Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells

  • Authors:
    • Xiehua Xue
    • Tong Chen
    • Wei Wei
    • Xiaomao Zhou
    • Zhicheng Lin
    • Lidian Chen
  • View Affiliations / Copyright

    Affiliations: Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China, College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P.R. China
  • Pages: 971-977
    |
    Published online on: February 6, 2014
       https://doi.org/10.3892/ijmm.2014.1646
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The liver X receptor α (LXRα)/ATP-binding cassette transporter A1 (ABCA1) pathway and LXR-modulated cytokines play an important role in macrophages which mediate lipid engulfment and the inflammatory response, and participate in the process of atherosclerosis. Therefore, lipid-lowering and anti-inflammatory therapy through the activation of the LXRα/ABCA1 pathway and LXRα-modulated cytokines may prove to be one of the main treatment strategies for atherosclerosis. Alisma Decoction (AD) has long been used in China to clinically treat cardiovascular and cerebral diseases; however, the precise mechanisms involved remain to be elucidated. In the present study, we evaluated the regulation of lipids and the anti-inflammatory effects exerted by AD and investigated the underlying molecular mechanisms using oxidized low-density lipoprotein (ox-LDL)-stimulated foam cells derived from rat peritoneal macrophages. We first found that AD markedly relieved lipid deposition in foam cells as it increased LXRα and ABCA1 expression and decreased the ox-LDL-induced expression of inflammatory cytokines, such as matrix metalloproteinase-9 and interleukin-1β. Collectively, our findings suggest that blocking lipid deposition and inhibiting inflammatory response through the activation of the LXRα pathway may be one of the main mechanisms through which AD exerts its anti-atherosclerotic effects.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Lusis AJ: Atherosclerosis. Nature. 407:233–241. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Bonamassa B and Moschetta A: Atherosclerosis: lessons from LXR and the intestine. Trends Endocrinol Metab. 24:120–128. 2013. View Article : Google Scholar : PubMed/NCBI

3 

van Diepen JA, Berbée JF, Havekes LM and Rensen PC: Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis. 228:306–315. 2013.PubMed/NCBI

4 

Venkateswaran A, Laffitte BA, Joseph SB, et al: Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci USA. 97:12097–12102. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Zelcer N and Tontonoz P: Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 116:607–614. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Edwards PA, Kennedy MA and Mak PA: LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vascul Pharmacol. 38:249–256. 2002.PubMed/NCBI

7 

Castrillo A, Joseph SB, Marathe C, et al: Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 278:10443–10449. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Giannarelli C, Cimmino G, Connolly TM, et al: Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atheroselerosis. Eur Heart J. 33:264–273. 2012. View Article : Google Scholar

9 

Calkin AC and Tontonoz P: Liver x receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol. 30:1513–1518. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Liv J: The efficacy evaluation of Alisma Decoction assiting on western medicine treating essential hypertension. Shi Yong Yao Wu Yu Lin Chuang. 16:629–630. 2013.(In Chinese).

11 

Liv S, Cao K and Wang P: Alisma Decoction treating hyperlipidemia by 120 Cases. Zhong Yi Yao Lin Chuang Za Zhi. 17:4542005.(In Chinese).

12 

Tang X, Zhai Y and Liu T: The effect of Alisma Decoction on hemorheology and serum nitric oxide on experimental hyperlipidemia rats. Zhong Guo Shi Yan Fang Ji Xue Za Zhi. 12:26–28. 2006.(In Chinese).

13 

Steinberg D: Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med. 8:1211–1217. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Glass CK and Witztum JL: Atherosclerosis. The road ahead. Cell. 104:503–516. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Jiang Y, Wang M, Huang K, et al: Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Biochem Biophys Res Commun. 425:121–126. 2012.

16 

Repa JJ, Turley SD, Lobaccaro JA, et al: Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 289:1524–1529. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Hong C and Tontonoz P: Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Curr Opin Genet Dev. 18:461–467. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ and Tontonoz P: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 9:213–219. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Qian Y and Ni Z: The effect of liver X receptors in metabolism and inflammation. Lin Chuang Xin Xue Guan Bing Za Zhi. 23:806–810. 2007.(In Chinese).

20 

Parks WC and Shapiro SD: Matrix metalloproteinases in lung biology. Respir Res. 2:10–19. 2001. View Article : Google Scholar

21 

Ferretti G, Bacchetti T, Marotti E and Curatola G: Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity. Metabolism. 52:146–151. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Fang L, Du XJ, Gao XM and Dart AM: Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene pro file in acute myocardial infarction. Clin Sci (Lond). 119:175–183. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Halade GV, Jin YF and Lindsey ML: Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation. Pharmacol Ther. 139:32–40. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Krex D, Schachert HK and Schackert G: Genesis of cerebral aneurysms - an update. Acta Neurochir (Wien). 143:429–449. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Sigala F, Kotsinas A, Savari P, et al: Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability. J Vasc Surg. 52:704–713. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Huang Y, Mironova M and Lopes-Virella MF: Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 19:2640–2647. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Moyer CF, Sajuthi D, Tulli H and Williams JK: Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am J Pathol. 138:951–960. 1991.PubMed/NCBI

28 

Tipping PG and Hancock WW: Production of tumor necrosis factor and interleukin-1 by macrophages from human atheromatous plaques. Am J Pathol. 142:1721–1728. 1993.PubMed/NCBI

29 

Church LD, Cook GP and McDermott MF: Primer: inflammasomes and interleukin 1beta in inflammatory disorders. Nat Clin Pract Rheumatol. 4:34–42. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Dinarello CA: Anti-inflammatory agents: present and future. Cell. 140:935–950. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Rader DJ: IL-1 and atherosclerosis: a murine twist to an evolving human story. J Clin Invest. 122:27–30. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Kirii H, Niwa T and Yamada Y: Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 23:656–660. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Dinarello CA: Biologic basis for interleukin-1 in disease. Blood. 87:2095–2147. 1996.PubMed/NCBI

34 

Ku G, Thomas CE, Akeson AL and Jackson RL: Induction of interleukin 1beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem. 267:14183–14188. 1992.PubMed/NCBI

35 

Naik SU, Wang X, Da Silva JS, et al: Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation. 113:90–97. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Chawla A, Boisvert WA, Lee CH, et al: A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 7:161–171. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Guo ZG, Wu PS, Li JH and Lai WY: Modulation of inflammatory cytokines by ATP-binding cassette A1 in THP-1 macrophages. Nan Fang Yi Ke Da Xue Xue Bao. 26:1269–1271. 2006.(In Chinese).

38 

Li J, Yang Y, Hao P and Guo Z: ABCA1 regulating on inflammatory cytokines and its significance on vascular smooth muscle cells. Shi Yong Yi Xue Za Zhi. 26:1713–1716. 2010.(In Chinese).

39 

Yin K, Liao DF and Tang CK: ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport. Mol Med. 16:438–449. 2010.PubMed/NCBI

40 

Reddy ST, Hama S, Ng C, Grijalva V, Navab M and Fogelman AM: ATP-binding cassette transporter-1 participates in LDL Oxidation by artery wall cells. Arterioscler Thromb Vasc Biol. 22:1877–1883. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Zhou X, Yin Z, Guo X, Hajjar DP and Han J: Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux. J Biol Chem. 285:6316–6326. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xue X, Chen T, Wei W, Zhou X, Lin Z and Chen L: Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells. Int J Mol Med 33: 971-977, 2014.
APA
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., & Chen, L. (2014). Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells. International Journal of Molecular Medicine, 33, 971-977. https://doi.org/10.3892/ijmm.2014.1646
MLA
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., Chen, L."Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells". International Journal of Molecular Medicine 33.4 (2014): 971-977.
Chicago
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., Chen, L."Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells". International Journal of Molecular Medicine 33, no. 4 (2014): 971-977. https://doi.org/10.3892/ijmm.2014.1646
Copy and paste a formatted citation
x
Spandidos Publications style
Xue X, Chen T, Wei W, Zhou X, Lin Z and Chen L: Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells. Int J Mol Med 33: 971-977, 2014.
APA
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., & Chen, L. (2014). Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells. International Journal of Molecular Medicine, 33, 971-977. https://doi.org/10.3892/ijmm.2014.1646
MLA
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., Chen, L."Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells". International Journal of Molecular Medicine 33.4 (2014): 971-977.
Chicago
Xue, X., Chen, T., Wei, W., Zhou, X., Lin, Z., Chen, L."Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRα pathway in macrophage-derived foam cells". International Journal of Molecular Medicine 33, no. 4 (2014): 971-977. https://doi.org/10.3892/ijmm.2014.1646
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team