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Article

Alleviation of asthma-related symptoms by a derivative of L-allo threonine

  • Authors:
    • Jin-Chul Heo
    • Sang-Han Lee
  • View Affiliations / Copyright

    Affiliations: Food and Bio-Industry Research Institute, Kyungpook National University, Daegu 702-701, Republic of Korea, Department of Food Science and Biotechnology,Graduate School, Kyungpook National University, Daegu 702-701, Republic of Korea
  • Pages: 881-887
    |
    Published online on: February 1, 2013
       https://doi.org/10.3892/ijmm.2013.1265
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Abstract

Chronic asthma is characterized by inflammatory cell infiltration and tissue remodeling, leading to subepithelial inflammation. In order to evaluate the anti-asthmatic activity of LX519290, a derivative of L-allo threonine, we performed several in vitro and in vivo anti-asthmatic assays. Using ovalbumin (OVA)-sensitized C57BL/6 mice, the effects of LX519290 on lung inflammation and cytokine expression in the asthmatic animals were analyzed. Treatment with this compound increased IFN-γ and decreased IL-10 mRNA expression. LX519290 potently decreased, not only immune cell infiltration in the lung, but also IL-4 and IL-13 cytokine levels in the serum of OVA-treated mice. The results demonstrated that LX519290 decreased the pathogenesis of chronic airway injury. Evidence from our model of OVA-induced asthma demonstrated that LX519290 inhibits immune cell infiltration, mucus hypersecretion, and inflammatory cytokine production. Collectively, our findings suggest that LX519290 has the potential to ameliorate asthmatic symptoms by treating inflammatory factors in the lung.
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1 

Holgate ST: The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev. 242:205–219. 2011. View Article : Google Scholar : PubMed/NCBI

2 

von Mutius E: Gene-environment interactions in asthma. J Allergy Clin Immunol. 123:3–11. 2009.PubMed/NCBI

3 

Walsh GM: Emerging drugs for asthma. Expert Opin Emerg Drugs. 13:643–653. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad ME, Wong A, Collins M, Donaldson DD, Grusby MJ and Wynn TA: Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med. 197:687–701. 2003. View Article : Google Scholar : PubMed/NCBI

5 

López-Torres M, Gil P and Barja de Quiroga G: Effect of hyperoxia acclimation on catalase and glutathione peroxidase activities and in vivo peroxidation products in various tissues of the frog Rana ridibunda perezi. J Exp Zool. 248:7–18. 1998.PubMed/NCBI

6 

Møller S, Iversen JS, Krag A, Bie P, Kjaer A and Bendtsen F: Reduced baroreflex sensitivity and pulmonary dysfunction in alcoholic cirrhosis: effect of hyperoxia. Am J Physiol Gastrointest Liver Physiol. 299:G784–G790. 2010.PubMed/NCBI

7 

Olin AC, Ljungkvist G, Bake B, Hagberg S, Henriksson L and Torén K: Exhaled nitric oxide among pulpmill workers reporting gassing incidents involving ozone and chlorine dioxide. Eur Respir J. 14:828–831. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Moraes TJ, Zurawska JH and Downey GP: Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 13:21–27. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Kim SW, Lee SH, Heo JC, Lee EJ and Kim DM: Pharmaceutical and functional food composition for treating, preventing or improving respiratory diseases comprising amino acid-based derivatives. Korea Patent Registration # 10-1076769. 1–17. November 19–2011.

10 

Baker DH, Webel DM and Fernandez SR: D-allo threonine has no growth promoting efficacy for chicks. Poult Sci. 77:1397–1399. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Zhao H, Hamase K, Morikawa A, Qiu Z and Zaitsu K: Determination of D- and L-enantiomers of threonine and allo-threonine in mammals using two-step high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 810:245–250. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Nakajima M, Inukai M, Haneishi T, Terahara A, Arai M, Kinoshita T and Tamura C: Globomycin, a new peptide antibiotic with spheroplast-forming activity. III Structural determination of globomycin. J Antibiot. 31:426–432. 1978. View Article : Google Scholar : PubMed/NCBI

13 

Makart S, Bechtold M and Panke S: Model-based characterization of an amino acid racemase from Pseudomonas putida DSM 3263 for application in medium-constrained continuous processes. J Biotechnol. 130:402–410. 2007.

14 

Heo JC, Son HU, Kim SL and Lee SH: A derivative of L-allo threonine alleviates 2,4-dinitrofluorobenzene-induced atopic dermatitis indications. Biosci Biotechnol Biochem. 76:2012–2015. 2012.PubMed/NCBI

15 

Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:109–110. 1983. View Article : Google Scholar : PubMed/NCBI

16 

Heo JC, Rho JR, Kim TH, Kim SY and Lee SH: An aqueous extract of green tea Camellia sinensis increase expression of Th-1 cell-specific anti-asthmatic markers. Int J Mol Med. 22:763–768. 2008.PubMed/NCBI

17 

Heo JC, Woo SU, Kweon MA, Park JY, Lee HK, Son M, Rho JR and Lee SH: Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo. Int J Mol Med. 21:57–61. 2008.

18 

Heo JC, Park CH, Lee HJ, Kim SO, Kim TH and Lee SH: Amelioration of asthmatic inflammation by an aqueous extract of Spinacia oleracea Linn. Int J Mol Med. 25:409–415. 2010.PubMed/NCBI

19 

Liu W, Liang Q, Balzar S, Wenzel S, Gorska M and Alam R: Cell-specific activation profile of extracellular signal regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J Allergy Clin Immunol. 121:893–902. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Valko M, Izakovic M, Mazur M, Rhodes CJ and Telser J: Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 266:37–56. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Korkina LG, Mikhalśhik E, Suprun MV, Pastore S and Dal Toso R: Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides. Cell Mol Biol. 53:84–91. 2007.

22 

Fang YZ, Yang S and Wu G: Free radicals, antioxidants, and nutrition. Nutrition. 18:872–879. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Dut R, Dizdar EA, Birben E, Sackesen C, Soyer OU, Besler T and Kalayci O: Oxidative stress and its determinants in the airways of children with asthma. Allergy. 63:1605–1609. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Russo C, Arcidiacono G and Polosa R: Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma. Fundam Clin Pharmacol. 20:9–19. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR and Lo D: Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol. 162:2477–2487. 1999.PubMed/NCBI

26 

Huang CH, Loo EX, Kuo IC, Soh GH, Goh DL, Lee BW and Chua KY: Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2 cell line can be effectively attenuated by IL-35. J Immunol. 187:462–471. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H and Cook DN: IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol. 129:207–215. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Wu Z, MacPhee IA and Oliveira DB: Reactive oxygen species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. Curr Pharm Des. 10:899–913. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Munitz A, Brandt EB, Mingler M, Finkelman FD and Rothenberg ME: Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci USA. 105:7240–7245. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Chen JL, Lacomis L, Erdjument-Bromage H, Tempst P and Stamnes M: Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. FEBS Lett. 566:281–286. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Doherty TA, Soroosh P, Broide DH and Croft M: CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol. 296:L229–L235. 2009.PubMed/NCBI

32 

Asai K, Moriwaki S and Maeda-Yamamoto M: Enhancement of interleukin-2 production in CCRF-CEM, human T-cell leukemia, by tea flavonols. Jpn Agric Res Q. 39:51–55. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Heo J and Lee S: Alleviation of asthma-related symptoms by a derivative of L-allo threonine . Int J Mol Med 31: 881-887, 2013.
APA
Heo, J., & Lee, S. (2013). Alleviation of asthma-related symptoms by a derivative of L-allo threonine . International Journal of Molecular Medicine, 31, 881-887. https://doi.org/10.3892/ijmm.2013.1265
MLA
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31.4 (2013): 881-887.
Chicago
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31, no. 4 (2013): 881-887. https://doi.org/10.3892/ijmm.2013.1265
Copy and paste a formatted citation
x
Spandidos Publications style
Heo J and Lee S: Alleviation of asthma-related symptoms by a derivative of L-allo threonine . Int J Mol Med 31: 881-887, 2013.
APA
Heo, J., & Lee, S. (2013). Alleviation of asthma-related symptoms by a derivative of L-allo threonine . International Journal of Molecular Medicine, 31, 881-887. https://doi.org/10.3892/ijmm.2013.1265
MLA
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31.4 (2013): 881-887.
Chicago
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31, no. 4 (2013): 881-887. https://doi.org/10.3892/ijmm.2013.1265
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