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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
2014-March Volume 33 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Paracrine control of glucagon release by somatostatin (Review)

Willy J. Malaisse
Pages: 491-498
Published online on: 24 December 2013

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Article Open Access

Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin‑induced apoptosis and I/R through the upregulation of p-eIF2α

Chun-Lei Liu, Yun-Yun He, Xin Li, Rui-Jun Li, Kun-Lun He, Li-Li Wang
Pages: 499-506
Published online on: 23 December 2013

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Article Open Access

Differential expression and regulation of prohibitin during curcumin-induced apoptosis of immortalized human epidermal HaCaT cells

Hai-Bo Yang, Wei Song, Lan-Ying Chen, Qi-Fu Li, Song-Lin Shi, Hai-Yan Kong, Pu Chen
Pages: 507-514
Published online on: 09 January 2014

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Article Open Access

Human single-chain variable fragment antibody inhibits macrophage migration inhibitory factor tautomerase activity

Mayuri Tarasuk, Ornnuthchar Poungpair, Duangporn Ungsupravate, Kunan Bangphoomi, Wanpen Chaicumpa, Pa-Thai Yenchitsomanus
Pages: 515-522
Published online on: 13 January 2014

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Article Open Access

Enhancement in efferocytosis of oxidized low‑density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy

Baoxin Liu, Buchun Zhang, Rong Guo, Shuang Li, Yawei Xu
Pages: 523-533
Published online on: 27 December 2013

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Article Open Access

PDGF-induced PI3K-mediated signaling enhances the TGF‑β‑induced osteogenic differentiation of human mesenchymal stem cells in a TGF-β-activated MEK-dependent manner

Jun Yokota, Naoyuki Chosa, Shunsuke Sawada, Naoto Okubo, Noriko Takahashi, Tomokazu Hasegawa, Hisatomo Kondo, Akira Ishisaki
Pages: 534-542
Published online on: 27 December 2013

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Article Open Access

A novel assay for high-throughput screening of anti-Alzheimer's disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation

Xue-Qin Hou, Rong Yan, Cong Yang, Lei Zhang, Ru-Yu Su, Si-Jun Liu, Shi-Jie Zhang, Wen-Qing He, Shu-Huan Fang, Shu-Yi Cheng, Zi-Ren Su, Yun-Bo Chen, Qi Wang
Pages: 543-549
Published online on: 27 December 2013

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Article

17β-estradiol promotes cholesterol efflux from vascular smooth muscle cells through a liver X receptor α-dependent pathway

Huan Wang, Yan Liu, Ling Zhu, Wenjing Wang, Zhaofei Wan, Fangyuan Chen, Yan Wu, Juan Zhou, Zuyi Yuan
Pages: 550-558
Published online on: 08 January 2014

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Article

Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71

Tatsuya Segawa, Yoshihiro Fujii, Aya Tanaka, Shin-Ichi Bando, Ryuichi Okayasu, Ken Ohnishi, Nobuo Kubota
Pages: 559-564
Published online on: 19 December 2013

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Article

Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRβ in a ligand-independent manner in mesenchymal stem cells

Emiko Aomatsu, Naoyuki Chosa, Soko Nishihira, Yoshiki Sugiyama, Hiroyuki Miura, Akira Ishisaki
Pages: 565-572
Published online on: 27 December 2013

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Article

Nardostachys chinensis induces the differentiation of human promyelocytic leukemic cells through the activation of the protein kinase C-dependent extracellular signal-regulated kinase signaling pathway

Sung-Min Ju, Jun-Gue Kang, Hyun-Ock Pae, Guem-San Lee, Won-Sin Kim, Yeoung-Su Lyu, Byung-Hun Jeon
Pages: 573-580
Published online on: 19 December 2013

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Article

Revealing the molecular mechanism of colorectal cancer by establishing LGALS3‑related protein-protein interaction network and identifying signaling pathways

Lu Han, Zhixiong Wu, Qicheng Zhao
Pages: 581-588
Published online on: 08 January 2014

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Article

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis

Zhen Liu, Jun Zhang, Lijun Wu, Jie Liu, Mingqing Zhang
Pages: 589-596
Published online on: 20 December 2013

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Article

Neuroprotective effects of Gua Lou Gui Zhi decoction against glutamate-induced apoptosis in BV-2 cells

Zuanfang Li, Haixia Hu, Ruhui Lin, Jingjie Mao, Xiaoqin Zhu, Zhenfeng Hong, Jing Tao, Yun Zhang, Lidian Chen
Pages: 597-604
Published online on: 30 December 2013

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Article

Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells

Jingfu Chen, Hailiang Mo, Runmin Guo, Qiong You, Ruina Huang, Keng Wu
Pages: 605-612
Published online on: 07 January 2014

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Article

Expression of selected genes involved in steroidogenesis in the course of enucleation-induced rat adrenal regeneration

Marianna Tyczewska, Marcin Rucinski, Agnieszka Ziolkowska, Marcin Trejter, Marta Szyszka, Ludwik K. Malendowicz
Pages: 613-623
Published online on: 20 December 2013

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Article

O-GlcNAcylation under hypoxic conditions and its effects on the blood-retinal barrier in diabetic retinopathy

Chong Xu, Guodong Liu, Xiaoqiao Liu, Fang Wang
Pages: 624-632
Published online on: 20 December 2013

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Article

Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma

Heng Wang, Qing Feng Luo, Ai Fen Peng, Xin Hua Long, Tao Fang Wang, Zhi Li Liu, Guo Mei Zhang, Rong Ping Zhou, Song Gao, Yang Zhou, Wen Zhao Chen
Pages: 633-639
Published online on: 23 December 2013

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Article

Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes

Ghang Tai Lee, Hwa Jun Cha, Kwang Sik Lee, Kun Kook Lee, Jin Tae Hong, Kyu Joong Ahn, In-Sook An, Sungkwan An, Seunghee Bae
Pages: 640-648
Published online on: 07 January 2014

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Article

Phytosphigosine-1-phosphate increases sensitivity of EGF-dependent cell proliferation

Hwa Jun Cha, Jeong Pyo Lee, Kwang Sik Lee, Kun Kook Lee, Myoung Jun Choi, Dong Kyu Lee, Kwang Nyeon Kim, Sungkwan An
Pages: 649-653
Published online on: 07 January 2014

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Article

A novel GATA4 loss-of-function mutation responsible for familial dilated cardiomyopathy

Lan Zhao, Jia-Hong Xu, Wen-Jun Xu, Hong Yu, Qian Wang, Hong-Zhen Zheng, Wei-Feng Jiang, Jin-Fa Jiang, Yi-Qing Yang
Pages: 654-660
Published online on: 23 December 2013

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Article

Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability

Ying Yu, Jun Qin, Meizhen Liu, Qingyuan Ruan, Yiliang Li, Zhaohui Zhang
Pages: 661-669
Published online on: 07 January 2014

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Article

Transcriptome and miRNA network analysis of familial hypercholesterolemia

Haibin Chen, Liang Wang, Jinfa Jiang
Pages: 670-676
Published online on: 27 December 2013

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Article

Expression of retinoic acid target genes in coronary artery disease

Dusan Bilbija, Ali Ateia Elmabsout, Julia Sagave, Fred Haugen, Nasser Bastani, Christen Peder Dahl, Lars Gullestad, Allan Sirsjö, Rune Blomhoff, Guro Valen
Pages: 677-686
Published online on: 13 January 2014

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Article

Caffeic acid phenethyl ester attenuates pro-inflammatory and fibrogenic phenotypes of LPS-stimulated hepatic stellate cells through the inhibition of NF-κB signaling

Wen-Xing Zhao, Li Wang, Ju-Lun Yang, Lian-Zhen Li, Wen-Mang Xu, Tao Li
Pages: 687-694
Published online on: 30 December 2013

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Article

UVB-induced anti-survival and pro-apoptotic effects on HaCaT human keratinocytes via caspase- and PKC-dependent downregulation of PKB, HIAP-1, Mcl-1, XIAP and ER stress

Yu-Kyoung Park, Byeong-Churl Jang
Pages: 695-702
Published online on: 19 December 2013

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Article

Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells

Yongxun Zhao, Yumin Li, Jian Han, Tao Liu, Quanlin Guan, Peng Zhao, Lingyun Guo, Kaikun Liu, Dongqiang He
Pages: 703-710
Published online on: 07 January 2014

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Article

Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis

Fuliang Bai, Hui Tian, Zeshan Niu, Mingyao Liu, Guiping Ren, Yinhang Yu, Tian Sun, Siming Li, Deshan Li
Pages: 711-721
Published online on: 27 December 2013

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Article

RhoBTB2 gene in breast cancer is silenced by promoter methylation

Weiwei Tang, Chuan Wang, Fangmeng Fu, Qiang Chen
Pages: 722-728
Published online on: 18 December 2013

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Article

Comparison of read-through effects of aminoglycosides and PTC124 on rescuing nonsense mutations of HERG gene associated with long QT syndrome

Haiyun Yu, Xiaoyan Liu, Jian Huang, Yinhui Zhang, Roumu Hu, Jielin Pu
Pages: 729-735
Published online on: 23 December 2013

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Article

Formation of a salsolinol-like compound, the neurotoxin, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, in a cellular model of hyperglycemia and a rat model of diabetes

De-Wei Song, Nian Xin, Bing-Jie Xie, Yu-Juan Li, Ling-Yan Meng, Hong-Mei Li, Michael Schläppi, Yu-Lin Deng
Pages: 736-742
Published online on: 24 December 2013

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Review Open Access

Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Review Open Access

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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