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Article

Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia

  • Authors:
    • Yu Ri Kim
    • Ha Neui Kim
    • Ji Yeon Jang
    • Cheol Park
    • Jun Hyuk Lee
    • Hwa Kyoung Shin
    • Yung Hyun Choi
    • Byung Tae Choi
  • View Affiliations / Copyright

    Affiliations: Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan 626-870, Republic of Korea, Department of Biochemistry, College of Oriental Medicine, Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan 614-052, Republic of Korea, Chemistry and Biotechnology Examination Bureau, Korean Intellectual Property Office, Daejeon 302-701, Republic of Korea
  • Pages: 1303-1310
    |
    Published online on: September 27, 2013
       https://doi.org/10.3892/ijmm.2013.1511
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Abstract

In this study, we investigated the molecular mechanisms underlying the anti-apoptotic properties of electroacupuncture (EA) in a rat model of middle cerebral artery occlusion (MCAO). Treatment with 2 Hz EA (1 mA) resulted in a markedly reduced infarct area after stroke, particularly in the middle region of the brain. Treatment with EA resulted in a significant decrease in the number of apoptotic cells identified by Hoechst 33342 and TUNEL staining. According to the results of the analysis for proteins involved in apoptosis, treatment with EA resulted in a significantly reduced expression of death receptor (DR)5. Among the members of the Bcl‑2 family, a higher expression of anti-apoptotic Bcl‑2 and Bcl‑xL was observed in the rats treated with EA, compared with the untreated rats with MCAO. As regards the expression of the inhibitor of apoptosis protein (IAP) family, a higher expression of anti-apoptotic cIAP‑1 and ‑2 was also detected in the cortex of the EA‑treated rats. Using western blot analysis, we observed that activated caspase‑3 was only significantly arrested by EA treatment in the rats with MCAO; however, according to the results of the caspase assay, the activities of caspase‑3, ‑8 and ‑9 were markedly inhibited by EA treatment. These results suggest that treatment with EA exerts anti‑apoptotic effects in cerebral ischemia in a rat model of MCAO and that these effects are associated with the inhibition of the DR and mitochondrial apoptotic pathways.
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1 

Shichita T, Hasegawa E, Kimura A, et al: Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med. 18:911–917. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Lansberg MG, Bluhmki E and Thijs VN: Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. Stroke. 40:2438–2441. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Li X, Luo P, Wang Q and Xiong L: Electroacupuncture pretreatment as a novel avenue to protect brain against ischemia and reperfusion injury. Evid Based Complement Alternat Med. 2012:1953972012.PubMed/NCBI

4 

Nakka VP, Gusain A, Mehta SL and Raghubir R: Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol. 37:7–38. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Ginsberg MD: The new language of cerebral ischemia. AJNR Am J Neuroradiol. 18:1435–1445. 1997.PubMed/NCBI

6 

Love S: Apoptosis and brain ischaemia. Prog Neuropsychopharmacol Biol Psychiatry. 27:267–282. 2003. View Article : Google Scholar

7 

Kato H and Kogure K: Biochemical and molecular characteristics of the brain with developing cerebral infarction. Cell Mol Neurobiol. 19:93–108. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257. 1972. View Article : Google Scholar : PubMed/NCBI

9 

Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:623–634. 1988. View Article : Google Scholar : PubMed/NCBI

10 

Lee JM, Zipfel GJ and Choi DW: The changing landscape of ischaemic brain injury mechanisms. Nature. 399:A7–A14. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Krajewski S, Krajewska M, Ellerby LM, et al: Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci USA. 96:5752–5757. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Lam TT, Abler AS and Tso MO: Apoptosis and caspases after ischemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci. 40:967–975. 1999.PubMed/NCBI

13 

Xiong ZQ and McNamara JO: Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. Neuron. 36:363–374. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Neumar RW, Hagle SM, DeGracia DJ, Krause GS and White BC: Brain mu-calpain autolysis during global cerebral ischemia. J Neurochem. 66:421–424. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Namura S, Zhu J, Fink K, et al: Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci. 18:3659–3668. 1998.PubMed/NCBI

16 

Broughton BR, Reutens DC and Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke. 40:e331–e339. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Campbell MT, Dagher P, Hile KL, et al: Tumor necrosis factor-alpha induces intrinsic apoptotic signaling during renal obstruction through truncated bid activation. J Urol. 180:2694–2700. 2008. View Article : Google Scholar

18 

Wang SJ, Omori N, Li F, et al: Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats. Neurosci Lett. 331:115–118. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Du Y, Shi L, Li J, Xiong J, Li B and Fan X: Angiogenesis and improved cerebral blood flow in the ischemic boundary area were detected after electroacupuncture treatment to rats with ischemic stroke. Neurol Res. 33:101–107. 2011. View Article : Google Scholar

20 

Wang Q, Li X, Chen Y, et al: Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1. Stroke. 42:389–396. 2011. View Article : Google Scholar

21 

Sze FK, Wong E, Yi X and Woo J: Does acupuncture have additional value to standard poststroke motor rehabilitation? Stroke. 33:186–194. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Fang Z, Ning J, Xiong C and Shulin Y: Effects of electroacupuncture at head points on the function of cerebral motor areas in stroke patients: a PET study. Evid Based Complement Alternat Med. 2012:9024132012. View Article : Google Scholar : PubMed/NCBI

23 

Foley LM, Hitchens TK, Barbe B, et al: Quantitative temporal profiles of penumbra and infarction during permanent middle cerebral artery occlusion in rats. Transl Stroke Res. 1:220–229. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479–489. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Cui M, Wang L, Liang X, et al: Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiol Dis. 39:138–147. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Velier JJ, Ellison JA, Kikly KK, Spera PA, Barone FC and Feuerstein GZ: Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat. J Neurosci. 19:5932–5941. 1999.PubMed/NCBI

27 

Krupinski J, Lopez E, Marti E and Ferrer I: Expression of caspases and their substrates in the rat model of focal cerebral ischemia. Neurobiol Dis. 7:332–342. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:491–501. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:481–490. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS and Duckett CS: Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem. 279:51082–51090. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Eckelman BP, Salvesen GS and Scott FL: Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 7:988–994. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Rothe M, Pan MG, Henzel WJ, Ayres TM and Goeddel DV: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 83:1243–1252. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD and Gores GJ: Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Exp Cell Res. 317:107–116. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Sugawara T, Fujimura M, Morita-Fujimura Y, Kawase M and Chan PH: Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci. 19:RC391999.

35 

Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 68:383–424. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Yuan J and Yankner BA: Apoptosis in the nervous system. Nature. 407:802–809. 2000. View Article : Google Scholar

37 

Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609–619. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Sedlak TW, Oltvai ZN, Yang E, et al: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA. 92:7834–7838. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Kuida K, Haydar TF, Kuan CY, et al: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 94:325–337. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Noshita N, Sugawara T, Fujimura M, Morita-Fujimura Y and Chan PH: Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 21:557–567. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Shehadah A, Chen J, Zacharek A, et al: Niaspan treatment induces neuroprotection after stroke. Neurobiol Dis. 40:277–283. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM and Chen CS: The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem. 275:11397–11403. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Rau TF, Kothiwal A, Zhang L, et al: Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway. Neuropharmacology. 61:677–686. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Kim YR, Kim HN, Jang JY, et al: Electroacupuncture confers beneficial effects through ionotropic glutamate receptors involving phosphatidylinositol-3 kinase/Akt signaling pathway in focal cerebral ischemia in rats. Eur J Integr Med. 4:e413–420. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kim YR, Kim HN, Jang JY, Park C, Lee JH, Shin HK, Choi YH and Choi BT: Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia. Int J Mol Med 32: 1303-1310, 2013.
APA
Kim, Y.R., Kim, H.N., Jang, J.Y., Park, C., Lee, J.H., Shin, H.K. ... Choi, B.T. (2013). Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia. International Journal of Molecular Medicine, 32, 1303-1310. https://doi.org/10.3892/ijmm.2013.1511
MLA
Kim, Y. R., Kim, H. N., Jang, J. Y., Park, C., Lee, J. H., Shin, H. K., Choi, Y. H., Choi, B. T."Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia". International Journal of Molecular Medicine 32.6 (2013): 1303-1310.
Chicago
Kim, Y. R., Kim, H. N., Jang, J. Y., Park, C., Lee, J. H., Shin, H. K., Choi, Y. H., Choi, B. T."Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia". International Journal of Molecular Medicine 32, no. 6 (2013): 1303-1310. https://doi.org/10.3892/ijmm.2013.1511
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YR, Kim HN, Jang JY, Park C, Lee JH, Shin HK, Choi YH and Choi BT: Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia. Int J Mol Med 32: 1303-1310, 2013.
APA
Kim, Y.R., Kim, H.N., Jang, J.Y., Park, C., Lee, J.H., Shin, H.K. ... Choi, B.T. (2013). Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia. International Journal of Molecular Medicine, 32, 1303-1310. https://doi.org/10.3892/ijmm.2013.1511
MLA
Kim, Y. R., Kim, H. N., Jang, J. Y., Park, C., Lee, J. H., Shin, H. K., Choi, Y. H., Choi, B. T."Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia". International Journal of Molecular Medicine 32.6 (2013): 1303-1310.
Chicago
Kim, Y. R., Kim, H. N., Jang, J. Y., Park, C., Lee, J. H., Shin, H. K., Choi, Y. H., Choi, B. T."Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia". International Journal of Molecular Medicine 32, no. 6 (2013): 1303-1310. https://doi.org/10.3892/ijmm.2013.1511
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