Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November 2013 Volume 32 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2013 Volume 32 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation

  • Authors:
    • Monowar Aziz
    • Shunji Ishihara
    • Mesbah Uddin Ansary
    • Hiroki Sonoyama
    • Yasumasa Tada
    • Akihiko Oka
    • Ryusaku Kusunoki
    • Yuji Tamagawa
    • Nobuhiko Fukuba
    • Yoshiyuki Mishima
    • Tsuyoshi Mishiro
    • Naoki Oshima
    • Ichiro Moriyama
    • Norihisa Ishimura
    • Shuichi Sato
    • Takafumi Yuki
    • Kousaku Kawashima
    • Yoshikazu Kinoshita
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine II, Shimane University School of Medicine, Shimane 693-8051, Japan, Department of Gastrointestinal Endoscopy, Shimane University Hospital, Shimane 690-8504, Japan
  • Pages: 1051-1062
    |
    Published online on: September 18, 2013
       https://doi.org/10.3892/ijmm.2013.1501
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

During intestinal inflammation, a variety of signaling events are activated to perform several cell functions. Although the distinct roles of these pathways have been elucidated, the effects of their crosstalk activities remain to be clarified. We evaluated the crosstalk between two evolutionary conserved cell signaling systems, toll-like-receptor (TLR) 5 and Notch1, in intestinal epithelial cells during inflammation. Significant induction of the expression of Notch1 and Jagged1 was observed in the distal part of the colon, together with abundant localization of Notch1 intracellular domain (N1ICD) in the surface epithelium of inflamed colonic mucosa. By targeting intestinal epithelial cells, it was shown that recombination-signal-binding-protein-Jκ (RBP-Jκ)-mediated Notch functions are dependent on a flagellin-TLR5-mediated pathway. Conversely, using a γ-secretase inhibitor, we demonstrated that Notch synergistically increases TLR5‑mediated NF-κB activation. In addition, the effects of Notch on the NF-κB target gene interleukin-6 (IL-6) expression were revealed by evaluating the RBP-Jκ responsive element in the IL-6 promoter in vitro. Modulation of TLR5 and Notch crosstalk by transient blocking of Notch during the acute phase of colitis was beneficial for ameliorating colonic inflammation as well as disease status. In conclusion, the results suggest the effectiveness of Notch-targeted drug strategy for the treatment of intestinal inflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ishihara S, Aziz MM, Yuki T, Kazumori H and Kinoshita Y: Inflammatory bowel disease: review from the aspect of genetics. J Gastroenterol. 44:1097–1108. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Mizoguchi A and Mizoguchi E: Inflammatory bowel disease: past, present, and future: lessons from animal models. J Gastroenterol. 43:1–17. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Xavier RJ and Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature. 448:427–434. 2007. View Article : Google Scholar

4 

Medzhitov R, Preston-Hurlburt P and Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394–397. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Ortega-Cava CF, Ishihara S, Rumi MA, et al: Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol. 170:3977–3985. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Uematsu S and Akira S: Immune responses of TLR5(+) lamina propira dendritic cells in enterobacterial infection. J Gastroenterol. 44:803–811. 2009.

7 

Ishihara S, Rumi MA, Kadowaki Y, et al: Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol. 173:1406–416. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Vijay-Kumar M, Sanders CJ, Taylor RT, et al: Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest. 117:3909–3921. 2007.PubMed/NCBI

9 

Cario E: Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword. Inflamm Bowel Dis. 14:411–421. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Gribar SC, Anand RJ, Sodhi CP and Hackam DJ: The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation. J Leukoc Biol. 83:493–498. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T and Watanabe M: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 296:G23–G35. 2009. View Article : Google Scholar

12 

Kuhnert F, Davis CR, Wang HT, et al: Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA. 101:266–271. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Lees CW, Zacharias WJ, Tremelling M, et al: Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med. 5:e2392008. View Article : Google Scholar : PubMed/NCBI

14 

Artavanis-Tsakonas S, Matsuno K and Fortini ME: Notch signaling. Science. 268:225–232. 1995. View Article : Google Scholar

15 

Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: cell fate control and signal integration in development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Krebs LT, Xue Y, Norton CR, et al: Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 14:1343–1352. 2000.PubMed/NCBI

17 

Fung E, Tang SM, Canner JP, et al: Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation. 115:2948–2956. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Bedogni B, Warneke JA, Nickoloff BJ, et al: Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest. 118:3660–3670. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Schroder N and Gossler A: Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns. 2:247–250. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Katoh M and Katoh M: Notch signaling in gastrointestinal tract (Review). Int J Oncol. 30:247–251. 2007.PubMed/NCBI

21 

Nakamura T, Tsuchiya K and Watanabe M: Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol. 42:705–710. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Ishizuya-Oka A and Hasebe T: Sonic hedgehog and bone morphogenetic protein-4 signaling pathway involved in epithelial cell renewal along the radial axis of the intestine. Digestion. 77:42–47. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG and Edgar BA: Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell. 137:1343–1355. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Fre S, Pallavi SK, Huyghe M, et al: Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci USA. 106:6309–6314. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Oshima N, Ishihara S, Rumi MA, et al: A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol. 159:185–198. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Rhee SH, Im E, Riegler M, Kokkotou E, O’Brien M and Pothoulakis C: Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci USA. 102:13610–13615. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Aziz MM, Ishihara S, Rumi MA, et al: Prolactin induces MFG-E8 production in macrophages via transcription factor C/EBPbeta-dependent pathway. Apoptosis. 13:609–620. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Gewirtz AT, Navas TA, Lyons S, Godowski PJ and Madara JL: Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol. 167:1882–1885. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Solt LA and May MJ: The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res. 42:3–18. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Verma UN, Yamamoto Y, Prajapati S and Gaynor RB: Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J Biol Chem. 279:3509–3515. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Rudolph D, Yeh WC, Wakeham B, et al: Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev. 14:854–862. 2000.PubMed/NCBI

32 

Shifera AS, Friedman JM and Horwitz MS: IKK gamma (NEMO) is involved in the coordination of the AP-1 and NF-kappa B pathways. Mol Cell Biochem. 310:181–190. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Vales LD and Friedl EM: Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression. J Biol Chem. 277:42438–42446. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Moriyama I, Ishihara S, Rumi MA, et al: Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis. Lab Invest. 88:652–663. 2008. View Article : Google Scholar

35 

Aziz MM, Ishihara S, Mishima Y, et al: MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling. J Immunol. 182:7222–7232. 2009. View Article : Google Scholar

36 

van Es JH and Clevers H: Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med. 11:496–502. 2005.PubMed/NCBI

37 

Radtke F, Schweisguth F and Pear W: The Notch ‘gospel’. EMBO Rep. 6:1120–1125. 2005.

38 

Hurlbut GD, Kankel MW, Lake RJ and Artavanis-Tsakonas S: Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol. 19:166–175. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH and Osborne BA: Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur J Immunol. 38:174–183. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Shin HM, Minter LM, Cho OH, et al: Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J. 25:129–138. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Osipo C, Golde TE, Osborne BA and Miele LA: Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab Invest. 88:11–17. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Cheng P, Zlobin A, Volgina V, et al: Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol. 167:4458–4467. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Amsen D, Antov A and Flavell RA: The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol. 9:116–124. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Abreu MT, Fukata M and Arditi M: TLR signaling in the gut in health and disease. J Immunol. 174:4453–4460. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Aziz M, Ishihara S, Ansary MU, Sonoyama H, Tada Y, Oka A, Kusunoki R, Tamagawa Y, Fukuba N, Mishima Y, Mishima Y, et al: Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation. Int J Mol Med 32: 1051-1062, 2013.
APA
Aziz, M., Ishihara, S., Ansary, M.U., Sonoyama, H., Tada, Y., Oka, A. ... Kinoshita, Y. (2013). Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation. International Journal of Molecular Medicine, 32, 1051-1062. https://doi.org/10.3892/ijmm.2013.1501
MLA
Aziz, M., Ishihara, S., Ansary, M. U., Sonoyama, H., Tada, Y., Oka, A., Kusunoki, R., Tamagawa, Y., Fukuba, N., Mishima, Y., Mishiro, T., Oshima, N., Moriyama, I., Ishimura, N., Sato, S., Yuki, T., Kawashima, K., Kinoshita, Y."Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation". International Journal of Molecular Medicine 32.5 (2013): 1051-1062.
Chicago
Aziz, M., Ishihara, S., Ansary, M. U., Sonoyama, H., Tada, Y., Oka, A., Kusunoki, R., Tamagawa, Y., Fukuba, N., Mishima, Y., Mishiro, T., Oshima, N., Moriyama, I., Ishimura, N., Sato, S., Yuki, T., Kawashima, K., Kinoshita, Y."Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation". International Journal of Molecular Medicine 32, no. 5 (2013): 1051-1062. https://doi.org/10.3892/ijmm.2013.1501
Copy and paste a formatted citation
x
Spandidos Publications style
Aziz M, Ishihara S, Ansary MU, Sonoyama H, Tada Y, Oka A, Kusunoki R, Tamagawa Y, Fukuba N, Mishima Y, Mishima Y, et al: Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation. Int J Mol Med 32: 1051-1062, 2013.
APA
Aziz, M., Ishihara, S., Ansary, M.U., Sonoyama, H., Tada, Y., Oka, A. ... Kinoshita, Y. (2013). Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation. International Journal of Molecular Medicine, 32, 1051-1062. https://doi.org/10.3892/ijmm.2013.1501
MLA
Aziz, M., Ishihara, S., Ansary, M. U., Sonoyama, H., Tada, Y., Oka, A., Kusunoki, R., Tamagawa, Y., Fukuba, N., Mishima, Y., Mishiro, T., Oshima, N., Moriyama, I., Ishimura, N., Sato, S., Yuki, T., Kawashima, K., Kinoshita, Y."Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation". International Journal of Molecular Medicine 32.5 (2013): 1051-1062.
Chicago
Aziz, M., Ishihara, S., Ansary, M. U., Sonoyama, H., Tada, Y., Oka, A., Kusunoki, R., Tamagawa, Y., Fukuba, N., Mishima, Y., Mishiro, T., Oshima, N., Moriyama, I., Ishimura, N., Sato, S., Yuki, T., Kawashima, K., Kinoshita, Y."Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation". International Journal of Molecular Medicine 32, no. 5 (2013): 1051-1062. https://doi.org/10.3892/ijmm.2013.1501
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team