The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

Chang,Jun; Wang,Wei; Zhang,Hui; Hu,Yong; Wang,Mingli; Yin,Zongsheng

doi:10.3892/ijmm.2013.1520

The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

Authors:
- Jun Chang
- Wei Wang
- Hui Zhang
- Yong Hu
- Mingli Wang
- Zongsheng Yin
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Affiliations: Department of Orthopaedics, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Microbiology, Anhui Medical University, Hefei, Anhui 230022, P.R. China
Published online on: October 11, 2013 https://doi.org/10.3892/ijmm.2013.1520
Pages: 1311-1318

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Abstract

The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that the expression of autophagy-related proteins was not decreased in the tissues of patients with OA. We also observed that rapamycin-induced autophagy prevented the accumulation of subdiploid cells in young chondrocytes, while it induced cell death by autophagy in OA chondrocytes. Our results demonstrate that autophagic activity decreases with aging, and may be responsible for the cytoprotective effects in young cartilage. However, we found that autophagic activity in patients with OA was higher than in the aging group, and reported autophagic cell death in OA chondrocytes. These results suggest that autophagy plays both a cytoprotective and death-promoting role in the pathogenesis of OA.

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