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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2013 Volume 32 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1

Ruth Amann, Beat Trueb
Pages: 983-988
Published online on: 10 September 2013

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Article

Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study

Ryuichiro Sakata, Toru Nakamura, Takuji Torimura, Takato Ueno, Michio Sata
Pages: 989-994
Published online on: 20 September 2013

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Article

Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke

Asimina Lazaridou, Loukas Astrakas, Dionyssios Mintzopoulos, Azadeh Khanicheh, Aneesh B. Singhal, Michael A. Moskowitz, Bruce Rosen, Aria A. Tzika
Pages: 995-1000
Published online on: 27 August 2013

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Article

Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis

Guangwen Wu, Wenlie Chen, Huailing Fan, Chunsong Zheng, Jianfeng Chu, Ruhui Lin, Jinxia Ye, Huifeng Xu, Xihai Li, Yunmei  Huang, Hongzhi Ye, Xianxiang Liu, Mingxia Wu
Pages: 1001-1010
Published online on: 04 September 2013

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Article

Cardioprotective effects of exenatide against oxidative stress-induced injury

Guanglei Chang, Dongying Zhang, Hui Yu, Peng Zhang, Ying Wang, Aihua Zheng, Shu Qin
Pages: 1011-1020
Published online on: 27 August 2013

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Article

Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS

Fang Xie, Jiu-Cong Zhang, Han Fu, Jun Chen
Pages: 1021-1028
Published online on: 11 September 2013

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Article

The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed rats

Lu-Ping Ren, Guang-Yao Song, Zhi-Juan Hu, Mingming Zhang, Lanbo Peng, Shu-Chun Chen, Limin Wei, Fan Li, Wen Sun
Pages: 1029-1036
Published online on: 12 September 2013

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Article

Selective inhibition of PKCβ2 preserves cardiac function after myocardial infarction and is associated with improved angiogenesis of ischemic myocardium in diabetic rats

Fabin Wang, Dong Huang, Wei Zhu, Shuai Li, Meiling Yan, Meng Wei, Jingbo Li
Pages: 1037-1046
Published online on: 28 August 2013

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Article

A new method for the quantification of aortic calcification by three-dimensional micro-computed tomography

C. Huesa, J. L. Millán, R. J. van 't Hof, V. E. MacRae
Pages: 1047-1050
Published online on: 12 September 2013

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Article

Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation

Monowar Aziz, Shunji Ishihara, Mesbah Uddin Ansary, Hiroki Sonoyama, Yasumasa Tada, Akihiko Oka, Ryusaku Kusunoki, Yuji Tamagawa, Nobuhiko Fukuba, Yoshiyuki Mishima, Tsuyoshi Mishiro, Naoki Oshima, Ichiro Moriyama, Norihisa Ishimura, Shuichi Sato, Takafumi Yuki, Kousaku Kawashima, Yoshikazu Kinoshita
Pages: 1051-1062
Published online on: 18 September 2013

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Article

Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genes in vivo

Shan Ren, Yongjun Liu, Jinfeng Ma, Yong Liu, Zezheng Diao, Deling Yang, Xu Zhang, Yongming Xi, Yougu Hu
Pages: 1063-1068
Published online on: 17 September 2013

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Article

Tongue coating microbiome regulates the changes in tongue texture and coating in patients with post-menopausal osteoporosis of Gan-shen deficiency syndrome type

Wenna Liang, Xihai Li, Yachan Li, Candong Li, Bizheng Gao, Huijuan Gan, Sumin Li, Jianying Shen, Jie Kang, Shanshan Ding, Xuejuan Lin, Linghong Liao
Pages: 1069-1076
Published online on: 10 September 2013

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Article

Saponin B, a novel cytostatic compound purified from Anemone taipaiensis, induces apoptosis in a human glioblastoma cell line

Yuangang Wang, Haifeng Tang, Yun Zhang, Juan Li, Bo Li, Zhenhui Gao, Xiaoyang Wang, Guang Cheng, Zhou Fei
Pages: 1077-1084
Published online on: 18 September 2013

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Article

Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi

Haitao Liu, Feng Hou, Haiying Liang, Guocheng Liu, Yunfei Li
Pages: 1085-1092
Published online on: 12 September 2013

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Article

High interstitial fluid pressure promotes tumor cell proliferation and invasion in oral squamous cell carcinoma

Tao Yu, Kun Liu, Yingying Wu, Jinchuan Fan, Jianchao Chen, Chao Li, Guiquan Zhu, Zhaohui Wang, Longjiang Li
Pages: 1093-1100
Published online on: 13 September 2013

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Article

Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions

Wei-Feng Pi, Xue-Jun Guo, Li-Ping Su, Wei-Guo Xu
Pages: 1101-1109
Published online on: 11 September 2013

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Article

Establishment of a transgenic mouse model of corneal dystrophy overexpressing human BIGH3

Xin Liao, Hongping Cui, Fang Wang
Pages: 1110-1114
Published online on: 04 September 2013

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Article

Analysis of microRNA expression profile by small RNA sequencing in Down syndrome fetuses

Yong Xu, Wuxian Li, Xueyan Liu, Hualin Ma, Zhiguang Tu, Yong Dai
Pages: 1115-1125
Published online on: 18 September 2013

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Article

Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin‑dependent pathway

Hae Jin Rhee, Liting Ji, Seung‑Hyuk Kim, Jongho Lee
Pages: 1126-1136
Published online on: 12 September 2013

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Article

The O‑glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo

Arash Minai‑Tehrani, Seung‑Hee Chang, Seung Bum Park, Myung‑Haing Cho
Pages: 1137-1149
Published online on: 05 September 2013

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Article

High-glucose-based peritoneal dialysis solution induces the upregulation of VEGF expression in human peritoneal mesothelial cells: The role of pleiotrophin

Jia Liu, Xia Wu, Yanchun Liu, Yaguang Xu, Yuhan Huang, Changying Xing, Xiaoyun Wang
Pages: 1150-1158
Published online on: 12 September 2013

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Article

Aquaporin-9 downregulation prevents steatosis in oleic acid-induced non-alcoholic fatty liver disease cell models

Chuan Wang, Zi-Lan Lv, Yu-Jun Kang, Ting-Xiu Xiang, Pi-Long Wang, Zheng Jiang
Pages: 1159-1165
Published online on: 19 September 2013

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Article

Novel mutation in exon 56 of the dystrophin gene in a child with Duchenne muscular dystrophy

Jian-Fang Zhu, Hui-Hui Liu, Tao Zhou, Li Tian
Pages: 1166-1170
Published online on: 18 September 2013

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Article

Purpurogallin exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated BV2 microglial cells through the inactivation of the NF‑κB and MAPK signaling pathways

Hye Young Park, Tae Hoon Kim, Chan Gil Kim, Gi‑Young Kim, Cheol Min Kim, Nam Deuk Kim, Byung Woo Kim, Hye Jin Hwang, Yung Hyun Choi
Pages: 1171-1178
Published online on: 30 August 2013

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Article

α-lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet

Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhang
Pages: 1179-1186
Published online on: 05 September 2013

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Article

Novel function of the poly(c)-binding protein α-CP2 as a transcriptional activator that binds to single-stranded DNA sequences

Duk-Hee Kang, Kyu Young Song, Li-Na Wei, Ping-Yee Law, Horace H. Loh, Hack Sun Choi
Pages: 1187-1194
Published online on: 11 September 2013

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Article

Association between CAG repeat polymorphisms and the risk of prostate cancer: A meta-analysis by race, study design and the number of (CAG)n repeat polymorphisms

Jun-Hyun Sun, Sang-Ah Lee
Pages: 1195-1203
Published online on: 23 August 2013

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Article

Whole genome expression profiling and screening for differentially expressed cytokine genes in human bone marrow endothelial cells treated with humoral inhibitors in liver cirrhosis

Bo Gao, Wang Sun, Xianqi Wang, Xu Jia, Biao Ma, Yu Chang, Weihui Zhang, Dongbo Xue
Pages: 1204-1214
Published online on: 13 September 2013

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Article

Knockdown of mTOR by lentivirus‑mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E‑deficient mice

Xiaochuang Wang, Lingxia Li, Manxiang Li, Xiaoyan Dang, Lin Wan, Ni Wang, Xiaoju Bi, Changwei Gu, Suijuan Qiu, Xiaolin Niu, Xinye Zhu, Lina Wang
Pages: 1215-1221
Published online on: 12 September 2013

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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Review Open Access

GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Review Open Access

Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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