Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus

  • Authors:
    • Jingang Hou
    • Jianjie Xue
    • Mira Lee
    • Jiaojiao Yu
    • Changkeun Sung
  • View Affiliations

  • Published online on: November 8, 2013     https://doi.org/10.3892/ijmm.2013.1552
  • Pages: 234-240
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ginsenosides, the secondary plant metabolites produced by Panax ginseng are responsible for the enhancing effects on learning observed following treatment with Panax ginseng. A number of studies have provided correlational evidence that cell proliferation and survival are closely associated with hippocampal-dependent learning tasks. In this study, to investigate the beneficial effects of ginsenoside Rh1 on hippocampal cells and learning, mice (6 months old) were administered ginsenoside Rh1 at a dose of 5 and 10 mg/kg/day for a period of 3 months. Saline-treated mice were used as controls. The enhancement of memory and learning in the mice was evaluated by hippocampal-dependent tasks (passive avoidance tests and Morris water maze tests) and the immunohistochemical marker of cell proliferation, bromodeoxyuridine (BrdU). In addition, the levels of brain-derived neurotrophic factor (BDNF) were measured following treatment. Based on our data, the Rh1-treated group (5 and 10 mg/kg) showed a significantly improved learning and memory ability in the passive avoidance tests compared with the control group; however, only treatment with 10 mg/kg ginsenoside Rh1 significantly promoted spatial learning ability in the Morris water maze test. Ginsenoside Rh1 significantly enhanced cell survival in the dentate gyrus of mice, although it did not enhance hippocampal cell proliferation. In addition, ginsenoside Rh1 upregulated the expression of BDNF. These findings address the potential therapeutic significance of ginsenoside Rh1 as a nutritional supplement in memory loss and neurodegenerative diseases.
View Figures
View References

Related Articles

Journal Cover

2014-January
Volume 33 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

The Cancer Story
Copy and paste a formatted citation
x
Spandidos Publications style
Hou J, Xue J, Lee M, Yu J and Sung C: Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. Int J Mol Med 33: 234-240, 2014
APA
Hou, J., Xue, J., Lee, M., Yu, J., & Sung, C. (2014). Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. International Journal of Molecular Medicine, 33, 234-240. https://doi.org/10.3892/ijmm.2013.1552
MLA
Hou, J., Xue, J., Lee, M., Yu, J., Sung, C."Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus". International Journal of Molecular Medicine 33.1 (2014): 234-240.
Chicago
Hou, J., Xue, J., Lee, M., Yu, J., Sung, C."Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus". International Journal of Molecular Medicine 33, no. 1 (2014): 234-240. https://doi.org/10.3892/ijmm.2013.1552