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International Journal of Molecular Medicine
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April 2013 Volume 31 Issue 4

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Article

Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease

  • Authors:
    • Jianhua Jiang
    • Juean Jiang
    • Yuanyi Zuo
    • Zhenlun Gu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Medical College of Soochow University, Suzhou Institute of Chinese Materia Medica, Suzhou 215007, P.R. China, Department of Special Requirements Ward, The First Affiliated Hospital of Soochow University, Suzhou 215006, P.R. China
  • Pages: 825-832
    |
    Published online on: February 20, 2013
       https://doi.org/10.3892/ijmm.2013.1280
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Abstract

Parkinson's disease (PD) is a neurodegenerative disease, in which oxidative stress and mitochondrial dysfunction are responsible for neuronal apoptosis. Rapamycin plays a crucial role in reducing oxidative stress and protecting the mitochondria. However, its protective role in PD has not yet been fully elucidated. In this study, we report that pre-treatment with rapamycin provides behavioral improvements, protects against the loss of dopaminergic neurons, and alleviates mitochondrial ultrastructural injuries in a rat model of PD. Peroxide levels were lower and antioxidant activities were higher in PD rats pre-treated with rapamycin compared to the PD rats pre-treated with the vehicle. Furthermore, pre-treatment with rapamycin significantly elevated the expression of anti-apoptotic markers and reduced the levels of pro-apoptotic markers compared to pre-treatment with the vehicle. In conclusion, our results demonstrated that rapamycin reduced oxidative stress and alleviated mitochondrial injuries in the 6-hydroxydopamine (6-OHDA)-induced rat model of PD, which may subsequently contribute to its anti-apoptotic effects. The ability of rapamycin to exhibit neuroprotection in a rat model of PD may be related to its antioxidant capabilities.
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1 

Dauer W and Przedborski S: Parkinson’s disease: mechanisms and models. Neuron. 39:889–909. 2003.

2 

Marras C and Lang A: Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain. Neurology. 70:1996–2003. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Levy OA, Malagelada C and Greene LA: Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps. Apoptosis. 14:478–500. 2009.

4 

Smith MP and Cass WA: Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson’s disease. Neuroscience. 144:1057–1066. 2007.PubMed/NCBI

5 

Exner N, Lutz AK, Haass C and Winklhofer KF: Mitochondrial dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological consequences. EMBO J. 31:3038–3062. 2012.

6 

Yamato M, Kudo W, Shiba T, Yamada KI, Watanabe T and Utsumi H: Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism. Free Radic Res. 44:249–257. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Lee JE, Park JH, Shin IC and Koh HC: Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos. Toxicol Appl Pharmacol. 263:148–162. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Hori A, Yoshida M, Shibata T and Ling F: Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication. Nucleic Acids Res. 37:749–761. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Noda T and Ohsumi Y: Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem. 273:3963–3966. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Sudarsanam S and Johnson DE: Functional consequences of mTOR inhibition. Curr Opin Drug Discov Devel. 13:31–40. 2010.PubMed/NCBI

11 

Ravikumar B, Duden R and Rubinsztein DC: Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet. 11:1107–1117. 2002. View Article : Google Scholar

12 

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 36:585–595. 2004. View Article : Google Scholar

13 

Pan T, Kondo S, Zhu W, Xie W, Jankovic J and Le W: Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol Dis. 32:16–25. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S and Greene LA: Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson’s disease. J Neurosci. 30:1166–1175. 2010.PubMed/NCBI

15 

Ravikumar B, Berger Z, Vacher C, O’Kane CJ and Rubinsztein DC: Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet. 15:1209–1216. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Marobbio CM, Pisano I, Porcelli V, Lasorsa FM and Palmieri L: Rapamycin reduces oxidative stress in frataxin-deficient yeast cells. Mitochondrion. 12:156–161. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Siddiqui A, Hanson I and Andersen JK: Mao-B elevation decreases parkin’s ability to efficiently clear damaged mitochondria: protective effects of rapamycin. Free Radic Res. 46:1011–1018. 2012.PubMed/NCBI

18 

Kofman AE, McGraw MR and Payne CJ: Rapamycin increases oxidative stress response gene expression in adult stem cells. Aging (Albany NY). 4:279–289. 2012.PubMed/NCBI

19 

Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, et al: Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci. 31:453–460. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Paxinos G and Watson C: The Rat Brain in Stereotaxic Coordinates. 6th edition. Academic Press; London: 2007

21 

Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, Balaban RS, et al: The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem. 281:27643–27652. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Wullschleger S, Loewith R and Hall MN: TOR signaling in growth and metabolism. Cell. 124:471–484. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Pan T, Rawal P, Wu Y, Xie W, Jankovic J and Le W: Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience. 164:541–551. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Hall ED, Detloff MR, Johnson K and Kupina NC: Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. J Neurotrauma. 21:9–20. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Smith MP and Cass WA: GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson’s disease. Neurosci Lett. 412:259–263. 2007.PubMed/NCBI

26 

Long J, Liu C, Sun L, Gao H and Liu J: Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res. 34:786–794. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Onyango IG: Mitochondrial dysfunction and oxidative stress in Parkinson’s disease. Neurochem Res. 33:589–597. 2008.

28 

Martinou JC and Youle RJ: Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 21:92–101. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kirkland RA and Franklin JL: Bax, reactive oxygen, and cytochrome c release in neuronal apoptosis. Antioxid Redox Signal. 5:589–596. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Bhagwat SV and Crew AP: Novel inhibitors of mTORC1 and mTORC2. Curr Opin Investig Drugs. 11:638–645. 2010.PubMed/NCBI

31 

Santini E, Heiman M, Greengard P, Valjent E and Fisone G: Inhibition of mTOR signaling in Parkinson’s disease prevents L-DOPA-induced dyskinesia. Sci Signal. 2:ra362009.

32 

Lin MT and Beal MF: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443:787–795. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Lee J, Giordano S and Zhang J: Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 441:523–540. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang J, Jiang J, Zuo Y and Gu Z: Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. Int J Mol Med 31: 825-832, 2013.
APA
Jiang, J., Jiang, J., Zuo, Y., & Gu, Z. (2013). Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. International Journal of Molecular Medicine, 31, 825-832. https://doi.org/10.3892/ijmm.2013.1280
MLA
Jiang, J., Jiang, J., Zuo, Y., Gu, Z."Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease". International Journal of Molecular Medicine 31.4 (2013): 825-832.
Chicago
Jiang, J., Jiang, J., Zuo, Y., Gu, Z."Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease". International Journal of Molecular Medicine 31, no. 4 (2013): 825-832. https://doi.org/10.3892/ijmm.2013.1280
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Jiang J, Zuo Y and Gu Z: Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. Int J Mol Med 31: 825-832, 2013.
APA
Jiang, J., Jiang, J., Zuo, Y., & Gu, Z. (2013). Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. International Journal of Molecular Medicine, 31, 825-832. https://doi.org/10.3892/ijmm.2013.1280
MLA
Jiang, J., Jiang, J., Zuo, Y., Gu, Z."Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease". International Journal of Molecular Medicine 31.4 (2013): 825-832.
Chicago
Jiang, J., Jiang, J., Zuo, Y., Gu, Z."Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease". International Journal of Molecular Medicine 31, no. 4 (2013): 825-832. https://doi.org/10.3892/ijmm.2013.1280
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