Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo

  • Authors:
    • Xin Zeng
    • Ying Cheng
    • Yuejun Qu
    • Jide Xu
    • Zhiyuan Han
    • Tingting Zhang
  • View Affiliations

  • Published online on: June 27, 2013     https://doi.org/10.3892/ijmm.2013.1425
  • Pages: 629-636
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Abstract

The inhibition of the proliferation of airway smooth muscle cells (ASMCs) is crucial for the prevention and treatment of asthma. Recent studies have revealed some important functions of curcumin; however, its effects on the proliferation of ASMCs in asthma remain unknown. Therefore, in this study, we performed in vitro and in vivo experiments to investigate the effects of curcumin on the proliferation of ASMCs in asthma. The thickness of the airway wall, the airway smooth muscle layer, the number of ASMCs and the expression of extracellular signal-regulated kinase (ERK) were significantly reduced in the curcumin-treated group as compared with the model group. Curcumin inhibited the cell proliferation induced by platelet-derived growth factor (PDGF) and decreased the PDGF-induced phosphorylation of ERK1/2 in the rat ASMCs. Moreover, the disruption of caveolae using methyl-β-cyclodextrin (MβCD) attenuated the anti-proliferative effects of curcumin in the ASMCs, which suggests that caveolin is involved in this process. Curcumin upregulated the mRNA and protein expression of caveolin-1. The data presented in this study demonstrate that the proliferation of ASMCs is inhibited by curcumin in vitro and in vivo; curcumin exerts these effects by upregulating the expression of caveolin-1 and blocking the activation of the ERK pathway.
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September 2013
Volume 32 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zeng X, Cheng Y, Qu Y, Xu J, Han Z and Zhang T: Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo. Int J Mol Med 32: 629-636, 2013
APA
Zeng, X., Cheng, Y., Qu, Y., Xu, J., Han, Z., & Zhang, T. (2013). Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo. International Journal of Molecular Medicine, 32, 629-636. https://doi.org/10.3892/ijmm.2013.1425
MLA
Zeng, X., Cheng, Y., Qu, Y., Xu, J., Han, Z., Zhang, T."Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo". International Journal of Molecular Medicine 32.3 (2013): 629-636.
Chicago
Zeng, X., Cheng, Y., Qu, Y., Xu, J., Han, Z., Zhang, T."Curcumin inhibits the proliferation of airway smooth muscle cells in vitro and in vivo". International Journal of Molecular Medicine 32, no. 3 (2013): 629-636. https://doi.org/10.3892/ijmm.2013.1425