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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2013 Volume 31 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway

  • Authors:
    • Yuanyuan Zhang
    • Jie Zhu
    • Xuejun Hong
    • Yunlian Zhou
    • Keming Ren
    • Xiaoli Shu
    • Qingqing Wang
  • View Affiliations / Copyright

    Affiliations: The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310031, P.R. China, Clinical Laboratory of Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China, Xuancheng Blood Center, Xuancheng, Anhui 242000, P.R. China, Institute of Immunology, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 1319-1326
    |
    Published online on: April 3, 2013
       https://doi.org/10.3892/ijmm.2013.1326
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Abstract

Tumor-associated antigen receptor-binding cancer antigen expressed on SiSo cells (RCAS1) has been identified as an estrogen-responsive gene and reportedly acts as a ligand for a putative receptor present in a variety of human cell lines and peripheral lymphocytes, thus leading them to apoptosis. In this study, we investigated the biological function of RCAS1 in vitro in inducing the apoptosis of immune cells. We detected the expression of the RCAS1 receptor (RCAS1R) in the cell lines, and investigated the mechanisms behind the apoptosis induced by RCAS1. HeLa cells were transfected with recombinant adenovirus Ad-RCAS1. RCAS1 induced the apoptosis of activated T cells, K562 cells and phytohemagglutinin (PHA)-activated Jurkat cells via the RCAS1-RCAS1R pathway. The expression of RCAS1R was induced. The intracellular overexpression of RCAS1 inhibited the growth of Jurkat and K562 cells. The expression of RCAS1 negatively correlated with the expression of glycogen synthase kinase 3β (GSK3β), but positively correlated with the expression of phosphorylated GSK3β (phGSK3β). RCAS1 expression was identified as a brown staining pattern in the breast cancer specimens. These findings may provide insight into the mechanisms through which tumor cells escape from immune surveillance.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhu J, Hong X, Zhou Y, Ren K, Shu X and Wang Q: The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. Int J Mol Med 31: 1319-1326, 2013.
APA
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., & Wang, Q. (2013). The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. International Journal of Molecular Medicine, 31, 1319-1326. https://doi.org/10.3892/ijmm.2013.1326
MLA
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., Wang, Q."The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway". International Journal of Molecular Medicine 31.6 (2013): 1319-1326.
Chicago
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., Wang, Q."The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway". International Journal of Molecular Medicine 31, no. 6 (2013): 1319-1326. https://doi.org/10.3892/ijmm.2013.1326
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhu J, Hong X, Zhou Y, Ren K, Shu X and Wang Q: The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. Int J Mol Med 31: 1319-1326, 2013.
APA
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., & Wang, Q. (2013). The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. International Journal of Molecular Medicine, 31, 1319-1326. https://doi.org/10.3892/ijmm.2013.1326
MLA
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., Wang, Q."The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway". International Journal of Molecular Medicine 31.6 (2013): 1319-1326.
Chicago
Zhang, Y., Zhu, J., Hong, X., Zhou, Y., Ren, K., Shu, X., Wang, Q."The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway". International Journal of Molecular Medicine 31, no. 6 (2013): 1319-1326. https://doi.org/10.3892/ijmm.2013.1326
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