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Review Open Access

Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review)

  • Authors:
    • Aikaterini K. Chalkia
    • Demetrios A. Spandidos
    • Efstathios T. Detorakis
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece, Department of Virology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece
    Copyright: © Chalkia et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 539-543
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    Published online on: July 12, 2013
       https://doi.org/10.3892/ijmm.2013.1438
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Abstract

Pterygium is a potentially vision-threatening fibrovascular lesion originating from the conjunctiva that often extends on the corneal surface. Although it has been extensively studied, its pathogenesis has yet to be fully elucidated. Recent evidence on molecular genetic abnormalities in pterygium suggested neoplastic changes of limbal stem cells potentially associated with exposure to ultraviolet (UV) light. Human papillomavirus (HPV) is an oncogenic virus, associated with squamo-proliferative lesions of the anogenital region, skin and oropharynx. Several studies have shown HPV involvement in the pathogenesis of conjunctival neoplastic lesions, including papilloma and squamous cell carcinoma. The involvement of HPV as a co-factor in the pathogenesis of pterygium, although suggested by several studies using PCR and immunohistochemical techniques, remains controversial. Moreover, a marked variation in the prevalence of HPV in ophthalmic pterygium has been reported by different studies. Ethnic susceptibility and methodological differences in the detection of HPV may account for this variation. Surgical excision, often using sophisticated techniques, is the standard current method of therapy for pterygium. However, recurrences are frequent and recurrent lesions tend to be more aggressive. If indeed HPV is involved in pterygium pathogenesis or recurrence, anti-viral medications or vaccination may be new options in pterygium therapy.
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1 

Detorakis ET and Spandidos DA: Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review). Int J Mol Med. 23:439–447. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Hirst LW: The Treatment of pterygium. Surv Ophthalmol. 48:145–180. 2003. View Article : Google Scholar

3 

Coroneo MT: Pterygium as an early indicator of ultraviolet insolation: a hypothesis. Br J Ophthalmol. 77:734–739. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D and Di Girolamo N: Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathol. 178:817–827. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Detorakis ET, Zaravinos A and Spandidos DA: Growth factor expression in ophthalmic pterygia and normal conjunctiva. Int J Mol Med. 25:513–516. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Di Girolamo N, Wakefield D and Coroneo MT: Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head. Invest Ophthalmol Vis Sci. 41:4142–4149. 2000.PubMed/NCBI

7 

Tsai YY, Chiang CC, Yeh KT, Lee H and Cheng YW: Effect of TIMP-1 and MMP in pterygium invasion. Invest Ophthalmol Vis Sci. 51:3462–3467. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Aspiotis M, Tsanou E, Gorezis S, Ioachim E, Skyrlas A, Stefaniotou M and Malamou-Mitsi V: Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1. Eye (Lond). 21:1095–1101. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Solomon A, Li DQ, Lee SB and Tseng SC: Type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines. Invest Ophthalmol Vis Sci. 41:2154–2163. 2000.PubMed/NCBI

10 

Solomon A, Grueterich M, Li DQ, Meller D, Lee SB and Tseng SC: Overexpression of insulin-like growth factor-binding protein-2 in pterygium body fibroblasts. Invest Ophthalmol Vis Sci. 44:573–580. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Detorakis ET, Sourvinos G, Tsamparlakis J and Spandidos DA: Evaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations. Br J Ophthalmol. 82:1324–1328. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Dushku N, Hatcher SL, Albert DM and Reid TW: P53 expression and relation to human papillomavirus infection in pingueculae, pterygia, and limbal tumors. Arch Ophthalmol. 117:1593–1599. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Soussi T, Dehouche K and Béroud C: P53 website and analysis of P53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. Hum Mutat. 15:105–113. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Freed-Pastor WA and Prives C: Mutant p53: one name, many proteins. Genes Dev. 26:1268–1286. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Detorakis ET, Drakonaki EE and Spandidos DA: Molecular genetic alterations and viral presence in ophthalmic pterygium. Int J Mol Med. 6:35–41. 2000.PubMed/NCBI

16 

Tsai YY, Chang CC, Chiang CC, Yeh KT, Chen PL, Chang CH, Chou MC, Lee H and Cheng YW: HPV infection and p53 inactivation in pterygium. Mol Vis. 15:1092–1097. 2009.PubMed/NCBI

17 

Burk RD, Chen Z and Van Doorslaer K: Human papillomaviruses: genetic basis of carcinogenicity. Public Health Genomics. 12:281–290. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Detorakis ET, Sourvinos G and Spandidos DA: Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium. Cornea. 20:164–167. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Gallagher MJ, Giannoudis A, Herrington CS and Hiscott P: Human papillomavirus in pterygium. Br J Ophthalmol. 85:782–784. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Piras F, Moore PS, Ugalde J, Perra MT, Scarpa A and Sirigu P: Detection of human papillomavirus DNA in pterygia from different geographical regions. Br J Ophthalmol. 87:864–866. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Schellini SA, Hoyama E, Shiratori CA, Sakamoto RH and Candeias JM: Lack of papillomavirus (HPV) in pterygia of a Brazilian sample. Arq Bras Oftalmol. 69:519–521. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Sjö NC, von Buchwald C, Prause JU, Norrild B, Vinding T and Heegaard S: Human papillomavirus and pterygium. Is the virus a risk factor? Br J Ophthalmol. 91:1016–1018. 2007.PubMed/NCBI

23 

Takamura Y, Kubo E, Tsuzuki S and Akagi Y: Detection of human papillomavirus in pterygium and conjunctival papilloma by hybrid capture II and PCR assays. Eye (Lond). 22:1442–1445. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Rodrigues FW, Arruda JT, Silva RE and Moura KK: Polymorphism and human papillomavirus DNA associated with pterygium. Genet Mol Res. 7:1251–1258. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Otlu B, Emre S, Turkcuoglu P, Doganay S and Durmaz R: Investigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissue. Eur J Ophthalmol. 19:175–179. 2009.PubMed/NCBI

26 

Piecyk-Sidor M, Polz-Dacewicz M, Zagórski Z and Zarnowski T: Occurrence of human papillomavirus in pterygia. Acta Ophthalmol. 87:890–895. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Hsiao CH, Lee BH, Ngan KW, Chuang WY, Yeung L, Yeh LK, Tan HY, Hui-Kang D and Lin KK: Presence of human papillomavirus in pterygium in Taiwan. Cornea. 29:123–127. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Spandidos D, Xinarianos G, Ergazaki M, Giannoudis A and Tsamparlakis J: The presence of herpesviruses in pterygium. Int J Oncol. 5:749–752. 1994.PubMed/NCBI

29 

Chen YF, Hsiao CH, Ngan KW, Yeung L, Tan HY, Yang KH, Huang SC and Lin KK: Herpes simplex virus and pterygium in Taiwan. Cornea. 27:311–313. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Karcioglu ZA and Issa TM: Human papilloma virus in neoplastic and non-neoplastic conditions of the external eye. Br J Ophthalmol. 81:595–598. 1997. View Article : Google Scholar : PubMed/NCBI

31 

McDonnell JM, McDonnell PJ and Sun YY: Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia. Invest Ophthalmol Vis Sci. 33:184–189. 1992.PubMed/NCBI

32 

Saegusa M, Takano Y, Hashimura M, Okayasu I and Shiga J: HPV type 16 in conjunctival and junctional papilloma, dysplasia, and squamous cell carcinoma. J Clin Pathol. 48:1106–1110. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Sjö NC, Heegaard S, Prause JU, von Buchwald C and Lindeberg H: Human papillomavirus in conjunctival papilloma. Br J Ophthalmol. 85:785–787. 2001.

34 

Sjö NC, von Buchwald C, Cassonnet P, Norrild B, Prause JU, Vinding T and Heegaard S: Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series. Br J Ophthalmol. 91:1014–1015. 2007.PubMed/NCBI

35 

Kiire CA and Dhillon B: The aetiology and associations of conjunctival intraepithelial neoplasia. Br J Ophthalmol. 90:109–113. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Ateenyi-Agaba C, Franceschi S, Wabwire-Mangen F, Arslan A, Othieno E, Binta-Kahwa J, van Doorn LJ, Kleter B, Quint W and Weiderpass E: Human papillomavirus infection and squamous cell carcinoma of the conjunctiva. Br J Cancer. 102:262–267. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Hirst LW, Axelsen RA and Schwab I: Pterygium and associated ocular surface squamous neoplasia. Arch Ophthalmol. 127:31–32. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Artornsombudh P, Sanpavat A, Tinnungwattana U, Tongkhomsai V, Sansopha L and Tulvatana W: Prevalence and clinicopathologic findings of conjunctival epithelial neoplasia in pterygia. Ophthalmology. 120:1337–1340

39 

Bandyopadhyay R, Nag D, Mondal SK, Gangopadhyay S, Bagchi K and Bhaduri G: Ocular surface disorder in pterygium: role of conjunctival impression cytology. Indian J Pathol Microbiol. 53:692–695. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Abreu AL, Souza RP, Gimenes F and Consolaro ME: A review of methods for detect human Papillomavirus infection. Virol J. 9:2622012. View Article : Google Scholar : PubMed/NCBI

41 

Molijn A, Kleter B, Quint W and van Doorn LJ: Molecular diagnosis of human papillomavirus (HPV) infections. J Clin Virol. 32(Suppl 1): S43–S51. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Leto Md, Santos Júnior GF, Porro AM and Tomimori J: Human papillomavirus infection: etiopathogenesis, molecular biology and clinical manifestations. An Bras Dermatol. 86:306–317. 2011.(In English, Portuguese).

43 

Mackay IM: Real-time PCR in the microbiology laboratory. Clin Microbiol Infect. 10:190–212. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Bustin SA, Benes V, Nolan T and Pfaffl MW: Quantitative real-time RT-PCR - a perspective. J Mol Endocrinol. 34:597–601. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Jensen EC: Real-time reverse transcription polymerase chain reaction to measure mRNA: use, limitations, and presentation of results. Anat Rec (Hoboken). 295:1–3. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Todani A and Melki SA: Pterygium current concepts in pathogenesis and treatment. Int Ophthalmol Clin. 49:21–30. 2009.PubMed/NCBI

47 

Jonasch E and Haluska FG: Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist. 6:34–55. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Vann RR and Karp CL: Perilesional and topical interferon alfa-2b for conjunctival and corneal neoplasia. Ophthalmology. 106:91–97. 1999. View Article : Google Scholar : PubMed/NCBI

49 

Karp CL, Moore JK and Rosa RH Jr: Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b. Ophthalmology. 108:1093–1098. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Schechter BA, Schrier A, Nagler RS, Smith EF and Velasquez GE: Regression of presumed primary conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b. Cornea. 21:6–11. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Schechter BA, Rand WJ, Velazquez GE, Williams WD and Starasoler L: Treatment of conjunctival papillomata with topical interferon Alfa-2b. Am J Ophthalmol. 134:268–270. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Esquenazi S: Treatment of early pterygium recurrence with topical administration of interferon alpha-2b. Can J Ophthalmol. 40:185–187. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chalkia AK, Spandidos DA and Detorakis ET: Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). Int J Mol Med 32: 539-543, 2013.
APA
Chalkia, A.K., Spandidos, D.A., & Detorakis, E.T. (2013). Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). International Journal of Molecular Medicine, 32, 539-543. https://doi.org/10.3892/ijmm.2013.1438
MLA
Chalkia, A. K., Spandidos, D. A., Detorakis, E. T."Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review)". International Journal of Molecular Medicine 32.3 (2013): 539-543.
Chicago
Chalkia, A. K., Spandidos, D. A., Detorakis, E. T."Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review)". International Journal of Molecular Medicine 32, no. 3 (2013): 539-543. https://doi.org/10.3892/ijmm.2013.1438
Copy and paste a formatted citation
x
Spandidos Publications style
Chalkia AK, Spandidos DA and Detorakis ET: Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). Int J Mol Med 32: 539-543, 2013.
APA
Chalkia, A.K., Spandidos, D.A., & Detorakis, E.T. (2013). Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). International Journal of Molecular Medicine, 32, 539-543. https://doi.org/10.3892/ijmm.2013.1438
MLA
Chalkia, A. K., Spandidos, D. A., Detorakis, E. T."Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review)". International Journal of Molecular Medicine 32.3 (2013): 539-543.
Chicago
Chalkia, A. K., Spandidos, D. A., Detorakis, E. T."Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review)". International Journal of Molecular Medicine 32, no. 3 (2013): 539-543. https://doi.org/10.3892/ijmm.2013.1438
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