Thrombin-induced TGF-β1 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage

  • Authors:
    • Tong Li
    • Peng Zhang
    • Bin Yuan
    • Dongliang Zhao
    • Yueqin Chen
    • Xinzhong Zhang
  • View Affiliations

  • Published online on: January 22, 2013     https://doi.org/10.3892/ijmm.2013.1253
  • Pages: 660-666
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Abstract

The mechanism of communicating hydrocephalus after subarachnoid hemorrhage (SAH) remains unclear. Revealing a signaling cascade may provide significant insights into the molecular etiology of the accumulation of cerebrospinal fluid (CSF) in cerebral compartments during SAH. To investigate the mechanism of the communicating hydrocephalus following SAH, we infused CSF with thrombin (TH), resulting in proinflammatory and proliferative responses in rat meninges of SAH. The effect of TH could be completely blocked by a transforming growth factor β1 (TGF-β1) inhibitor, SB-431542, suggesting that TH-stimulated proliferation of meninges is through the TGF-β1 signaling pathway. The cascade of TGF β1-Smad3 was significantly upregulated by TH, which, in turn, stimulated the proliferation of subarachnoid meninges. TH-induced overexpression of TGF-β1 and activation of its downstream factors might be a mechanism of communicating hydrocephalus after SAH.
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March 2013
Volume 31 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Li T, Zhang P, Yuan B, Zhao D, Chen Y and Zhang X: Thrombin-induced TGF-β1 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage. Int J Mol Med 31: 660-666, 2013
APA
Li, T., Zhang, P., Yuan, B., Zhao, D., Chen, Y., & Zhang, X. (2013). Thrombin-induced TGF-β1 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage. International Journal of Molecular Medicine, 31, 660-666. https://doi.org/10.3892/ijmm.2013.1253
MLA
Li, T., Zhang, P., Yuan, B., Zhao, D., Chen, Y., Zhang, X."Thrombin-induced TGF-β1 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage". International Journal of Molecular Medicine 31.3 (2013): 660-666.
Chicago
Li, T., Zhang, P., Yuan, B., Zhao, D., Chen, Y., Zhang, X."Thrombin-induced TGF-β1 pathway: A cause of communicating hydrocephalus post subarachnoid hemorrhage". International Journal of Molecular Medicine 31, no. 3 (2013): 660-666. https://doi.org/10.3892/ijmm.2013.1253