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2014-January Volume 33 Issue 1

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Article

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

  • Authors:
    • Hui Li
    • Xue Yang
    • Wei Shi
    • Zhao Ma
    • Guangshen Feng
    • Qinzhou Wang
    • Li Shen
    • Chunli Xie
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China, Department of Neurology, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China, Department of Gynecotokology, Jinan Central Hospital, Jinan, Shandong, P.R. China, Department of Emergency, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China, Clinical Laboratory, Jinan Fourth People's Hospital, Jinan, Shandong, P.R. China
  • Pages: 201-208
    |
    Published online on: October 30, 2013
       https://doi.org/10.3892/ijmm.2013.1540
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Abstract

In the present study, we used chronic gavage administration of alcohol with gradual increases in alcohol concentration and volume to generate a rat model of chronic alcohol intoxication. We measured the changes in biological, behavioral, pathological and vascular injury-related molecular biological markers, and explored the effects of nimodipine intervention on alcohol intoxication. We found that chronic alcohol consumption induced a variety of behavioral abnormalities, accompanied by severe pathological changes in cerebral arterioles, prefrontal cortex and cerebellar tissue, as well as an upregulation of vascular endothelial growth factor (VEGF), leptin receptor (ob-R) and endothelin-1 (ET-1). Treatment with mimodipine for 15 days significantly improved behavioral abnormalities, alleviated the pathological changes in blood vessels and brain tissues, increased VEGF expression, decreased ob-R expression, reduced plasma ET-1 leakage and protected vascular and neuronal functions.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Yang X, Shi W, Ma Z, Feng G, Wang Q, Shen L and Xie C: Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. Int J Mol Med 33: 201-208, 2014.
APA
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q. ... Xie, C. (2014). Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. International Journal of Molecular Medicine, 33, 201-208. https://doi.org/10.3892/ijmm.2013.1540
MLA
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q., Shen, L., Xie, C."Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy". International Journal of Molecular Medicine 33.1 (2014): 201-208.
Chicago
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q., Shen, L., Xie, C."Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy". International Journal of Molecular Medicine 33, no. 1 (2014): 201-208. https://doi.org/10.3892/ijmm.2013.1540
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Yang X, Shi W, Ma Z, Feng G, Wang Q, Shen L and Xie C: Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. Int J Mol Med 33: 201-208, 2014.
APA
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q. ... Xie, C. (2014). Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. International Journal of Molecular Medicine, 33, 201-208. https://doi.org/10.3892/ijmm.2013.1540
MLA
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q., Shen, L., Xie, C."Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy". International Journal of Molecular Medicine 33.1 (2014): 201-208.
Chicago
Li, H., Yang, X., Shi, W., Ma, Z., Feng, G., Wang, Q., Shen, L., Xie, C."Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy". International Journal of Molecular Medicine 33, no. 1 (2014): 201-208. https://doi.org/10.3892/ijmm.2013.1540
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