Evolving applications of microarray technology in postnatal diagnosis (Review). Int J Mol Med 30: 223-228, 2012.
APA
Kang, J.U., & Koo, S.H. (2012). Evolving applications of microarray technology in postnatal diagnosis (Review). International Journal of Molecular Medicine, 30, 223-228. https://doi.org/10.3892/ijmm.2012.988
MLA
Kang, J. U., Koo, S. H."Evolving applications of microarray technology in postnatal diagnosis (Review)". International Journal of Molecular Medicine 30.2 (2012): 223-228.
Chicago
Kang, J. U., Koo, S. H."Evolving applications of microarray technology in postnatal diagnosis (Review)". International Journal of Molecular Medicine 30, no. 2 (2012): 223-228. https://doi.org/10.3892/ijmm.2012.988
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