Vitamin D binding protein plays an important role in the progression of endometriosis

  • Authors:
    • Jin-Hee Hwang
    • Tao Wang
    • Kyu-Sup Lee
    • Jong-Kil Joo
    • Hong-Gu Lee
  • View Affiliations

  • Published online on: September 24, 2013     https://doi.org/10.3892/ijmm.2013.1506
  • Pages: 1394-1400
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Abstract

Endometriosis, characterized by the growth of the endometrial gland and stroma outside the uterine cavity, is a gynecological disorder affecting 6‑10% of women of reproductive age. However, the pathogenesis of endometriosis and the molecular mechanisms involved in the progression of this disease remain to be clarified. Therefore, in this study two-dimensional gel electrophoresis (2‑DE) combined with mass spectrometry (MS) were applied to explore endometrial proteins with a role in the progression of endometriosis. Expression of global proteins in ectopic endometrial tissue (n=13; endometriosis group) was compared with that of the normal endometrial tissue (n=6; control group). Sixteen differently expressed proteins, including Vitamin D binding protein (DBP), with various functions were primarily identified in the ectopic endometrial tissue. DBP was confirmed to be significantly increased in the ectopic endometrial tissue compared with that in the normal endometrial tissue (P<0.05). Results of the present study therefore showed that DBP may play an important role in the progression of endometriosis.
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December 2013
Volume 32 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hwang J, Wang T, Lee K, Joo J and Lee H: Vitamin D binding protein plays an important role in the progression of endometriosis. Int J Mol Med 32: 1394-1400, 2013
APA
Hwang, J., Wang, T., Lee, K., Joo, J., & Lee, H. (2013). Vitamin D binding protein plays an important role in the progression of endometriosis. International Journal of Molecular Medicine, 32, 1394-1400. https://doi.org/10.3892/ijmm.2013.1506
MLA
Hwang, J., Wang, T., Lee, K., Joo, J., Lee, H."Vitamin D binding protein plays an important role in the progression of endometriosis". International Journal of Molecular Medicine 32.6 (2013): 1394-1400.
Chicago
Hwang, J., Wang, T., Lee, K., Joo, J., Lee, H."Vitamin D binding protein plays an important role in the progression of endometriosis". International Journal of Molecular Medicine 32, no. 6 (2013): 1394-1400. https://doi.org/10.3892/ijmm.2013.1506