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International Journal of Molecular Medicine
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Review

Mitochondrial DNA mutations and essential hypertension (Review)

  • Authors:
    • Yu Ding
    • Bohou Xia
    • Jinfang Yu
    • Jianhang Leng
    • Jinyu Huang
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Hangzhou First People's Hospital, Hangzhou, Zhejiang, P.R. China, Department of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China, Department of Cardiology, Xiaoshan First People's Hospital, Hangzhou, Zhejiang, P.R. China, Department of Cardiology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang, P.R. China
  • Pages: 768-774
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    Published online on: July 29, 2013
       https://doi.org/10.3892/ijmm.2013.1459
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Abstract

Essential hypertension (EH) is a frequent, chronic, age-related disorder, which remains a major modifiable risk factor for cardiovascular disease despite important advances in our understanding of its pathophysiology. Previous studies have noted a consistent maternal effect on blood pressure (BP). Consequently, mutations in mitochondrial DNA (mtDNA) have become an additional target of investigations on the missing BP heritability. Among these mutations, mt-transfer RNA (tRNA) is a hot mutational spot for pathogenic mutations associated with EH. Mutant mtDNA aggravates mitochondrial dysfunction, pivotally contributing to the clinical phenotype. Moreover, the damaged mitochondria, due to their inability to provide the high-energy requirements for cells, generate reactive oxygen species (ROS) and induce mitochondrial-mediated cell death pathways. Therefore, mitochondrial dysfunction plays a critical role in the pathogenesis of EH. This review summarizes the basic knowledge of mitochondrial genetics and EH-associated mtDNA mutations and further discusses the molecular mechanisms behind these mtDNA mutations in clinical manifestations of EH.
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Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Xia B, Yu J, Leng J and Huang J: Mitochondrial DNA mutations and essential hypertension (Review). Int J Mol Med 32: 768-774, 2013.
APA
Ding, Y., Xia, B., Yu, J., Leng, J., & Huang, J. (2013). Mitochondrial DNA mutations and essential hypertension (Review). International Journal of Molecular Medicine, 32, 768-774. https://doi.org/10.3892/ijmm.2013.1459
MLA
Ding, Y., Xia, B., Yu, J., Leng, J., Huang, J."Mitochondrial DNA mutations and essential hypertension (Review)". International Journal of Molecular Medicine 32.4 (2013): 768-774.
Chicago
Ding, Y., Xia, B., Yu, J., Leng, J., Huang, J."Mitochondrial DNA mutations and essential hypertension (Review)". International Journal of Molecular Medicine 32, no. 4 (2013): 768-774. https://doi.org/10.3892/ijmm.2013.1459
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Xia B, Yu J, Leng J and Huang J: Mitochondrial DNA mutations and essential hypertension (Review). Int J Mol Med 32: 768-774, 2013.
APA
Ding, Y., Xia, B., Yu, J., Leng, J., & Huang, J. (2013). Mitochondrial DNA mutations and essential hypertension (Review). International Journal of Molecular Medicine, 32, 768-774. https://doi.org/10.3892/ijmm.2013.1459
MLA
Ding, Y., Xia, B., Yu, J., Leng, J., Huang, J."Mitochondrial DNA mutations and essential hypertension (Review)". International Journal of Molecular Medicine 32.4 (2013): 768-774.
Chicago
Ding, Y., Xia, B., Yu, J., Leng, J., Huang, J."Mitochondrial DNA mutations and essential hypertension (Review)". International Journal of Molecular Medicine 32, no. 4 (2013): 768-774. https://doi.org/10.3892/ijmm.2013.1459
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