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Review

Paracrine control of glucagon release by somatostatin (Review)

  • Authors:
    • Willy J. Malaisse
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Université Libre de Bruxelles, B-1070 Brussels, Belgium
  • Pages: 491-498
    |
    Published online on: December 24, 2013
       https://doi.org/10.3892/ijmm.2013.1605
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Abstract

Emphasis was recently placed on the modulation of glucagon secretion attributable to a paracrine effect of somatostatin. This review draws attention to prior findings related to such a view. The effects of nutrient secretagogues upon insulin, somatostatin and glucagon release by the perfused pancreas are first considered. Three examples of paradoxical secretory responses of insulin- and glucagon-producing cells are then given. Further experiments dealing with the possible role of somatostatin upon glucagon release and the relevance of pancreatic compartmentation are also presented. It is concluded that these prior findings provide, within limits, support to the postulated paracrine role of somatostatin in the control of glucagon secretion.
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11 

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18 

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19 

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20 

Leclercq-Meyer V, Marchand J and Malaisse WJ: An arginine-like effect of the ‘fumarate + glutamate + pyruvate’ mixture on glucagon release. Life Sci. 20:1193–1198. 1997.

21 

Leclercq-Meyer V, Akkan AG, Marchand J and Malaisse WJ: Effects of glimepiride and glibenclamide on insulin and glucagon secretion by the perfused rat pancreas. Biochem Pharmacol. 42:1634–1637. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Leclercq-Meyer V and Malaisse WJ: Opposite effects of D-glucose and 2-ketoisocaproate upon insulin release by the isolated perfused pancreas removed from hyperglycemic rats. Endocrine J. 2:265–271. 1994.

23 

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24 

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25 

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26 

Leclercq-Meyer V, Marchand J, Leclercq R and Malaisse WJ: Calcium deprivation enhances glucagon release in the presence of 2-ketoisocaproate. Endocrinology. 108:2093–2097. 1981. View Article : Google Scholar : PubMed/NCBI

27 

Leclercq-Meyer V, Kadiata MM and Malaisse WJ: Effects of D-mannoheptulose and its hexaacetate ester on hormonal secretion from the perfused pancreas. Int J Mol Med. 6:143–152. 2000.PubMed/NCBI

28 

Leclercq-Meyer V, Kadiata MM and Malaisse WJ: Stimulation by 2-deoxy-D-glucose tetraacetates of hormonal secretion from the perfused rat pancreas. Am J Physiol. 276:E689–E696. 1999.PubMed/NCBI

29 

Sener A, Leclercq-Meyer V and Malaisse WJ: Immediate and delayed effects of D-fructose upon insulin, somatostatin, and glucagon release by the perfused rat pancreas. Endocrine. 24:73–81. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Leclercq-Meyer V and Malaisse WJ: Dual mode of action of glucose pentaacetates on hormonal secretion from the isolated perfused rat pancreas. Am J Physiol. 275:E610–E617. 1998.PubMed/NCBI

31 

Leclercq-Meyer V, Ladrière L, Fuhlendorff J and Malaisse WJ: Stimulation of insulin and somatostatin release by two meglitinide analogs. Endocrine. 7:311–317. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Leclercq-Meyer V, Marchand J and Malaisse WJ: Insulin and glucagon release from the ventral and dorsal parts of the perfused pancreas of the rat. Effects of glucose, arginine, glucagon and carbamylcholine. Horm Res. 21:19–32. 1985. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Malaisse WJ: Paracrine control of glucagon release by somatostatin (Review). Int J Mol Med 33: 491-498, 2014.
APA
Malaisse, W.J. (2014). Paracrine control of glucagon release by somatostatin (Review). International Journal of Molecular Medicine, 33, 491-498. https://doi.org/10.3892/ijmm.2013.1605
MLA
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33.3 (2014): 491-498.
Chicago
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33, no. 3 (2014): 491-498. https://doi.org/10.3892/ijmm.2013.1605
Copy and paste a formatted citation
x
Spandidos Publications style
Malaisse WJ: Paracrine control of glucagon release by somatostatin (Review). Int J Mol Med 33: 491-498, 2014.
APA
Malaisse, W.J. (2014). Paracrine control of glucagon release by somatostatin (Review). International Journal of Molecular Medicine, 33, 491-498. https://doi.org/10.3892/ijmm.2013.1605
MLA
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33.3 (2014): 491-498.
Chicago
Malaisse, W. J."Paracrine control of glucagon release by somatostatin (Review)". International Journal of Molecular Medicine 33, no. 3 (2014): 491-498. https://doi.org/10.3892/ijmm.2013.1605
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