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International Journal of Molecular Medicine
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Article

Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction

  • Authors:
    • Jianye Yang
    • Yuan Zhou
    • Bo Liu
    • Hongfei Wang
    • Xinling Du
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China
  • Pages: 1298-1304
    |
    Published online on: April 5, 2013
       https://doi.org/10.3892/ijmm.2013.1332
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Abstract

Trop2 is a cell-surface glycoprotein associated with epithelial carcinomas. Although recent studies indicated that Trop2 is expressed in some stem-like cells, the molecular function of the protein remains largely unknown. In the present study, we observed that acute phase myocardial infarction (MI) induced an increase of c-kit+/Trop2+ cells and found that Trop2 enhanced cardiac c-kit+ cell survival and proliferation via its antiapoptotic activity, due to an elevated activity of ribosomal S6 kinases in the mitogen-activated protein kinase pathway. This study provides insight into better understanding the molecular function of Trop2, which could serve as a potential target for the treatment of MI.
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1 

Lipinski M, Parks DR, Rouse RV and Herzenberg LA: Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci USA. 78:5147–5150. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Kobayashi H, Minami Y, Anami Y, et al: Expression of the GA733 gene family and its relationship to prognosis in pulmonary adenocarcinoma. Virchows Arch. 457:69–76. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Muhlmann G, Spizzo G, Gostner J, et al: TROP2 expression as prognostic marker for gastric carcinoma. J Clin Pathol. 62:152–158. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Wang J, Day R, Dong Y, Weintraub SJ and Michel L: Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7:280–285. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K and Mori M: Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res. 12:3057–3063. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Fong D, Moser P, Krammel C, et al: High expression of TROP2 correlates with poor prognosis in pancreatic cancer. Br J Cancer. 99:1290–1295. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Bignotti E, Todeschini P, Calza S, et al: Trop-2 overexpression as an independent marker for poor overall survival in ovarian carcinoma patients. Eur J Cancer. 46:944–953. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Trerotola M, Rathore S, Goel HL, et al: CD133, Trop-2 and alpha-2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2:135–144. 2010.PubMed/NCBI

9 

Fong D, Spizzo G, Gostner JM, et al: TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol. 21:186–191. 2008.PubMed/NCBI

10 

Okabe M, Tsukahara Y, Tanaka M, et al: Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development. 136:1951–1960. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP and Witte ON: Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci USA. 105:20882–20887. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Ripani E, Sacchetti A, Corda D and Alberti S: Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76:671–676. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Tarnavski O, McMullen JR, Schinke M, Nie Q, Kong S and Izumo S: Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol Genomics. 16:349–360. 2004. View Article : Google Scholar

14 

Han Y, Chen JD, Liu ZM, et al: Functional ion channels in mouse cardiac c-kit(+) cells. Am J Physiol Cell Physiol. 298:C1109–C1117. 2010.

15 

Shimamura A, Ballif BA, Richards SA and Blenis J: Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr Biol. 10:127–135. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Roux PP, Richards SA and Blenis J: Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 23:4796–4804. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Alpert JS, Thygesen K, Antman E and Bassand JP: Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 36:959–969. 2000. View Article : Google Scholar

18 

Berridge MJ, Lipp P and Bootman MD: The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 1:11–21. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Petersen BE, Goff JP, Greenberger JS and Michalopoulos GK: Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology. 27:433–445. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Anversa P, Kajstura J, Leri A and Bolli R: Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation. 113:1451–1463. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Urbanek K, Torella D, Sheikh F, et al: Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA. 102:8692–8697. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Urbanek K, Quaini F, Tasca G, et al: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA. 100:10440–10445. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Levonen AL, Vahakangas E, Koponen JK and Yla-Herttuala S: Antioxidant gene therapy for cardiovascular disease: current status and future perspectives. Circulation. 117:2142–2150. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Brinckmann M, Kaschina E, Altarche-Xifro W, et al: Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells. J Mol Cell Cardiol. 47:66–75. 2009. View Article : Google Scholar

25 

Altarche-Xifro W, Curato C, Kaschina E, et al: Cardiac c-kit+AT2+ cell population is increased in response to ischemic injury and supports cardiomyocyte performance. Stem Cells. 27:2488–2497. 2009.

26 

Padin-Iruegas ME, Misao Y, Davis ME, et al: Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 120:876–887. 2009. View Article : Google Scholar

27 

Lavu M, Gundewar S and Lefer DJ: Gene therapy for ischemic heart disease. J Mol Cell Cardiol. 50:742–750. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Anjum R and Blenis J: The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol. 9:747–758. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Cubas R, Li M, Chen C and Yao Q: Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta. 1796:309–314. 2009.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Zhou Y, Liu B, Wang H and Du X: Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction. Int J Mol Med 31: 1298-1304, 2013.
APA
Yang, J., Zhou, Y., Liu, B., Wang, H., & Du, X. (2013). Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction. International Journal of Molecular Medicine, 31, 1298-1304. https://doi.org/10.3892/ijmm.2013.1332
MLA
Yang, J., Zhou, Y., Liu, B., Wang, H., Du, X."Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction". International Journal of Molecular Medicine 31.6 (2013): 1298-1304.
Chicago
Yang, J., Zhou, Y., Liu, B., Wang, H., Du, X."Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction". International Journal of Molecular Medicine 31, no. 6 (2013): 1298-1304. https://doi.org/10.3892/ijmm.2013.1332
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Zhou Y, Liu B, Wang H and Du X: Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction. Int J Mol Med 31: 1298-1304, 2013.
APA
Yang, J., Zhou, Y., Liu, B., Wang, H., & Du, X. (2013). Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction. International Journal of Molecular Medicine, 31, 1298-1304. https://doi.org/10.3892/ijmm.2013.1332
MLA
Yang, J., Zhou, Y., Liu, B., Wang, H., Du, X."Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction". International Journal of Molecular Medicine 31.6 (2013): 1298-1304.
Chicago
Yang, J., Zhou, Y., Liu, B., Wang, H., Du, X."Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction". International Journal of Molecular Medicine 31, no. 6 (2013): 1298-1304. https://doi.org/10.3892/ijmm.2013.1332
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