|
1
|
Aw D, Silva AB, Maddick M, et al:
Architectural changes in the thymus of aging mice. Aging Cell.
7:158–167. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Aw D and Palmer DB: The origin and
implication of thymic involution. Aging Dis. 2:437–443.
2011.PubMed/NCBI
|
|
3
|
Naylor K, Li G, Vallejo A N, et al: The
influence of age on T cell generation and TCR diversity. J Immunol.
174:7446–7452. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Maue AC, Yager EJ, Swain SL, et al: T-cell
immunosenescence: lessons learned from mouse models of aging.
Trends Immunol. 30:301–305. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Dorshkind K and Swain S: Age-associated
declines in immune system development and function: causes,
consequences, and reversal. Curr Opin Immunol. 21:404–407. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Foster AD, Sivarapatna A and Gress RE: The
aging immune system and its relationship with cancer. Aging health.
7:707–718. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Gui J, Zhu X, Dohkan J, et al: The aged
thymus shows normal recruitment of lymphohematopoietic progenitors
but has defects in thymic epithelial cells. Int Immunol.
19:1201–1211. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhu X, Gui J, Dohkan J, et al:
Lymphohematopoietic progenitors do not have a synchronized defect
with age-related thymic involution. Aging Cell. 6:663–672. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Gui J, Mustachio LM, Su DM and Craig RW:
Thymus size and age-related thymic involution: early programming,
sexual dimorphism, progenitors and stroma. Aging Dis. 3:280–290.
2012.PubMed/NCBI
|
|
10
|
Gui J, Morales AJ, Maxey SE, et al: MCL1
increases primitive thymocyte viability in female mice and promotes
thymic expansion into adulthood. Int Immunol. 23:647–659. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Bravo-Nuevo A, O’Donnell R, Rosendahl A,
et al: RhoB deficiency in thymic medullary epithelium leads to
early thymic atrophy. Int Immunol. 23:593–600. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Ortman CL, Dittmar KA, Witte PL and Le PT:
Molecular characterization of the mouse involuted thymus:
aberrations in expression of transcription regulators in thymocyte
and epithelial compartments. Int Immunol. 14:813–822. 2002.
View Article : Google Scholar
|
|
13
|
Lustig A, Carter A, Bertak D, et al:
Transcriptome analysis of murine thymocytes reveals age-associated
changes in thymic gene expression. Int J Med Sci. 6:51–64. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Sun L, Guo J, Brown R, et al: Declining
expression of a single epithelial cell-autonomous gene accelerates
age-related thymic involution. Aging Cell. 9:347–357. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kvell K, Varecza Z, Bartis D, et al: Wnt4
and LAP2alpha as pacemakers of thymic epithelial senescence. PLoS
One. 5:e107012010. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Weatherall DJ: Thalassaemia: the long road
from bedside to genome. Nat Rev Genet. 5:625–631. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Esquela-Kerscher A and Slack FJ: Oncomirs
- microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006.
View Article : Google Scholar
|
|
18
|
Zhao Y, Ransom JF, Li A, et al:
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle
in mice lacking miRNA-1-2. Cell. 129:303–317. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Mencia A, Modamio-Høybjør S, Redshaw N, et
al: Mutations in the seed region of human miR-96 are responsible
for nonsyndromic progressive hearing loss. Nat Genet. 41:609–613.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
20
|
Feng J, Sun G, Yan J, et al: Evidence for
X-chromosomal schizophrenia associated with microRNA alterations.
PLoS One. 4:e61212009. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Muljo SA, Ansel KM, Kanellopoulou C, et
al: Aberrant T cell differentiation in the absence of Dicer. J Exp
Med. 202:261–269. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Li QJ, Chau J, Ebert PJ, et al: miR-181a
is an intrinsic modulator of T cell sensitivity and selection.
Cell. 129:147–161. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chen CZ, Li L, Lodish HF and Bartel DP:
MicroRNAs modulate hematopoietic lineage differentiation. Science.
303:83–86. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Rodriguez A, Vigorito E, Clare S, et al:
Requirement of bic/microRNA-155 for normal immune function.
Science. 316:608–611. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Neilson JR, Zheng GX, Burge CB and Sharp
PA: Dynamic regulation of miRNA expression in ordered stages of
cellular development. Genes Dev. 21:578–589. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Virts EL and Thoman ML: Age-associated
changes in miRNA expression profiles in thymopoiesis. Mech Ageing
Dev. 131:743–748. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chen LH, Chiou GY, Chen YW, et al:
MicroRNA and aging: a novel modulator in regulating the aging
network. Ageing Res Rev. 9(Suppl 1): S59–S66. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Noren Hooten N, Abdelmohsen K, Gorospe M,
et al: microRNA expression patterns reveal differential expression
of target genes with age. PLoS One. 5:e107242010.PubMed/NCBI
|
|
29
|
O’Connell RM, Rao DS, Chaudhuri AA, et al:
Sustained expression of microRNA-155 in hematopoietic stem cells
causes a myeloproliferative disorder. J Exp Med. 205:585–594.
2008.PubMed/NCBI
|
|
30
|
Ventura A, Young AG, Winslow MM, et al:
Targeted deletion reveals essential and overlapping functions of
the miR-17 through 92 family of miRNA clusters. Cell. 132:875–886.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Xiao C, Srinivasan L, Calado DP, et al:
Lymphoproliferative disease and autoimmunity in mice with increased
miR-17-92 expression in lymphocytes. Nat Immunol. 9:405–414. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Sheiness D and Gardinier M: Expression of
a proto-oncogene (proto-myb) in hemopoietic tissues of mice. Mol
Cell Biol. 4:1206–1212. 1984.PubMed/NCBI
|
|
33
|
Schulz C, Gomez Perdiguero E, Chorro L, et
al: A lineage of myeloid cells independent of Myb and hematopoietic
stem cells. Science. 336:86–90. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Shukla A and Yuspa SH: CLIC4 and
Schnurri-2: A dynamic duo in TGF-beta signaling with broader
implications in cellular homeostasis and disease. Nucleus.
1:144–149. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Shukla A, Malik M, Cataisson C, et al:
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear
translocation of CLIC4 and consequent stabilization of
phospho-Smad2 and 3. Nat Cell Biol. 11:777–784. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Staton TL, Lazarevic V, Jones DC, et al:
Dampening of death pathways by schnurri-2 is essential for T-cell
development. Nature. 472:105–109. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Nakayama T and Kimura MY: Memory Th1/Th2
cell generation controlled by Schnurri-2. Adv Exp Med Biol.
684:1–10. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kimura MY, Iwamura C, Suzuki A, et al:
Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J
Immunol. 178:4926–4936. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Tu SW, Bugde A, Luby-Phelps K and Cobb MH:
WNK1 is required for mitosis and abscission. Proc Natl Acad Sci
USA. 108:1385–1390. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Jiang ZY, Zhou QL, Holik J, et al:
Identification of WNK1 as a substrate of Akt/protein kinase B and a
negative regulator of insulin-stimulated mitogenesis in 3T3-L1
cells. J Biol Chem. 280:21622–21628. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Sun X, Gao L, Yu RK and Zeng G:
Down-regulation of WNK1 protein kinase in neural progenitor cells
suppresses cell proliferation and migration. J Neurochem.
99:1114–1121. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lee BH, Chen W, Stippec S and Cobb MH:
Biological cross-talk between WNK1 and the transforming growth
factor beta-Smad signaling pathway. J Biol Chem. 282:17985–17996.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Gottipati S, Rao NL and Fung-Leung WP:
IRAK1: a critical signaling mediator of innate immunity. Cell
Signal. 20:269–276. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
An H, Hou J, Zhou J, et al: Phosphatase
SHP-1 promotes TLR- and RIG-I-activated production of type I
interferon by inhibiting the kinase IRAK1. Nat Immunol. 9:542–550.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Jacob CO, Zhu J, Armstrong DL, et al:
Identification of IRAK1 as a risk gene with critical role in the
pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci
USA. 106:6256–6261. 2009. View Article : Google Scholar : PubMed/NCBI
|
