cMET as a potential therapeutic target in gastric cancer (Review)

  • Authors:
    • Lisong Teng
    • Jun Lu
  • View Affiliations

  • Published online on: October 18, 2013     https://doi.org/10.3892/ijmm.2013.1531
  • Pages: 1247-1254
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Abstract

Gastric cancer is one of the most common malignancies worldwide. Despite improvements in surgery and chemotherapy, the outcomes in patients with advanced gastric cancer remain poor. cMET is a member of the receptor tyrosine kinase family, and plays a key role in tumor survival, growth, angiogenesis and metastasis. cMET overexpression and/or gene amplification occurs in a significant proportion of gastric cancers. cMET is associated with a high tumor stage and poor prognosis. Several cMET inhibitors have been investigated in clinical trials, and the initial results are encouraging. It has become increasingly apparent that cMET is a promising therapeutic target in gastric cancer. In this review, we summarize the development of cMET inhibitors in the preclinical and clinical environment. In addition, we discuss the challenges of cMET-targeted therapy in gastric cancer and explore possible solutions.
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December 2013
Volume 32 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Teng L and Teng L: cMET as a potential therapeutic target in gastric cancer (Review). Int J Mol Med 32: 1247-1254, 2013
APA
Teng, L., & Teng, L. (2013). cMET as a potential therapeutic target in gastric cancer (Review). International Journal of Molecular Medicine, 32, 1247-1254. https://doi.org/10.3892/ijmm.2013.1531
MLA
Teng, L., Lu, J."cMET as a potential therapeutic target in gastric cancer (Review)". International Journal of Molecular Medicine 32.6 (2013): 1247-1254.
Chicago
Teng, L., Lu, J."cMET as a potential therapeutic target in gastric cancer (Review)". International Journal of Molecular Medicine 32, no. 6 (2013): 1247-1254. https://doi.org/10.3892/ijmm.2013.1531