Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September 2013 Volume 32 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2013 Volume 32 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation

  • Authors:
    • Qi Li
    • Xiang-Dong Zhou
    • Victor P. Kolosov
    • Juliy M. Perelman
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch, Russian Academy of Medical Sciences, Blagoveschensk 675000, Russia
  • Pages: 637-646
    |
    Published online on: July 5, 2013
       https://doi.org/10.3892/ijmm.2013.1434
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Salidroside is an effective component of the traditional Chinese herb, Rhodiola rosea, that is known to have the ability to protect individuals from cold attacks. In the present study, we investigated the effects of salidroside on respiratory epithelial cells exposed to cold temperatures. We wished to determine whether salidroside exerts any effect on cold-induced mucin (MUC) production and the possible mechanisms involved in this process. We incubated HBE16 cells with salidroside, exposed them to a cold stimulus (18˚C), and assayed the following endpoints: MUC production (the expression of MUC5AC), concentration intracellular of free calcium ([Ca2+]i), the activation of the transient receptor potential melastatin 8 (TRPM8) channel and the cAMP response element-binding protein (CREB). Our results revealed a significant increase in the [Ca2+]i concentration, as well as in TRPM8 and CREB expression in the cold-stimulated cells. MUC5AC expression was also increased. Treatment of the cells with salidroside at concentrations of 50 and 100 µM decreased the [Ca2+]i concentration, with a maximal effect detected in the cells treated with 100 µM salidroside. The expression of TRPM8 and TRPM8 channel conductivity were also repressed by salidroside; salidroside decreased the high levels of CREB activity and phosphorylation observed in the cold‑stimulated cells. Furthermore, we transfected the cold‑stimulated cells with CREB small interfering RNA (siRNA) to analyze TRPM8 gene expression in the absence of CREB activity. The results revealed that the cells treated with either CREB siRNA or salidroside expressed low levels of TRPM8 mRNA and protein. These results indicate that salidroside reduces MUC overproduction induced by cold stimuli and that salidroside exerts its protective effects by inhibiting TRPM8 activation, mainly by decreasing CREB activity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Giesbrecht GG: The respiratory system in a cold environment. Aviat Space Environ Med. 66:890–902. 1995.PubMed/NCBI

2 

Voynow JA and Rubin BK: Mucins, mucus, and sputum. Chest. 135:505–512. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC and Erle DJ: IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production. Am J Respir Cell Mol Biol. 36:244–253. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Zhu L, Lee PK, Lee WM, Zhao Y, Yu D and Chen Y: Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway. Am J Respir Cell Mol Biol. 40:610–619. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Turner J and Jones CE: Regulation of mucin expression in respiratory diseases. Biochem Soc Trans. 37:877–881. 2009. View Article : Google Scholar

6 

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI and Julius D: Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 288:306–313. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Caterina MJ, Rosen TA, Tominaga M, Brake AJ and Julius D: A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 398:436–441. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P and Davis JB: TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 418:186–190. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Güler AD, Lee H, Iida T, Shimizu I, Tominaga M and Caterina M: Heat-evoked activation of the ion channel, TRPV4. J Neurosci. 2:6408–6414. 2002.PubMed/NCBI

10 

McKemy DD, Neuhausser WM and Julius D: Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 416:52–58. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S and Patapoutian A: A TRP channel that senses cold stimuli and menthol. Cell. 108:705–715. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Li MC, Li Q, Yang G, Kolosov VP, Perelman JM and Zhou XD: Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism. J Allergy Clin Immunol. 128:626–634. 2011. View Article : Google Scholar

13 

Li YR, Cao W, Guo J, Miao S, Ding GR, Li KC, Wang J and Guo GZ: Comparative investigations on the protective effects of rhodioside, ciwujianoside-B and astragaloside IV on radiation injuries of the hematopoietic system in mice. Phytother Res. 25:644–653. 2011.PubMed/NCBI

14 

Díaz Lanza AM, Abad Martínez MJ, Fernández Matellano L, Recuero Carretero C, Villaescusa Castillo L, Silván Sen AM and Bermejo Benito P: Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti inflammatory activity. Planta Med. 67:219–223. 2001.

15 

Kelly GS: Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 6:293–302. 2001.

16 

Kucinskaite A, Briedis V and Savickas A: Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine. Medicina (Kaunas). 40:614–619. 2004.(In Lithuanian).

17 

Bavencoffe A, Kondratskyi A, Gkika D, Mauroy B, Shuba Y, Prevarskaya N and Skryma R: Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation. J Biol Chem. 286:9849–9855. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Bidaux G, Roudbaraki M, Merle C, Crépin A, Delcourt P, Slomianny C, Thebault S, Bonnal JL, Benahmed M, Cabon F, Mauroy B and Prevarskaya N: Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr Relat Cancer. 12:367–382. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Sabnis AS, Shadid M, Yost GS and Reilly CA: Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol. 39:466–474. 2008. View Article : Google Scholar : PubMed/NCBI

20 

McCoy DD, Knowlton WM and McKemy DD: Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol. 300:R1278–R1287. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zhang L and Barritt GJ: TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? Endocr Relat Cancer. 13:27–38. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Behrendt HJ, Germann T, Gillen C, Hatt H and Jostock R: Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 141:737–745. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Andersson DA, Chase HW and Bevan S: TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 24:5364–5369. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Tolonen A, Pakonen M, Hohtola A and Jalonen J: Phenylpropanoid glycosides from Rhodiola rosea. Chem Pharm Bull (Tokyo). 51:467–470. 2003. View Article : Google Scholar

25 

Mao GX, Wang Y, Qiu Q, Deng HB, Yuan LG, Li RG, Song DQ, Li YY, Li DD and Wang Z: Salidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative status. Mech Ageing Dev. 131:723–731. 2010. View Article : Google Scholar

26 

Li X, Ye X, Li X, Sun X, Liang Q, Tao L, Kang X and Chen J: Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res. 1382:9–18. 2011.

27 

Zhang L, Yu H, Sun Y, Lin X, Chen B, Tan C, Cao G and Wang Z: Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 564:18–25. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Koskela HO: Cold air-provoked respiratory symptoms: the mechanisms and management. Int J Circumpolar Health. 66:91–100. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Rodway GW and Windsor JS: Airway mucociliary function at high altitude. Wilderness Environ Med. 17:271–275. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Dada LA and Sznajder JI: Mitochondrial Ca2+ and ROS take center stage to orchestrate TNF-α-mediated inflammatory responses. J Clin Invest. 121:1683–1685. 2011.PubMed/NCBI

31 

Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M and Sznajder JI: Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 31:3546–3556. 2011.PubMed/NCBI

32 

Galli GL, Lipnick MS, Shiels HA and Block BA: Temperature effects on Ca2+ cycling in scombrid cardiomyocytes: a phylogenetic comparison. J Exp Biol. 214:1068–1076. 2011.PubMed/NCBI

33 

Cho Y, Jang Y, Yang YD, Lee CH, Lee Y and Oh U: TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium. 48:202–208. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Abe J, Hosokawa H, Sawada Y, Matsumura K and Kobayashi S: Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci Lett. 397:140–144. 2006.

35 

Premkumar LS, Raisinghani M, Pingle SC, Long C and Pimentel F: Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation. J Neurosci. 25:11322–11329. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Daniels RL, Takashima Y and McKemy DD: Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem. 84:1570–1582. 2009.PubMed/NCBI

37 

Rohács T, Lopes CM, Michailidis I and Logothetis DE: PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci. 8:626–634. 2005.

38 

Andersson DA, Nash M and Bevan S: Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci. 27:3347–3355. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R and Prevarskaya N: Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. J Biol Chem. 281:40174–40182. 2006.

40 

Bavencoffe A, Gkika D, Kondratskyi A, Beck B, Borowiec AS, Bidaux G, Busserolles J, Eschalier A, Shuba Y, Skryma R and Prevarskaya N: The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway. J Biol Chem. 285:9410–9419. 2010. View Article : Google Scholar : PubMed/NCBI

41 

De Petrocellis L, Starowicz K, Moriello AS, Vivese M, Orlando P and Di Marzo V: Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. Exp Cell Res. 313:1911–1920. 2007.PubMed/NCBI

42 

Andrisani OM: CREB-mediated transcriptional control. Crit Rev Eukaryot Gene Expr. 9:19–32. 1999.

43 

Johannessen M and Moens U: Multisite phosphorylation of the cAMP response element-binding protein (CREB) by a diversity of protein kinases. Front Biosci. 12:1814–1832. 2007.PubMed/NCBI

44 

Johannessen M, Delghandi MP, Seternes OM, Johansen B and Moens U: Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain. Cell Signal. 16:1187–1199. 2004. View Article : Google Scholar

45 

Shaywitz AJ and Greenberg ME: CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem. 68:821–861. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Zhang L and Barritt GJ: Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res. 64:8365–8373. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Q, Zhou X, Kolosov VP and Perelman JM: Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation. Int J Mol Med 32: 637-646, 2013.
APA
Li, Q., Zhou, X., Kolosov, V.P., & Perelman, J.M. (2013). Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation. International Journal of Molecular Medicine, 32, 637-646. https://doi.org/10.3892/ijmm.2013.1434
MLA
Li, Q., Zhou, X., Kolosov, V. P., Perelman, J. M."Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation". International Journal of Molecular Medicine 32.3 (2013): 637-646.
Chicago
Li, Q., Zhou, X., Kolosov, V. P., Perelman, J. M."Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation". International Journal of Molecular Medicine 32, no. 3 (2013): 637-646. https://doi.org/10.3892/ijmm.2013.1434
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Zhou X, Kolosov VP and Perelman JM: Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation. Int J Mol Med 32: 637-646, 2013.
APA
Li, Q., Zhou, X., Kolosov, V.P., & Perelman, J.M. (2013). Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation. International Journal of Molecular Medicine, 32, 637-646. https://doi.org/10.3892/ijmm.2013.1434
MLA
Li, Q., Zhou, X., Kolosov, V. P., Perelman, J. M."Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation". International Journal of Molecular Medicine 32.3 (2013): 637-646.
Chicago
Li, Q., Zhou, X., Kolosov, V. P., Perelman, J. M."Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation". International Journal of Molecular Medicine 32, no. 3 (2013): 637-646. https://doi.org/10.3892/ijmm.2013.1434
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team