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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2013 Volume 32 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

The Kiss‑1/Kiss‑1R complex as a negative regulator of cell motility and cancer metastasis (Review)

Ke Ji, Lin Ye, Malcolm D. Mason, Wen G. Jiang
Pages: 747-754
Published online on: 21 August 2013

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Review

The role of human endogenous retroviral long terminal repeat sequences in human cancer (Review)

Hong-Lian Yu, Zhan-Kui Zhao, Fan Zhu
Pages: 755-762
Published online on: 30 July 2013

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Review Open Access

Therapeutics targeting angiogenesis: Genetics and epigenetics, extracellular miRNAs and signaling networks (Review)

Masaru Katoh
Pages: 763-767
Published online on: 16 July 2013

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Review

Mitochondrial DNA mutations and essential hypertension (Review)

Yu Ding, Bohou Xia, Jinfang Yu, Jianhang Leng, Jinyu Huang
Pages: 768-774
Published online on: 29 July 2013

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Article Open Access

Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression

Nu Ry Song, Mun Kyung Hwang, Yong-Seok Heo, Ki Won Lee, Hyong Joo Lee
Pages: 775-784
Published online on: 18 July 2013

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Article Open Access

Association between idiopathic hearing loss and mitochondrial DNA mutations: A study on 169 hearing-impaired subjects

Valeria Guaran, Laura Astolfi, Alessandro Castiglione, Edi Simoni, Elena Olivetto, Marco Galasso, Patrizia Trevisi, Micol Busi, Stefano Volinia, Alessandro Martini
Pages: 785-794
Published online on: 16 August 2013

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Article Open Access

High glucose activates the alternative ACE2/Ang‑(1‑7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β‑cells

Carmen Härdtner, Caroline Mörke, Reinhard Walther, Carmen Wolke, Uwe Lendeckel
Pages: 795-804
Published online on: 14 August 2013

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Article

Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells

Wengang Yang, Hui Zheng, Yongyi Wang, Feng Lian, Zhenglei Hu, Song Xue
Pages: 805-812
Published online on: 16 July 2013

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Article

Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets

Yasunari Kageyama, Tomoaki Doi, Shigeru Akamatsu, Gen Kuroyanagi, Akira Kondo, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Shinji Ogura
Pages: 813-818
Published online on: 23 July 2013

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Article

Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway

Tao Bai, Dao-Song Dong, Ling Pei
Pages: 819-826
Published online on: 06 August 2013

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Article

A novel PITX2c loss‑of‑function mutation underlies lone atrial fibrillation

Yi‑Meng Zhou, Peng‑Xiang Zheng, Yi‑Qing Yang, Zhi‑Ming Ge, Wei‑Qiang Kang
Pages: 827-834
Published online on: 02 August 2013

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Article

Transcriptome analysis of murine thymic epithelial cells reveals age‑associated changes in microRNA expression

Zhibin Guo, Feng Chi, Yan Song, Changshan Wang, Ruoxing Yu, Tianli Wei, Jingang Gui, Xike Zhu
Pages: 835-842
Published online on: 21 August 2013

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Article

Bovine apolipoprotein (apo)A-I displays more enhanced antioxidant and anti-atherosclerotic activity in lipid-free and lipid-bound states than human and porcine apoA-I

Seong-Min Kim, Ga-Young Park, Inho Choi, Kyung-Hyun Cho
Pages: 843-850
Published online on: 22 August 2013

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Article

Ghrelin attenuates intestinal ischemia/reperfusion injury in mice by activating the mTOR signaling pathway

Hongwei Zhang, Zhongyi Cui, Guangwei Luo, Jiaheng Zhang, Tao Ma, Na Hu, Tianpen Cui
Pages: 851-859
Published online on: 19 July 2013

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Article

The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma

Young-Joo Jeon, Seon Mi Ko, Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shim
Pages: 860-866
Published online on: 18 July 2013

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Article

Survivin, a key component of the Wnt/β‑catenin signaling pathway, contributes to traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus

Lin Zhang, Rong Yan, Qi Zhang, Haining Wang, Xiaokui Kang, Jia Li, Shuyuan Yang, Jianning Zhang, Zhenlin Liu, Xinyu Yang
Pages: 867-875
Published online on: 24 July 2013

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Article

Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-κB nuclear translocation and the activation of the PI3K/Akt signaling pathway

Shin Hwa Lee, Jun Hyuk Lee, Eun Young Oh, Gi-Young Kim, Byung Tae Choi, Cheolmin Kim, Yung Hyun Choi
Pages: 876-882
Published online on: 16 July 2013

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Article

Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease

Qing Zhao, Dingfang Cai, Yu Bai
Pages: 883-891
Published online on: 18 July 2013

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Article

Liraglutide ameliorates glycometabolism and insulin resistance through the upregulation of GLUT4 in diabetic KKAy mice

Li-Na Chen, Juan Lyu, Xue-Fei Yang, Wen-Jun Ji, Bing-Xiang Yuan, Ming-Xia Chen, Xin Ma, Bing Wang
Pages: 892-900
Published online on: 19 July 2013

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Article

Development of a dendritic cell vaccine encoding multiple cytotoxic T lymphocyte epitopes targeting hepatitis C virus

Yun Zhou, Futao Zhao, Lin Chen, Li Ma, Yu Wang, Yu He, Zhiyuan Ma, Haili Liu, Yonghong Guo, Ying Zhang, Zhiqiang Yao, Chunqiu Hao, Zhansheng Jia
Pages: 901-909
Published online on: 07 August 2013

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Article

Decoy receptor 3 regulates the expression of various genes in rheumatoid arthritis synovial fibroblasts

Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Masayasu Takahashi, Shinya Hayashi, Masahiro Kurosaka
Pages: 910-916
Published online on: 01 August 2013

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Article

Exogenous hydrogen sulfide protects H9c2 cardiac cells against high glucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1/2 pathways

Wenming Xu, Wen Wu, Jingfu Chen, Runmin Guo, Jiancong Lin, Xinxue Liao, Jianqiang Feng
Pages: 917-925
Published online on: 01 August 2013

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Article

Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis through the inhibition of the TLR4/NF‑κB pathway

Xiao Ke, Fan Zhou, Youliang Gao, Bingying Xie, Guanghong Hu, Wenyi Fang, Jun Peng, Youqin Chen, Thomas J. Sferra
Pages: 926-930
Published online on: 29 July 2013

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Article

HIF-1α-induced β-catenin activation prevents prion-mediated neurotoxicity

Jae-Kyo Jeong, Sang-Youel Park
Pages: 931-937
Published online on: 26 July 2013

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Article

Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization

Endy Widya Putranto, Hitoshi Murata, Ken‑Ichi Yamamoto, Ken Kataoka, Hidenori Yamada, Jun‑Ichiro Futami, Masakiyo Sakaguchi, Nam‑Ho Huh
Pages: 938-944
Published online on: 09 August 2013

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Article

Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB

Hui-Hun Kim, Duk-Sil Kim, Sung-Wan Kim, Se-Hyun Lim, Dae Keun Kim, Tae-Yong Shin, Sang-Hyun Kim
Pages: 945-951
Published online on: 07 August 2013

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Article

Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes

Fazli Subhan, Tae-Deuk Yoon, Hee Jung Choi, Ikram Muhammad, Jieun Lee, Changwan Hong, Sae-Ock Oh, Sun-Yong Baek, Bong-Seon Kim, Sik Yoon
Pages: 952-958
Published online on: 18 July 2013

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Article

Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells

Yunjuan Zhang, Lawrence Owusu, Wei Duan, Tao Jiang, Shizhu Zang, Ayaz Ahmed, Yi Xin
Pages: 959-964
Published online on: 16 July 2013

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Article

A method for the ultrastructural preservation of tiny percutaneous needle biopsy material from skeletal muscle

Tiziana Pietrangelo, Stefano Perni, Guglielmo Di Tano, Giorgio Fanò-Illic, Clara Franzini-Armstrong
Pages: 965-970
Published online on: 23 July 2013

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Article

Kaempferol inhibits IL‑1β‑induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX‑2, PGE2 and MMPs

Ha‑Yong Yoon, Eun‑Gyeong Lee, Hyun Lee, In Jin Cho, Yun Jung Choi, Myung‑Soon Sung, Han‑Gyul Yoo, Wan‑Hee Yoo
Pages: 971-977
Published online on: 09 August 2013

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Article Open Access

Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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Review Open Access

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Article Open Access

Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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Article Open Access

ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Review Open Access

Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Review Open Access

Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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Review Open Access

The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Review Open Access

Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Review Open Access

Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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Article Open Access

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Review Open Access

Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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Review Open Access

m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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Article Open Access

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Review Open Access

Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Review Open Access

Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Review Open Access

Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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Article Open Access

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Article Open Access

Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Article Open Access

Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Review Open Access

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Review Open Access

Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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Review Open Access

CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Review Open Access

Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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Review Open Access

The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Review Open Access

Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

Li-Hua Guo, Yu Cao, Run-Tao Zhuang, Yan Han, Jun Li
Article Number: 106
Published online on: 02 March 2026

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June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Yanming Wei, Kun Zhou, Yuerui Su, Zhihua Luan, Pengcheng Li, Yinxia Chang, Bo Han, Huifang Li, Yuanbiao Qiao, Jinhong Ren
Article Number: 142
Published online on: 26 March 2026

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Article Open Access

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
Article Number: 141
Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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