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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2013 Volume 31 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO

  • Authors:
    • Peng Gao
    • Xu Yang
    • Luckshmanraj Mungur
    • Sylvanus Kampo
    • Qingping Wen
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 1313-1318
    |
    Published online on: April 4, 2013
       https://doi.org/10.3892/ijmm.2013.1328
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Abstract

Acute lung injury (ALI) is among the most common causes of mortality in intensive care units. Recent in vivo and in vitro studies have suggested that mesenchymal stem cells (MSCs) attenuate pulmonary edema and inflammatory factors, but the mechanisms of the effects of MSCs on pulmonary vascular function remain unknown. It is believed that nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) play an essential role in the regulation of vascular function and homeostasis. In the present study, we investigated the effect of adipose tissue-derived stem cells (ADSCs) on pulmonary microvascular endothelial cells (PMVECs) and the lung in a lipopolysaccharide (LPS)-induced ALI model in vitro and in vivo. Our results showed that ADSCs were able to attenuate the severity of ALI and pulmonary edema. Increased expression of the eNOS protein was also observed in pulmonary PMVECs and in the lung following treatment with ADSCs. Furthermore, ADSCs increased the concentration of eNOS-derived NO to remodel ALI. The results suggest that ADSCs may be a promising candidate for ALI treatment through interaction with eNOS and eNOS-derived NO.
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Copy and paste a formatted citation
Spandidos Publications style
Gao P, Yang X, Mungur L, Kampo S and Wen Q: Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO. Int J Mol Med 31: 1313-1318, 2013.
APA
Gao, P., Yang, X., Mungur, L., Kampo, S., & Wen, Q. (2013). Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO. International Journal of Molecular Medicine, 31, 1313-1318. https://doi.org/10.3892/ijmm.2013.1328
MLA
Gao, P., Yang, X., Mungur, L., Kampo, S., Wen, Q."Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO". International Journal of Molecular Medicine 31.6 (2013): 1313-1318.
Chicago
Gao, P., Yang, X., Mungur, L., Kampo, S., Wen, Q."Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO". International Journal of Molecular Medicine 31, no. 6 (2013): 1313-1318. https://doi.org/10.3892/ijmm.2013.1328
Copy and paste a formatted citation
x
Spandidos Publications style
Gao P, Yang X, Mungur L, Kampo S and Wen Q: Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO. Int J Mol Med 31: 1313-1318, 2013.
APA
Gao, P., Yang, X., Mungur, L., Kampo, S., & Wen, Q. (2013). Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO. International Journal of Molecular Medicine, 31, 1313-1318. https://doi.org/10.3892/ijmm.2013.1328
MLA
Gao, P., Yang, X., Mungur, L., Kampo, S., Wen, Q."Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO". International Journal of Molecular Medicine 31.6 (2013): 1313-1318.
Chicago
Gao, P., Yang, X., Mungur, L., Kampo, S., Wen, Q."Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO". International Journal of Molecular Medicine 31, no. 6 (2013): 1313-1318. https://doi.org/10.3892/ijmm.2013.1328
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