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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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2014-April Volume 33 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

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Article

MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway

  • Authors:
    • Jian Zhou
    • Shiduo Song
    • Songbing He
    • Xinguo Zhu
    • Yi Zhang
    • Bin Yi
    • Bing Zhang
    • Gongzhao Qin
    • Dechun Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Gynaecology and Obstetrics, Suzhou Municipal Hospital, Suzhou, Jiangsu 215003, P.R. China
  • Pages: 950-956
    |
    Published online on: January 28, 2014
       https://doi.org/10.3892/ijmm.2014.1638
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Abstract

MicroRNAs (miRNAs or miRs) are believed to have great potential for use as molecular targets in the diagnosis and treatment of cancer. In this study, we demonstrate that miR-375 is downregulated in pancreatic carcinoma (PC) tissues and PC cell lines. We found that miR-375 negatively regulates the expression of 3-phosphoinositide-dependent protein kinase 1 (PDK1) by directly targeting the 3'UTR of the PDK1 transcript. To investigate the biological roles and the potential mechanisms of action of miR‑375, we induced either the up- or downregulation of miR-375 expression by transfecting various PC cells with miR-375 mimics or an inhibitor. Our results revealed that the upregulation of miR-375 inhibited cell growth and induced cell apoptosis, while the downregulation of miR-375 with the inhibitor had the opposite effect. In addition, our data demonstrate that miR-375 suppresses the malignant behavior of PC cells through the Akt signaling pathway rather than mitogen-activated protein kinase (MAPK) signaling pathways. Taken together, our findings indicate that targeting miR-375 by a genetic approach may provide a novel strategy for the treatment of PC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Song S, He S, Zhu X, Zhang Y, Yi B, Zhang B, Qin G and Li D: MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. Int J Mol Med 33: 950-956, 2014.
APA
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B. ... Li, D. (2014). MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. International Journal of Molecular Medicine, 33, 950-956. https://doi.org/10.3892/ijmm.2014.1638
MLA
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B., Zhang, B., Qin, G., Li, D."MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway". International Journal of Molecular Medicine 33.4 (2014): 950-956.
Chicago
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B., Zhang, B., Qin, G., Li, D."MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway". International Journal of Molecular Medicine 33, no. 4 (2014): 950-956. https://doi.org/10.3892/ijmm.2014.1638
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Song S, He S, Zhu X, Zhang Y, Yi B, Zhang B, Qin G and Li D: MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. Int J Mol Med 33: 950-956, 2014.
APA
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B. ... Li, D. (2014). MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway. International Journal of Molecular Medicine, 33, 950-956. https://doi.org/10.3892/ijmm.2014.1638
MLA
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B., Zhang, B., Qin, G., Li, D."MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway". International Journal of Molecular Medicine 33.4 (2014): 950-956.
Chicago
Zhou, J., Song, S., He, S., Zhu, X., Zhang, Y., Yi, B., Zhang, B., Qin, G., Li, D."MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway". International Journal of Molecular Medicine 33, no. 4 (2014): 950-956. https://doi.org/10.3892/ijmm.2014.1638
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