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Review

High mobility group box 1 and kidney diseases (Review)

  • Authors:
    • Ping Zhu
    • Li Xie
    • Hua-Sheng Ding
    • Quan Gong
    • Jian Yang
    • Lin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, P.R. China, Department of General Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, P.R. China, Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, P.R. China, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
  • Pages: 763-768
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    Published online on: February 25, 2013
       https://doi.org/10.3892/ijmm.2013.1286
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Abstract

High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. However, extracellular HMGB1, which is actively or passively released under different conditions, can act as a key inflammatory mediator through MyD88/mitogen-activated protein kinase signaling by binding to its receptors including the receptor for advanced glycation end products or Toll-like receptors. A growing body of evidence indicates that HMGB1 plays an important role in kidney diseases, such as glomerulonephritis, lupus nephritis, antineutrophilic cytoplasmatic antibody-associated vaculitis, diabetic nephropathy, renal allograft rejection and acute kidney injury. In this review, we focus on the biology of HMGB1 and the association of HMGB1 with kidney diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu P, Xie L, Ding H, Gong Q, Yang J and Yang L: High mobility group box 1 and kidney diseases (Review). Int J Mol Med 31: 763-768, 2013.
APA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., & Yang, L. (2013). High mobility group box 1 and kidney diseases (Review). International Journal of Molecular Medicine, 31, 763-768. https://doi.org/10.3892/ijmm.2013.1286
MLA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31.4 (2013): 763-768.
Chicago
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31, no. 4 (2013): 763-768. https://doi.org/10.3892/ijmm.2013.1286
Copy and paste a formatted citation
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Spandidos Publications style
Zhu P, Xie L, Ding H, Gong Q, Yang J and Yang L: High mobility group box 1 and kidney diseases (Review). Int J Mol Med 31: 763-768, 2013.
APA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., & Yang, L. (2013). High mobility group box 1 and kidney diseases (Review). International Journal of Molecular Medicine, 31, 763-768. https://doi.org/10.3892/ijmm.2013.1286
MLA
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31.4 (2013): 763-768.
Chicago
Zhu, P., Xie, L., Ding, H., Gong, Q., Yang, J., Yang, L."High mobility group box 1 and kidney diseases (Review)". International Journal of Molecular Medicine 31, no. 4 (2013): 763-768. https://doi.org/10.3892/ijmm.2013.1286
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