Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March 2013 Volume 31 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2013 Volume 31 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines

  • Authors:
    • Nina Trošt
    • Neli Hevir
    • Tea Lanišnik Rižner
    • Nataša Debeljak
  • View Affiliations / Copyright

    Affiliations: Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  • Pages: 717-725
    |
    Published online on: January 8, 2013
       https://doi.org/10.3892/ijmm.2013.1231
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Erythropoietin (EPO) receptor (EPOR) expression in breast cancer has been shown to correlate with the expression of estrogen receptor (ESR) and progesterone receptor (PGR) and to be associated with the response to tamoxifen in ESR+/PGR+ tumors but not in ESR- tumors. In addition, the correlation between EPOR and G protein-coupled estrogen receptor 1 [GPER; also known as G protein-coupled receptor 30 (GPR30)] has been reported, suggesting the prognostic potential of EPOR expression. Moreover, the involvement of colony stimulating factor 2 receptor, β, low‑affinity (CSF2RB) and ephrin type-B receptor 4 (EPHB4) as EPOR potential receptor partners in cancer has been indicated. This study analyzed the correlation between the expression of genes for EPO, EPOR, CSF2RB, EPHB4, ESR, PGR and GPER in the MCF-7, MDA-MB-361, T-47D, MDA-MB-231, Hs578Bst, SKBR3, MCF-10A and Hs578T cell lines. The cell lines were also treated with recombinant human EPO (rHuEPO) in order to determine its ability to activate the Jak/STAT5, MAPK and PI3K signaling pathways and modify cell growth characteristics. Expression analysis stratified the cell lines in 2 main clusters, hormone-dependent cell lines expressing ESR and PGR and a hormone-independent cluster. A significant correlation was observed between the expression levels of ESR and PGR and their expression was also associated with that of GPER. Furthermore, the expression of GPER was associated with that of EPOR, suggesting the connection between this orphan G protein and EPO signaling. A negative correlation between EPOR and CSF2RB expression was observed, questioning the involvement of these two receptors in the hetero-receptor formation. rHuEPO treatment only influenced the hormone-independent cell lines, since only the MDA-MB-231, SKBR3 and Hs578T cells responded to the treatment. The correlation between the expression of the analyzed receptors suggests that the receptors may interact in order to activate signaling pathways or to evade their inhibition. Therefore, breast cancer classification upon ESR, PGR and human epidermal growth factor receptor 2 (HER2) may not be sufficient for the selection of suitable treatment protocol. The expression of EPOR, GPER and EPHB4 may be considered as additional classification factors.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sytkowski JA: Erythropoietin: Blood, Brain and Beyond. Wiley-VCH; Boston, MA: 2004, View Article : Google Scholar

2 

Debeljak N and Sytkowski AJ: EpoR. UCSD-Nature Molecule Pages. 2007, View Article : Google Scholar

3 

Jelkmann W and Wagner K: Beneficial and ominous aspects of the pleiotropic action of erythropoietin. Ann Hematol. 83:673–686. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Debeljak N and Sytkowski AJ: Erythropoietin: new approaches to improved molecular designs and therapeutic alternatives. Curr Pharm Des. 14:1302–1310. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Szenajch J, Wcislo G, Jeong JY, Szczylik C and Feldman L: The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells: from clinic to bench - a critical review. Biochim Biophys Acta. 1806:82–95. 2010.PubMed/NCBI

6 

Acs G, Acs P, Beckwith SM, et al: Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res. 61:3561–3565. 2001.PubMed/NCBI

7 

Arcasoy MO, Amin K, Karayal AF, et al: Functional significance of erythropoietin receptor expression in breast cancer. Lab Invest. 82:911–918. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Eschbach JW, Egrie JC, Downing MR, Browne JK and Adamson JW: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med. 316:73–78. 1987. View Article : Google Scholar : PubMed/NCBI

9 

Schrijvers D, De Samblanx H and Roila F: ESMO Guidelines Working Group: Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients: Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients: ESMO Clinical Practice Guidelines for use. Ann Oncol. 21(Suppl 5): v244–v247. 2010. View Article : Google Scholar

10 

Latini R, Brines M and Fiordaliso F: Do non-hemopoietic effects of erythropoietin play a beneficial role in heart failure? Heart Fail Rev. 13:415–423. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Moore EM, Bellomo R and Nichol AD: Erythropoietin as a novel brain and kidney protective agent. Anaesth Intensive Care. 39:356–372. 2011.PubMed/NCBI

12 

Sytkowski AJ: The neurobiology of erythropoietin. Cell Mol Neurobiol. 31:931–937. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Brines M, Grasso G, Fiordaliso F, et al: Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci USA. 101:14907–14912. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Noren NK and Pasquale EB: Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67:3994–3997. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Jackson DB, Stein M, Voss H, Brock S, Danes CG and Sood A: Tissue protective erythropoietin receptor (nepor) and methods to use. Patent WO 2009/068677. Filed November 28, 2008; issued April 18, 2012.

16 

Kumar SR, Singh J, Xia G, et al: Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol. 169:279–293. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Henke M, Laszig R, Rube C, et al: Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet. 362:1255–1260. 2003. View Article : Google Scholar

18 

Leyland-Jones B, Semiglazov V, Pawlicki M, et al: Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemo-therapy: a survival study. J Clin Oncol. 23:5960–5972. 2005. View Article : Google Scholar

19 

Sytkowski AJ: Does erythropoietin have a dark side? Epo signaling and cancer cells. Sci STKE. 2007.pe382007.PubMed/NCBI

20 

Schnitt SJ: Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy. Mod Pathol. 23(Suppl 2): S60–S64. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Thomas P, Pang Y, Filardo EJ and Dong J: Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 146:624–632. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Thomas P: Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions. Front Neuroendocrinol. 29:292–312. 2008. View Article : Google Scholar

23 

Levin ER: Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol. 19:1951–1959. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Bjornstrom L and Sjoberg M: Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 19:833–842. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Vasudevan N and Pfaff DW: Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles. Endocr Rev. 28:1–19. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC and Levin ER: A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 282:22278–22288. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Kumar P, Wu Q, Chambliss KL, et al: Direct interactions with G α i and G βγ mediate nongenomic signaling by estrogen receptor α. Mol Endocrinol. 21:1370–1380. 2007.

28 

Hammes SR and Levin ER: Minireview: Recent advances in extra-nuclear steroid receptor actions. Endocrinology. 152:4489–4495. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Levin ER: G protein-coupled receptor 30: estrogen receptor or collaborator? Endocrinology. 150:1563–1565. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Pelekanou V, Kampa M, Kafousi M, et al: Erythropoietin and its receptor in breast cancer: correlation with steroid receptors and outcome. Cancer Epidemiol Biomarkers Prev. 16:2016–2023. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Larsson AM, Jirstrom K, Fredlund E, et al: Erythropoietin receptor expression and correlation to tamoxifen response and prognosis in breast cancer. Clin Cancer Res. 15:5552–5559. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Volgger B, Kurz K, Zoschg K, et al: Importance of erythropoetin receptor expression in tumour tissue for the clinical course of breast cancer. Anticancer Res. 30:3721–3726. 2010.PubMed/NCBI

33 

Filardo EJ, Quinn JA and Sabo E: Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor. Steroids. 73:870–873. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Kampa M, Pelekanou V and Castanas E: Membrane-initiated steroid action in breast and prostate cancer. Steroids. 73:953–960. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Pelekanou V, Notas G, Sanidas E, Tsapis A, Castanas E and Kampa M: Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR. Mol Oncol. 4:135–149. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Notas G, Kampa M, Pelekanou V and Castanas E: Interplay of estrogen receptors and GPR30 for the regulation of early membrane initiated transcriptional effects: a pharmacological approach. Steroids. 77:943–950. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Xiao Z, Carrasco R, Kinneer K, et al: EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: implications for EphB4 as a cancer target. Cancer Biol Ther. 13:630–637. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Hevir N, Trošt N, Debeljak N and Rižner TL: Expression of estrogen and progesterone receptors and estrogen metabolizing enzymes in different breast cancer cell lines. Chem Biol Interact. 191:206–216. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Bustin SA, Benes V, Garson JA, et al: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 55:611–622. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Kutuk O, Arisan ED, Tezil T, Shoshan MC and Basaga H: Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis. 30:1517–1527. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Abramoff MD, Magelhaes PJ and Ram SJ: Image Processing with ImageJ. Biophotonics International. 11:36–42. 2004.

42 

Jelkmann W, Bohlius J, Hallek M and Sytkowski AJ: The erythropoietin receptor in normal and cancer tissues. Crit Rev Oncol Hematol. 67:39–61. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Vivacqua A, Bonofiglio D, Recchia AG, et al: The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol. 20:631–646. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Albanito L, Madeo A, Lappano R, et al: G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res. 67:1859–1866. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Kanda N and Watanabe S: 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression. J Invest Dermatol. 123:319–328. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Michalides R, Griekspoor A, Balkenende A, et al: Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell. 5:597–605. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Shou J, Massarweh S, Osborne CK, et al: Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst. 96:926–935. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Ignatov A, Ignatov T, Roessner A, Costa SD and Kalinski T: Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells. Breast Cancer Res Treat. 123:87–96. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Liang K, Esteva FJ, Albarracin C, et al: Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 18:423–435. 2010. View Article : Google Scholar

50 

Cui X, Schiff R, Arpino G, Osborne CK and Lee AV: Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol. 23:7721–7735. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Trošt N, Juvan P, Serša G and Debeljak N: Contrasting effect of erythropoietin on breast cancer cell response to cisplatin induced cytotoxicity. Radiol Oncol. 46:213–225. 2012.PubMed/NCBI

52 

Hui L, Zheng Y, Yan Y, Bargonetti J and Foster DA: Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D. Oncogene. 25:7305–7310. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Trošt N, Hevir N, Rižner TL and Debeljak N: Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines. Int J Mol Med 31: 717-725, 2013.
APA
Trošt, N., Hevir, N., Rižner, T.L., & Debeljak, N. (2013). Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines. International Journal of Molecular Medicine, 31, 717-725. https://doi.org/10.3892/ijmm.2013.1231
MLA
Trošt, N., Hevir, N., Rižner, T. L., Debeljak, N."Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines". International Journal of Molecular Medicine 31.3 (2013): 717-725.
Chicago
Trošt, N., Hevir, N., Rižner, T. L., Debeljak, N."Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines". International Journal of Molecular Medicine 31, no. 3 (2013): 717-725. https://doi.org/10.3892/ijmm.2013.1231
Copy and paste a formatted citation
x
Spandidos Publications style
Trošt N, Hevir N, Rižner TL and Debeljak N: Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines. Int J Mol Med 31: 717-725, 2013.
APA
Trošt, N., Hevir, N., Rižner, T.L., & Debeljak, N. (2013). Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines. International Journal of Molecular Medicine, 31, 717-725. https://doi.org/10.3892/ijmm.2013.1231
MLA
Trošt, N., Hevir, N., Rižner, T. L., Debeljak, N."Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines". International Journal of Molecular Medicine 31.3 (2013): 717-725.
Chicago
Trošt, N., Hevir, N., Rižner, T. L., Debeljak, N."Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines". International Journal of Molecular Medicine 31, no. 3 (2013): 717-725. https://doi.org/10.3892/ijmm.2013.1231
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team