Alleviation of asthma-related symptoms by a derivative of L-allo threonine

  • Authors:
    • Jin-Chul Heo
    • Sang-Han Lee
  • View Affiliations

  • Published online on: February 1, 2013     https://doi.org/10.3892/ijmm.2013.1265
  • Pages: 881-887
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Abstract

Chronic asthma is characterized by inflammatory cell infiltration and tissue remodeling, leading to subepithelial inflammation. In order to evaluate the anti-asthmatic activity of LX519290, a derivative of L-allo threonine, we performed several in vitro and in vivo anti-asthmatic assays. Using ovalbumin (OVA)-sensitized C57BL/6 mice, the effects of LX519290 on lung inflammation and cytokine expression in the asthmatic animals were analyzed. Treatment with this compound increased IFN-γ and decreased IL-10 mRNA expression. LX519290 potently decreased, not only immune cell infiltration in the lung, but also IL-4 and IL-13 cytokine levels in the serum of OVA-treated mice. The results demonstrated that LX519290 decreased the pathogenesis of chronic airway injury. Evidence from our model of OVA-induced asthma demonstrated that LX519290 inhibits immune cell infiltration, mucus hypersecretion, and inflammatory cytokine production. Collectively, our findings suggest that LX519290 has the potential to ameliorate asthmatic symptoms by treating inflammatory factors in the lung.
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April 2013
Volume 31 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Heo J and Lee S: Alleviation of asthma-related symptoms by a derivative of L-allo threonine . Int J Mol Med 31: 881-887, 2013.
APA
Heo, J., & Lee, S. (2013). Alleviation of asthma-related symptoms by a derivative of L-allo threonine . International Journal of Molecular Medicine, 31, 881-887. https://doi.org/10.3892/ijmm.2013.1265
MLA
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31.4 (2013): 881-887.
Chicago
Heo, J., Lee, S."Alleviation of asthma-related symptoms by a derivative of L-allo threonine ". International Journal of Molecular Medicine 31, no. 4 (2013): 881-887. https://doi.org/10.3892/ijmm.2013.1265