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December 2013 Volume 32 Issue 6

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Article

The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

  • Authors:
    • Jun Chang
    • Wei Wang
    • Hui Zhang
    • Yong Hu
    • Mingli Wang
    • Zongsheng Yin
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Microbiology, Anhui Medical University, Hefei, Anhui 230022, P.R. China
  • Pages: 1311-1318
    |
    Published online on: October 11, 2013
       https://doi.org/10.3892/ijmm.2013.1520
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Abstract

The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that the expression of autophagy-related proteins was not decreased in the tissues of patients with OA. We also observed that rapamycin-induced autophagy prevented the accumulation of subdiploid cells in young chondrocytes, while it induced cell death by autophagy in OA chondrocytes. Our results demonstrate that autophagic activity decreases with aging, and may be responsible for the cytoprotective effects in young cartilage. However, we found that autophagic activity in patients with OA was higher than in the aging group, and reported autophagic cell death in OA chondrocytes. These results suggest that autophagy plays both a cytoprotective and death-promoting role in the pathogenesis of OA.
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Copy and paste a formatted citation
Spandidos Publications style
Chang J, Wang W, Zhang H, Hu Y, Wang M and Yin Z: The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis. Int J Mol Med 32: 1311-1318, 2013.
APA
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., & Yin, Z. (2013). The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis. International Journal of Molecular Medicine, 32, 1311-1318. https://doi.org/10.3892/ijmm.2013.1520
MLA
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., Yin, Z."The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis". International Journal of Molecular Medicine 32.6 (2013): 1311-1318.
Chicago
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., Yin, Z."The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis". International Journal of Molecular Medicine 32, no. 6 (2013): 1311-1318. https://doi.org/10.3892/ijmm.2013.1520
Copy and paste a formatted citation
x
Spandidos Publications style
Chang J, Wang W, Zhang H, Hu Y, Wang M and Yin Z: The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis. Int J Mol Med 32: 1311-1318, 2013.
APA
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., & Yin, Z. (2013). The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis. International Journal of Molecular Medicine, 32, 1311-1318. https://doi.org/10.3892/ijmm.2013.1520
MLA
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., Yin, Z."The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis". International Journal of Molecular Medicine 32.6 (2013): 1311-1318.
Chicago
Chang, J., Wang, W., Zhang, H., Hu, Y., Wang, M., Yin, Z."The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis". International Journal of Molecular Medicine 32, no. 6 (2013): 1311-1318. https://doi.org/10.3892/ijmm.2013.1520
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