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Review

The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)

  • Authors:
    • Yu-Xin Liao
    • Cheng-Hao Zhou
    • Hui Zeng
    • Dong-Qing Zuo
    • Zhuo‑Ying Wang
    • Fei Yin
    • Ying-Qing Hua
    • Zheng-Dong Cai
  • View Affiliations / Copyright

    Affiliations: Shanghai Bone Cancer Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 1239-1246
    |
    Published online on: October 11, 2013
       https://doi.org/10.3892/ijmm.2013.1521
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Abstract

Bone sarcomas, which comprise less than 1% of all human malignancies, are a group of relatively rare mesenchymal-derived tumors. They are mainly composed of osteosarcoma, chondrosarcoma and Ewing's sarcoma. In spite of advances in adjuvant chemotherapy and wide surgical resection, prognosis remains poor due to the high propensity for lung metastasis, which is the leading cause of mortality in patients with bone sarcomas. Chemokines are a superfamily of small pro-inflammatory chemoattractant cytokines which can bind to specific G protein-coupled seven-span transmembrane receptors. Chemokine 12 (CXCL12), also designated as stromal cell-derived factor-1 (SDF-1), is able to bind to its cognate receptors, chemokine receptor 4 (CXCR4) and chemokine receptor 7 (CXCR7), with high affinity. The binding of CXCL12 to CXCR4/CXCR7 stimulates the activation of several downstream signaling pathways that regulate tumor progression and metastasis. In this review, the structure and function of CXCL12 and its receptors, CXCR4 and CXCR7, as well as many factors affecting their expression are discussed. Phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways are the two most important downstream pathways regulated by the CXCL12-CXCR4/CXCR7 interaction. CXCR4 expression in bone sarcomas, including tumor cells and samples and the correlation between CXCR4/CXCR7 expression and the survival of patients with bone sarcomas are also discussed. In addition, we review the involvement of the CXCL12‑CXCR4/CXCR7 axis in the growth and metastasis of bone sarcomas and the targeting of this axis in preclinical studies.
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Copy and paste a formatted citation
Spandidos Publications style
Liao Y, Zhou C, Zeng H, Zuo D, Wang ZY, Yin F, Hua Y and Cai Z: The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review). Int J Mol Med 32: 1239-1246, 2013.
APA
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F. ... Cai, Z. (2013). The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review). International Journal of Molecular Medicine, 32, 1239-1246. https://doi.org/10.3892/ijmm.2013.1521
MLA
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F., Hua, Y., Cai, Z."The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)". International Journal of Molecular Medicine 32.6 (2013): 1239-1246.
Chicago
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F., Hua, Y., Cai, Z."The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)". International Journal of Molecular Medicine 32, no. 6 (2013): 1239-1246. https://doi.org/10.3892/ijmm.2013.1521
Copy and paste a formatted citation
x
Spandidos Publications style
Liao Y, Zhou C, Zeng H, Zuo D, Wang ZY, Yin F, Hua Y and Cai Z: The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review). Int J Mol Med 32: 1239-1246, 2013.
APA
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F. ... Cai, Z. (2013). The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review). International Journal of Molecular Medicine, 32, 1239-1246. https://doi.org/10.3892/ijmm.2013.1521
MLA
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F., Hua, Y., Cai, Z."The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)". International Journal of Molecular Medicine 32.6 (2013): 1239-1246.
Chicago
Liao, Y., Zhou, C., Zeng, H., Zuo, D., Wang, Z., Yin, F., Hua, Y., Cai, Z."The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)". International Journal of Molecular Medicine 32, no. 6 (2013): 1239-1246. https://doi.org/10.3892/ijmm.2013.1521
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