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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
2014-January Volume 33 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Complex interaction between the immune system and adipose tissue (Review)

Sylwia Małgorzewicz, Jolanta Anna Dardzińska, Maria Gnacińska, Jerzy Jankun, Ewa Bryl, Krzysztof Sworczak
Pages: 3-7
Published online on: 25 October 2013

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Article Open Access

Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells

Marjaneh Motaghed, Faisal Muti Al-Hassan, Shahrul Sahul Hamid
Pages: 8-16
Published online on: 21 November 2013

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Article Open Access

DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells

Kan Chen, Qiuwei Pan, Ying Gao, Xinyan Yang, Shibing Wang, Maikel P. Peppelenbosch, Xiangdong Kong
Pages: 17-24
Published online on: 30 October 2013

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Article Open Access

Integrated profiling of microRNA expression in membranous nephropathy using high-throughput sequencing technology

Wenbiao Chen, Xiaocong Lin, Jianrong Huang, Kuibi Tan, Yuyu Chen, Wujian Peng, Wuxian Li, Yong Dai
Pages: 25-34
Published online on: 12 November 2013

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Article Open Access

Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin

Stephanie S. Wang, Ruth Hsiao, Mariko M. Limpar, Sarah Lomahan, Tuan-Anh Tran, Nolan J. Maloney, Naohiko Ikegaki, Xao X. Tang
Pages: 35-42
Published online on: 01 November 2013

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Article Open Access

Characterization of microRNA expression profiles in patients with intervertebral disc degeneration

Bo Zhao, Qiang Yu, Haopeng Li, Xiong Guo, Xijing He
Pages: 43-50
Published online on: 30 October 2013

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Article Open Access

Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein

Fang Liu, Chao Wang, Lijun Zhang, Yuqiao Xu, Lina Jang, Yu Gu, Xiangmei Cao, Xin Zhao, Jing Ye, Qing Li
Pages: 51-58
Published online on: 19 November 2013

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Article Open Access

Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis

Xiao-Yan Shi, Lin Gu, Jie Chen, Xi-Rong Guo, Ying-Li Shi
Pages: 59-67
Published online on: 25 October 2013

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Article

Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats

Shiho Arima, Hirofumi Uto, Rie Ibusuki, Ryo Kumamoto, Shirou Tanoue, Seiichi Mawatari, Kohei Oda, Masatsugu Numata, Hiroshi Fujita, Makoto Oketani, Akio Ido, Hirohito Tsubouchi
Pages: 68-76
Published online on: 01 November 2013

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Article

Detection of mitochondrial DNA mutations by high-throughput sequencing in the blood of breast cancer patients

Lin Hai Li, Tao Kang, Lidan Chen, Weiyun Zhang, Yang Liao, Jianyun Chen, Yuling Shi
Pages: 77-82
Published online on: 19 November 2013

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Article

The pathophysiological mechanisms underlying mucus hypersecretion induced by cold temperatures in cigarette smoke-exposed rats

Min-Chao Li, Gang Yang, Xiang-Dong Zhou, Sergey Tselluyko, Juliy M. Perelman
Pages: 83-90
Published online on: 23 October 2013

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Article

Cancer-associated fibroblasts enhance the migration ability of ovarian cancer cells by increasing EZH2 expression

Linjuan Xu, Qingchun Deng, Yinglian Pan, Minggang Peng, Xiaoling Wang, Limian Song, Man Xiao, Zehua Wang
Pages: 91-96
Published online on: 07 November 2013

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Article

C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis through the phosphoinositide 3-kinase/Akt pathway

Meng Hou, Jingjin Liu, Fang Liu, Kai Liu, Bo Yu
Pages: 97-104
Published online on: 07 November 2013

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Article

The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension

Xue Zhang, Zong-Shuai Wang, Yun Luan, Mei Lin, Xiao-Bo Zhu, Yu Ma, Zhao-Hua Zhang, Yi-Biao Wang
Pages: 105-110
Published online on: 21 November 2013

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Article

Neuroglobin as a regulator of mitochondrial-dependent apoptosis: A bioinformatics analysis

Diego Guidolin, Luigi F. Agnati, Cinzia Tortorella, Manuela Marcoli, Guido Maura, Giovanna Albertin, Kjell Fuxe
Pages: 111-116
Published online on: 21 November 2013

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Article

Treatment of liver cancer in mice by the intratumoral injection of an octreotide-based temperature‑sensitive gel

Lili Zhang, Su Yu, Zhijun Duan, Qiuming Wang, Ge Tian, Yan Tian, Wei Zhao, Hui Wang, Cuiling Zhang, Shibin Guo, Qigui Liu, Gaohong He, Tengfei Bian, Jiuyang Chang, Xue Jin, Dongsheng Cui
Pages: 117-127
Published online on: 30 October 2013

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Article

Effects of mulberry ethanol extracts on hydrogen peroxide-induced oxidative stress in pancreatic β-cells

Young Rae Kim, Jong Seok Lee, Ki Rim Lee, Young Eon Kim, Nam In Baek, Eock Kee Hong
Pages: 128-134
Published online on: 23 October 2013

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Article

The effect of activin A on signal transduction pathways in PC12 cells subjected to oxygen and glucose deprivation

Hongliang Guo, Xiaoran Shen, Ye Xu, Youdi He, Wenli Hu
Pages: 135-141
Published online on: 30 October 2013

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Article

Inhibition of IL-32 and TSLP production through the attenuation of caspase-1 activation in an animal model of allergic rhinitis by Naju Jjok (Polygonum tinctorium)

Hyun-Ja Jeong, Hyun-A Oh, Byung-Joo Lee, Hyung-Min Kim
Pages: 142-150
Published online on: 05 November 2013

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Article

Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells Corrigendum in /10.3892/ijmm.2025.5591

Pei Zhang, Hao Liu, Fei Xia, Qian Wen Zhang, Yuan Yuan Zhang, Qing  Zhao, Zhen Hua Chao, Zhi Wen Jiang, Chen Chen Jiang
Pages: 151-159
Published online on: 30 October 2013

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Article

Evaluation of the effects of different culture media on the myogenic differentiation potential of adipose tissue- or bone marrow-derived human mesenchymal stem cells

Jens Stern-Straeter, Gabriel Alejandro Bonaterra, Stephanie Juritz, Richard Birk, Ulrich Reinhart Goessler, Karen Bieback, Peter Bugert, Johannes Schultz, Karl Hörmann, Ralf Kinscherf, Anne Faber
Pages: 160-170
Published online on: 13 November 2013

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Article

Recombinant AAV-PR39-mediated hypoxia-inducible factor 1α gene expression attenuates myocardial infarction

Lijun Sun, Yuewen Hao, Xiaowei Nie, Jian Xu, Zhenwu Li, Wei Zhang, Ying Liu, Xuexin Zhang
Pages: 171-177
Published online on: 19 November 2013

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Article

Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation

Kyungho Park, Won-Chul Ju, Joo-Hong Yeo, Jong Youl Kim, Ho Seong Seo, Yoshikazu Uchida, Yunhi Cho
Pages: 178-184
Published online on: 18 November 2013

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Article

Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression

Seunghee Bae, Eun-Jin Lee, Jae  Ho Lee, In-Chul Park, Su-Jae Lee, Hyung Jin Hahn, Kyu Joong Ahn, Sungkwan An, In-Sook An, Hwa Jun Cha
Pages: 185-193
Published online on: 19 November 2013

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Article

P7 peptides targeting bFGF sensitize colorectal cancer cells to CPT-11

Wu Luo, Yonglin Yu, Ruixue Wang, Dan He, Cong Wang, Xiangfeng Zeng, Xilei Chen, Xiangpeng Tan, Tao Huang, Xiaoping Wu
Pages: 194-200
Published online on: 04 November 2013

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Article

Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy

Hui Li, Xue Yang, Wei Shi, Zhao Ma, Guangshen Feng, Qinzhou Wang, Li Shen, Chunli Xie
Pages: 201-208
Published online on: 30 October 2013

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Article

A novel ribonuclease with antiproliferative activity toward leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina

Rui  Zhang, Liyan  Zhao, Hexiang  Wang, Tzi  Bun Ng
Pages: 209-214
Published online on: 12 November 2013

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Article

In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent

Yuping Yang, Kaichao Yu, Hailu Zhang, Jianwu Dai, Zongwu Deng
Pages: 215-220
Published online on: 07 November 2013

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Article

Effects of octylphenol on the expression of cell cycle-related genes and the growth of mesenchymal stem cells derived from human umbilical cord blood

Hye-Rim Lee, Tae-Hee Kim, Kelvin J. Choi, Kyung-Chul Choi
Pages: 221-226
Published online on: 14 November 2013

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Article

Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms

Xizhong Sui, Changqing Gao
Pages: 227-233
Published online on: 01 November 2013

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Article

Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus

Jingang Hou, Jianjie Xue, Mira Lee, Jiaojiao Yu, Changkeun Sung
Pages: 234-240
Published online on: 08 November 2013

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Review Open Access

Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Review Open Access

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Article Open Access

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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Review Open Access

A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Review Open Access

Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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