miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2

  • Authors:
    • Tianzhu Qiu
    • Li Zhou
    • Tongshan Wang
    • Jing Xu
    • Jian Wang
    • Wenjiao Chen
    • Xin Zhou
    • Zebo Huang
    • Wei Zhu
    • Yongqian Shu
    • Ping Liu
  • View Affiliations

  • Published online on: July 12, 2013     https://doi.org/10.3892/ijmm.2013.1439
  • Pages: 593-598
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Abstract

Drug resistance is one of the leading causes of chemotherapy failure in cancer treatment. MicroRNAs (miRNAs or miRs) are short non-coding RNA molecules that post-transcriptionally regulate gene expression and play a critical role in diverse biological processes. In this study, we report that miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin. The expression of miR-503 was decreased in the cisplatin-resistant non-small cell lung cancer cells, A549/CDDP, compared with the parental A549 cells. The overexpression of miR-503 sensitized the A549/CDDP cells to cisplatin, whereas the inhibition of miR-503 in the A549 cells increased resistance to cisplatin. Mechanistically, miR-503 specifically targeted Bcl-2, an anti-apoptotic protein upregulated in the A549/CDDP cells. The ectopic expression of miR-503 reduced the Bcl-2 protein level and sensitized the A549/CDDP cells to cisplatin-induced apoptosis. Taken together, our results suggest that miR-503 regulates cell apoptosis, at least in part by targeting Bcl-2, and thus modulates the resistance of non-small cell lung cancer cells to cisplatin.
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September 2013
Volume 32 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Qiu T, Zhou L, Wang T, Xu J, Wang J, Chen W, Zhou X, Huang Z, Zhu W, Shu Y, Shu Y, et al: miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2. Int J Mol Med 32: 593-598, 2013
APA
Qiu, T., Zhou, L., Wang, T., Xu, J., Wang, J., Chen, W. ... Liu, P. (2013). miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2. International Journal of Molecular Medicine, 32, 593-598. https://doi.org/10.3892/ijmm.2013.1439
MLA
Qiu, T., Zhou, L., Wang, T., Xu, J., Wang, J., Chen, W., Zhou, X., Huang, Z., Zhu, W., Shu, Y., Liu, P."miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2". International Journal of Molecular Medicine 32.3 (2013): 593-598.
Chicago
Qiu, T., Zhou, L., Wang, T., Xu, J., Wang, J., Chen, W., Zhou, X., Huang, Z., Zhu, W., Shu, Y., Liu, P."miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2". International Journal of Molecular Medicine 32, no. 3 (2013): 593-598. https://doi.org/10.3892/ijmm.2013.1439