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Article

Piceatannol inhibits mast cell-mediated allergic inflammation

  • Authors:
    • Yu-Jin Ko
    • Hui-Hun Kim
    • Eun-Jung Kim
    • Yoshinori Katakura
    • Won-Sup Lee
    • Gon-Sup Kim
    • Chung-Ho Ryu
  • View Affiliations / Copyright

    Affiliations: Division of Applied Life Sciences (BK 21 Program), Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 660-701, Republic of Korea, Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan, Department of Internal Medicine, Institute of Health Sciences and Gyeongnam Regional Cancer Center, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, School of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University School of Medicine, Jinju 660-701, Republic of Korea
  • Pages: 951-958
    |
    Published online on: February 21, 2013
       https://doi.org/10.3892/ijmm.2013.1283
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Abstract

Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro‑inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro‑inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Ko Y, Kim H, Kim E, Katakura Y, Lee W, Kim G and Ryu C: Piceatannol inhibits mast cell-mediated allergic inflammation. Int J Mol Med 31: 951-958, 2013.
APA
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., & Ryu, C. (2013). Piceatannol inhibits mast cell-mediated allergic inflammation. International Journal of Molecular Medicine, 31, 951-958. https://doi.org/10.3892/ijmm.2013.1283
MLA
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., Ryu, C."Piceatannol inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 31.4 (2013): 951-958.
Chicago
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., Ryu, C."Piceatannol inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 31, no. 4 (2013): 951-958. https://doi.org/10.3892/ijmm.2013.1283
Copy and paste a formatted citation
x
Spandidos Publications style
Ko Y, Kim H, Kim E, Katakura Y, Lee W, Kim G and Ryu C: Piceatannol inhibits mast cell-mediated allergic inflammation. Int J Mol Med 31: 951-958, 2013.
APA
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., & Ryu, C. (2013). Piceatannol inhibits mast cell-mediated allergic inflammation. International Journal of Molecular Medicine, 31, 951-958. https://doi.org/10.3892/ijmm.2013.1283
MLA
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., Ryu, C."Piceatannol inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 31.4 (2013): 951-958.
Chicago
Ko, Y., Kim, H., Kim, E., Katakura, Y., Lee, W., Kim, G., Ryu, C."Piceatannol inhibits mast cell-mediated allergic inflammation". International Journal of Molecular Medicine 31, no. 4 (2013): 951-958. https://doi.org/10.3892/ijmm.2013.1283
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