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Article

Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways

  • Authors:
    • Chen Zhu
    • Hui Qin
    • Tao Cheng
    • Hong-Lue Tan
    • Yong-Yuan Guo
    • Si-Feng Shi
    • De-Sheng Chen
    • Xian-Long Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, P.R. China, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
  • Pages: 1484-1494
    |
    Published online on: April 15, 2013
       https://doi.org/10.3892/ijmm.2013.1346
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Abstract

Mammalian β-defensins are small cationic peptides of approximately 2-6 kDa that have been implicated in mediating innate immune defenses against microbial infection. Previous studies have reported that mouse β-defensin-14 (MBD‑14), based on structural and functional similarities, appears to be an ortholog of human β-defensin-3 (HBD-3). The aim of this study was to identify the signaling pathways that contribute to the expression of MBD-14 in mouse osteoblasts (OBs) upon contact with methicillin-resistant Staphylococcus aureus (S. aureus) supernatant (SAS) to provide a theoretical basis for the use of MDB-14 as a therapeutic agent in the treatment of intramedullary infection with S. aureus in vivo. The bacterial exoproducts released by S. aureus mainly include a large amount of enterotoxins. Using mouse OBs, the release and regulation of MBD-14 was evaluated by real-time polymerase chain reaction (PCR) and enzyme‑linked immunosorbent assay (ELISA) following exposure to SAS. The activation of the p38 mitogen‑activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) pathways was determined by western blot analysis. OBs treated with lipopolysaccharide (LPS) were used as the positive control. The results revealed that SAS significantly promoted the phosphorylation of p38 MAPK, NF-κB and the inhibitory subunit of NF-κBα (IκBα) in a time-dependent manner. The treatment of OBs with SB203580 (an inhibitor of p38 MAPK) and pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-κB) prior to stimulation with SAS significantly inhibited the phosphorylation and mRNA expression of p38 MAPK and NF-κB p65, simultaneously reducing the release of MBD-14. Our findings suggest that the release of MBD-14 is mediated at least in part through the activation of p38 MAPK and NF-κB in response to S. aureus‑secreted bacterial exoproducts. Moreover, our data demonstrate the innate immune capacity of OBs under conditions of bacterial challenge to enhance the local expression of this MBD-14, a peptide with anti‑staphylococcal activity.
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1 

Montanaro L, Speziale P, Campoccia D, et al: Scenery of Staphylococcus implant infections in orthopedics. Future Microbiol. 6:1329–1349. 2011.PubMed/NCBI

2 

Marriott I, Gray DL, Rati DM, et al: Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. Bone. 37:504–512. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Ning R, Zhang X, Guo X and Li Q: Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis. 15:189–194. 2011. View Article : Google Scholar

4 

Warnke PH, Springer IN, Russo PA, et al: Innate immunity in human bone. Bone. 38:400–408. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Campoccia D, Montanaro L, Speziale P and Arciola CR: Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials. 31:6363–6377. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Shi Z, Neoh KG, Kang ET, Poh C and Wang W: Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions. Tissue Eng Part A. 15:417–426. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kumarasamy KK, Toleman MA, Walsh TR, et al: Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 10:597–602. 2010. View Article : Google Scholar

8 

Zuo GY, An J, Han J, et al: Isojacareubin from the Chinese Herb Hypericum japonicum: potent antibacterial and synergistic effects on clinical methicillin-resistant Staphylococcus aureus (MRSA). Int J Mol Sci. 13:8210–8218. 2012.PubMed/NCBI

9 

Hancock RE: Mechanism of action of newer antibiotics for gram-positive pathogens. Lancet Infect Dis. 5:209–218. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Pazgier M, Hoover DM, Yang D, Lu W and Lubkowski J: Human beta-defensins. Cell Mol Life Sci. 63:1294–1313. 2006. View Article : Google Scholar

11 

Maisetta G, Batoni G, Esin S, Florio W, Bottai D, Favilli F and Campa M: In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob Agents Chemother. 50:806–809. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zhu C, Tan H, Cheng T, et al: Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation. J Surg Res. Dec 20–2012.(Epub ahead of print).

13 

Yamaguchi Y, Nagase T, Makita R, et al: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J Immunol. 169:2516–2523. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Hinrichsen K, Podschun R, Schubert S, Schröder JM, Harder J and Proksch E: Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3. Antimicrob Agents Chemother. 52:1876–1879. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Röhrl J, Yang D, Oppenheim JJ and Hehlgans T: Identification and biological characterization of mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 283:5414–5419. 2008.PubMed/NCBI

16 

Ahrens K, Schunck M, Podda GF, et al: Mechanical and metabolic injury to the skin barrier leads to increased expression of murine β-defensin-1, -3, and -14. J Invest Dermatol. 131:443–452. 2011.PubMed/NCBI

17 

Lee HY, Takeshita T, Shimada J, et al: Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38 MAPK signaling pathway in human middle ear epithelial cells. BMC Infect Dis. 8:872008. View Article : Google Scholar : PubMed/NCBI

18 

Hussain T, Nasreen N, Lai Y, Bellew BF, Antony VB and Mohammed KA: Innate immune responses in murine pleural mesothelial cells: toll-like receptor-2 dependent induction of beta-defensin-2 by staphylococcal peptidoglycan. Am J Physiol Lung Cell Mol Physiol. 295:L461–L470. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Varoga D, Wruck CJ, Tohidnezhad M, et al: Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3. Histochem Cell Biol. 131:207–218. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Die L, Yan P, Jun Jiang Z, Min Hua T, Cai W and Xing L: Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts. Mol Immunol. 52:38–49. 2012.PubMed/NCBI

21 

Nihonyanagi S, Kanoh Y, Okada K, et al: Clinical usefulness of multiplex PCR lateral flow in MRSA detection: a novel, rapid genetic testing method. Inflammation. 35:927–934. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Suzuki A, Guicheux J, Palmer G, et al: Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone. 30:91–98. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Han SH, Kim KH, Han JS, et al: Response of osteoblast-like cells cultured on zirconia to bone morphogenetic protein-2. J Periodontal Implant Sci. 41:227–233. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Gläser R, Harder J, Lange H, Bartels J, Christophers E and Schröder JM: Antimicrobial psoriasin (S100A7) protects human skin from E. coli infection. Nat Immunol. 6:57–64. 2005.PubMed/NCBI

25 

Menzies BE and Kenoyer A: Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun. 74:6847–6854. 2006.PubMed/NCBI

26 

An N, Rausch-fan X, Wieland M, Matejka M, Andrukhov O and Schedle A: Initial attachment, subsequent cell proliferation/viability and gene expression of epithelial cells related to attachment and wound healing in response to different titanium surfaces. Dent Mater. 28:1207–1214. 2012. View Article : Google Scholar

27 

Li JY, Huang JY, Li M, et al: Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro. Acta Pharmacol Sin. 33:935–940. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Tan H, Peng Z, Li Q, Xu X, Guo S and Tang T: The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant Staphylococcus. Biomaterials. 33:365–377. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Bar-Yehuda S, Luger D, Ochaion A, et al: Inhibition of experimental auto-immune uveitis by the A3 adenosine receptor agonist CF101. Int J Mol Med. 28:727–31. 2011.PubMed/NCBI

30 

Jang BC, Lim KJ, Paik JH, et al: Up-regulation of human beta-defensin 2 by interleukin-1 beta in A549 cells: involvement of PI3K, PKC, p38 MAPK, JNK, and NF-kappaB. Biochem Biophys Res Commun. 320:1026–1033. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Shim KS, Kang JS, Lee MH and Ma JY: Selaginella tamariscina water extract inhibits receptor activator for the nuclear factor-κB ligand-induced osteoclast differentiation by blocking mitogen-activated protein kinase and NF-κB signaling. Pharmacogn Mag. 8:184–191. 2012. View Article : Google Scholar

32 

Mineshiba J, Myokai F, Mineshiba F, Matsuura K, Nishimura F and Takashiba S: Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells. FEMS Immunol Med Microbiol. 45:37–44. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Hu DL, Omoe K, Sashinami H, Shinagawa K and Nakane A: Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEAD227A, protects against enterotoxin-induced emesis in house musk shrews. J Infect Dis. 199:302–310. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Rasooly R and Hernlem B: TNF as biomarker for rapid quantification of active Staphylococcus enterotoxin A in food. Sensors (Basel). 12:5978–5985. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Lucke M, Schmidmaier G, Sadoni S, et al: Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats. Bone. 32:521–531. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Semple F, MacPherson H, Webb S, et al: Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol. 41:3291–3300. 2011.

37 

Lai Y and Gallo RL: AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 30:131–141. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Röhrl J, Yang D, Oppenheim JJ and Hehlgans T: Human beta-defensin 2 and 3 and their mouse orthologs induce chemo-taxis through interaction with CCR2. J Immunol. 184:6688–6694. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu C, Qin H, Cheng T, Tan H, Guo Y, Shi S, Chen D and Zhang X: Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways. Int J Mol Med 31: 1484-1494, 2013.
APA
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S. ... Zhang, X. (2013). Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways. International Journal of Molecular Medicine, 31, 1484-1494. https://doi.org/10.3892/ijmm.2013.1346
MLA
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S., Chen, D., Zhang, X."Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways". International Journal of Molecular Medicine 31.6 (2013): 1484-1494.
Chicago
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S., Chen, D., Zhang, X."Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways". International Journal of Molecular Medicine 31, no. 6 (2013): 1484-1494. https://doi.org/10.3892/ijmm.2013.1346
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu C, Qin H, Cheng T, Tan H, Guo Y, Shi S, Chen D and Zhang X: Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways. Int J Mol Med 31: 1484-1494, 2013.
APA
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S. ... Zhang, X. (2013). Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways. International Journal of Molecular Medicine, 31, 1484-1494. https://doi.org/10.3892/ijmm.2013.1346
MLA
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S., Chen, D., Zhang, X."Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways". International Journal of Molecular Medicine 31.6 (2013): 1484-1494.
Chicago
Zhu, C., Qin, H., Cheng, T., Tan, H., Guo, Y., Shi, S., Chen, D., Zhang, X."Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways". International Journal of Molecular Medicine 31, no. 6 (2013): 1484-1494. https://doi.org/10.3892/ijmm.2013.1346
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