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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June 2013 Volume 31 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: Importance of pre-treatment

Nguyen The Cuong, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shigeru Akamatsu, Gen Kuroyanagi, Akira Kondo, Jun Mizutani, Ikuo Wada, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Shinji Ogura
Pages: 1291-1297
Published online on: 11 April 2013

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Article

Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction

Jianye Yang, Yuan Zhou, Bo Liu, Hongfei Wang, Xinling Du
Pages: 1298-1304
Published online on: 05 April 2013

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Article

Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes

Qinghua Dong, Ju-Eun Oh, Jin Kyu Yi, Reuben H. Kim, Ki-Hyuk Shin, Ronald Mitsuyasu, No-Hee Park, Mo K. Kang
Pages: 1305-1312
Published online on: 03 April 2013

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Article

Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO

Peng Gao, Xu Yang, Luckshmanraj Mungur, Sylvanus Kampo, Qingping Wen
Pages: 1313-1318
Published online on: 04 April 2013

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Article

The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway

Yuanyuan Zhang, Jie Zhu, Xuejun Hong, Yunlian Zhou, Keming Ren, Xiaoli Shu, Qingqing Wang
Pages: 1319-1326
Published online on: 03 April 2013

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Article

Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-κB pathway in BV-2 murine microglial cells

Haixia Hu, Zuanfang Li, Xiaoqin Zhu, Ruhui Lin, Jiumao Lin, Jun Peng, Jing Tao, Lidian Chen
Pages: 1327-1332
Published online on: 05 April 2013

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Article

Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain

Fachuan Nie, Jinbao Wang, Dong Su, Ying Shi, Jinmei Chen, Haihui Wang, Wanxiang Qin, Lin Shi
Pages: 1333-1342
Published online on: 11 April 2013

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Article

Molecular cloning, characterization and differential expression of a Sporothrix schenckii STE20-like protein kinase SsSte20

Zhenying Zhang, Binbin Hou, Fangliang Zheng, Xiaohong Yu, Xiaoming Liu
Pages: 1343-1348
Published online on: 16 April 2013

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Article

Tougu Xiaotong capsule inhibits the tidemark replication and cartilage degradation of papain-induced osteoarthritis by the regulation of chondrocyte autophagy

Xihai Li, Wenna Lang, Hongzhi Ye, Fangrong Yu, Huiting Li, Jiashou Chen, Liangliang Cai, Wenlie Chen, Ruhui Lin, Yunmei Huang, Xianxiang Liu
Pages: 1349-1356
Published online on: 09 April 2013

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Article

Anti-inflammatory effects of saponins derived from the roots of Platycodon grandiflorus in lipopolysaccharide‑stimulated BV2 microglial cells

Kyung-Jun Jang, Hong Ki Kim, Min Ho Han, You Na Oh, Hyun-Min Yoon, Yoon Ho Chung, Gi Young Kim, Hye Jin Hwang, Byung Woo Kim, Yung Hyun Choi
Pages: 1357-1366
Published online on: 04 April 2013

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Article

Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice

Wenpeng Dong, Zhen Zhang, Zhengjun Liu, Hao Liu, Xianyue Wang, Shenghui Bi, Xiaowu Wang, Tao Ma, Weida Zhang
Pages: 1367-1374
Published online on: 15 April 2013

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Article

Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression

Guang-Jun Zhang, Hua-Xu Xiao, Hong-Peng Tian, Zuo-Liang Liu, Shu-Sen Xia, Tong Zhou
Pages: 1375-1380
Published online on: 15 April 2013

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Article

Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis

Hong Jiang, Pan Yu, De-Hui Qian, Zhe-Xue Qin, Xue-Jun Sun, Jie Yu, Lan Huang
Pages: 1381-1387
Published online on: 05 April 2013

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Article

p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells

Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Kim
Pages: 1388-1394
Published online on: 05 April 2013

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Article

Allogeneic bone marrow-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury by suppressing oxidative stress and inhibiting apoptosis in rats

Guangxin Jin, Gongcai Qiu, Dequan Wu, Yanhua Hu, Pengfei Qiao, Chengjuan Fan, Feng Gao
Pages: 1395-1401
Published online on: 09 April 2013

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Article

Roles of GINS2 in K562 human chronic myelogenous leukemia and NB4 acute promyelocytic leukemia cells

Yanjun Gao, Shibo Wang, Beizhong Liu, Liang Zhong
Pages: 1402-1410
Published online on: 08 April 2013

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Article

Osteoprotegerin influences the bone resorption activity of osteoclasts

Ying-Xiao Fu, Jian-Hong Gu, Yi-Ran Zhang, Xi-Shuai Tong, Hong-Yan Zhao, Yan Yuan, Xue-Zhong Liu, Jian-Chun Bian, Zong-Ping Liu
Pages: 1411-1417
Published online on: 04 April 2013

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Article

Plastrum testudinis induces γ-globin gene expression through epigenetic histone modifications within the γ-globin gene promoter via activation of the p38 MAPK signaling pathway

Xinhua Qian, Jia Chen, Danhua Zhao, Lishan Guo, Xinlai Qian
Pages: 1418-1428
Published online on: 08 April 2013

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Article

Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes

Junpeng Yang, Jianmin Ren, Jun Song, Fuqiang Liu, Chuanlong Wu, Xuping Wang, Lei Gong, Wenjuan Li, Fang Xiao, Fei Yan, Xinguo Hou, Li Chen
Pages: 1429-1435
Published online on: 15 April 2013

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Article

VEGF suppresses epithelial-mesenchymal transition by inhibiting the expression of Smad3 and miR‑192, a Smad3-dependent microRNA

Jun-Ping Hong, Xue-Mei Li, Ming-Xi Li, Fa-Lei Zheng
Pages: 1436-1442
Published online on: 08 April 2013

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Article

Electroacupuncture promotes chondrocyte proliferation via accelerated G1/S transition in the cell cycle

Yali Huang, Guangwen Wu, Huailing Fan, Jinxia Ye, Xianxiang Liu
Pages: 1443-1448
Published online on: 05 April 2013

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Article

Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy

Zhexing Chang, Guang Shi, Jiqiang Jin, Huatao Guo, Xuefeng Guo, Fangyue Luo, Yuguo Song, Xiaojing Jia
Pages: 1449-1456
Published online on: 16 April 2013

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Article

AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts

Akira Kondo, Takanobu Otsuka, Kenji Kato, Rie Matsushima-Nishiwaki, Gen Kuroyanagi, Jun Mizutani, Haruhiko Tokuda, Osamu Kozawa
Pages: 1457-1462
Published online on: 15 April 2013

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Article

Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells

Jinzhi Lu, Xiong Chen, Yingying Zhang, Jian Xu, Lianglu Zhang, Zhi Li, Wanhong Liu, Jingping Ouyang, Song Han, Xiaohua He
Pages: 1463-1470
Published online on: 05 April 2013

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Article

Anti-inflammatory effects of tectroside on UVB-induced HaCaT cells

Sung-Bae Kim, Ok-Hwa Kang, Dae-Ki Joung, Su-Hyun Mun, Yun-Soo Seo, Mi-Ran Cha, Shi-Yong Ryu, Dong-Won Shin, Dong-Yeul Kwon
Pages: 1471-1476
Published online on: 11 April 2013

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Article

Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen‑ and doxorubicin‑induced autophagy

Vildan Betul Yenigun, Bulent Ozpolat, Gamze Torun Kose
Pages: 1477-1483
Published online on: 10 April 2013

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Article

Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways

Chen Zhu, Hui Qin, Tao Cheng, Hong-Lue Tan, Yong-Yuan Guo, Si-Feng Shi, De-Sheng Chen, Xian-Long Zhang
Pages: 1484-1494
Published online on: 15 April 2013

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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