Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-April Volume 33 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

The plasminogen activation system in periodontal tissue (Review)

  • Authors:
    • Marzena Wyganowska-Świątkowska
    • Anna Surdacka
    • Ewa Skrzypczak-Jankun
    • Jerzy Jankun
  • View Affiliations / Copyright

    Affiliations: Department of Conservative Dentistry and Periodontology, Poznań University of Medical Sciences, Poznań 60-820, Poland, Urology Research Center, Department of Urology, College of Medicine, University of Toledo, Toledo, OH 43614, USA, Protein Research Chair, Department of Biochemistry, College of Sciences, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
  • Pages: 763-768
    |
    Published online on: February 10, 2014
       https://doi.org/10.3892/ijmm.2014.1653
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The plasminogen activation system (PAS) plays an essential role in tissue proteolysis in physiological and pathological processes. Periodontitis is a chronic infection associated with increased proteolysis driven by plasminogen activation. In this comprehensive review, we summarise the effects of PAS in wound healing, tissue remodelling, inflammation, bacterial infection, and in the initiation and progression of periodontal disease. Specifically, we discuss the role of plasminogen activators (PAs), including urokinase PA (uPA), tissue-type PA (tPA), PA inhibitor type 1 (PAI-1) and 2 (PAI-2) and activated plasminogen in periodontal tissue, where their concentrations can reach much higher values than those found in other parts of the body. We also discuss whether PA deficiencies can have effects on periodontal tissue. We conclude that in periodontal disease, PAS is unbalanced and equalizing its function can improve the clinical periodontal tissue condition.
View Figures

Figure 1

Figure 2

View References

1 

Conese M and Blasi F: The urokinase/urokinase-receptor system and cancer invasion. Baillieres Clin Haematol. 8:365–389. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Rakic JM, Maillard C, Jost M, et al: Role of plasminogen activator-plasmin system in tumor angiogenesis. Cell Mol Life Sci. 60:463–473. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Slot O, Brünner N, Locht H, Oxholm P and Stephens RW: Soluble urokinase plasminogen activator receptor in plasma of patients with inflammatory rheumatic disorders: increased concentrations in rheumatoid arthritis. Ann Rheum Dis. 58:488–492. 1999. View Article : Google Scholar

4 

Stoppelli MP, Tacchetti C, Cubellis MV, et al: Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell. 45:675–684. 1986. View Article : Google Scholar : PubMed/NCBI

5 

Lijnen HR, Maquoi E, Hansen LB, Van Hoef B, Frederix L and Collen D: Matrix metalloproteinase inhibition impairs adipose tissue development in mice. Arterioscler Thromb Vasc Biol. 22:374–379. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Andreasen PA, Egelund R and Petersen HH: The plasminogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci. 57:25–40. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Andreasen PA, Kjøller L, Christensen L and Duffy MJ: The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer. 72:1–22. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Blasi F: uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today. 18:415–417. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Sitrin RG, Todd RF III, Albrecht E and Gyetko MR: The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J Clin Invest. 97:1942–1951. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Stefansson S and Lawrence DA: The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature. 383:441–443. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Ginsburg D, Zeheb R, Yang AY, et al: cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. J Clin Invest. 78:1673–1680. 1986. View Article : Google Scholar : PubMed/NCBI

12 

Chorostowska-Wynimko J, Skrzypczak-Jankun E and Jankun J: Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review). Int J Mol Med. 13:759–766. 2004.PubMed/NCBI

13 

Stefansson S, McMahon GA, Petitclerc E and Lawrence DA: Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling. Curr Pharm Des. 9:1545–1564. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Yamamoto K and Saito H: A pathological role of increased expression of plasminogen activator inhibitor-1 in human or animal disorders. Int J Hematol. 68:371–385. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Chorostowska-Wynimko J, Swiercz R, Skrzypczak-Jankun E, Wojtowicz A, Selman SH and Jankun J: A novel form of the plasminogen activator inhibitor created by cysteine mutations extends its half-life: relevance to cancer and angiogenesis. Mol Cancer Ther. 2:19–28. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Jankun J, Yang J, Zheng H, Han FQ, Al-Senaidy A and Skrzypczak-Jankun E: Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure. Int J Mol Med. 29:61–64. 2012.PubMed/NCBI

17 

Berkenpas MB, Lawrence DA and Ginsburg D: Molecular evolution of plasminogen activator inhibitor-1 functional stability. EMBO J. 14:2969–2977. 1995.PubMed/NCBI

18 

Tucker HM, Mottonen J, Goldsmith EJ and Gerard RD: Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Nat Struct Biol. 2:442–445. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Dano K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS and Skriver L: Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res. 44:139–266. 1985. View Article : Google Scholar : PubMed/NCBI

20 

Swiercz R, Keck RW, Skrzypczak-Jankun E, Selman SH and Jankun J: Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice. Oncol Rep. 8:463–470. 2001.PubMed/NCBI

21 

Swiercz R, Skrzypczak-Jankun E, Merrell MM, Selman SH and Jankun J: Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator. Oncol Rep. 6:523–526. 1999.PubMed/NCBI

22 

Jankun J, Aleem AM, Selman SH, et al: Highly stable plasminogen activator inhibitor type one (VLHL PAI-1) protects fibrin clots from tissue plasminogen activator-mediated fibrinolysis. Int J Mol Med. 20:683–687. 2007.PubMed/NCBI

23 

Jankun J, Aleem AM, Struniawski R, Lysiak-Szydlowska W, Selman SH and Skrzypczak-Jankun E: Accelerated thrombus lysis in the blood of plasminogen activator inhibitor deficient mice is inhibited by PAI-1 with a very long half-life. Pharmacol Rep. 61:673–680. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Klinghofer V, Stewart K, McGonigal T, et al: Species specificity of amidine-based urokinase inhibitors. Biochemistry. 40:9125–9131. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zeslawska E, Jacob U, Schweinitz A, Coombs G, Bode W and Madison E: Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors. J Mol Biol. 328:109–118. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Zhao G, Yuan C, Wind T, Huang Z, Andreasen PA and Huang M: Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1. J Struct Biol. 160:1–10. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Birn H and Fejerskov O: Fibrynolotic activity of human oral epithelial cells: A preliminary report. Scand J Dent Res. 79:381–386. 1971.PubMed/NCBI

28 

Moody GH: The source of plasminogen activator in human saliva. Archs Oral Biol. 27:33–37. 1982.PubMed/NCBI

29 

Schmid J, Cohen RL and Chambers DA: Plasminogen activator in human periodontal health and disease. Arch Oral Biol. 36:245–250. 1991. View Article : Google Scholar : PubMed/NCBI

30 

Bartold PM, Walsh LJ and Narayanan AS: Molecular and cell biology of the gingiva. Periodontol 2000. 24:28–55. 2000. View Article : Google Scholar

31 

Schafer BM, Maier K, Eickhoff U, Todd RF and Kramer MD: Plasminogen activation in healing human wounds. Am J Pathol. 144:1269–1280. 1994.PubMed/NCBI

32 

Xiao Y, Li H, Bunn C and Bartold PM: The expression of plasminogen activator system in a rat model of periodontal wound healing. J Periodontol. 72:849–857. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Schaefer BM, Maier K, Eickhoff U, Bechtel M and Kramer MD: alpha 2-Antiplasmin and plasminogen activator inhibitors in healing human skin wounds. Arch Dermatol Res. 288:122–128. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Thapa B, Kim YH, Kwon HJ and Kim DS: Novel regulatory mechanism and functional implication of plasminogen activator inhibitor-1 (PAI-1) expression in CpG-ODN-stimulated macrophages. Mol Immunol. 49:572–581. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Morimoto K, Mishima H, Nishida T and Otori T: Role of urokinase type plasminogen activator (u-PA) in corneal epithelial migration. Thromb Haemost. 69:387–391. 1993.PubMed/NCBI

36 

Abiko Y, Arai J, Matsuzawa K, Inoue T, Shimono M and Kaku T: Human gingival fibroblast migration promoted by platelet-derived growth factor on titanium is correlated with release of urokinase type plasminogen activator. Bull Tokyo Dent Coll. 37:113–118. 1996.PubMed/NCBI

37 

Horowitz JC, Rogers DS, Simon RH, Sisson TH and Thannickal VJ: Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis. Am J Respir Cell Mol Biol. 38:78–87. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Quigley JP, Gold LI, Schwimmer R and Sullivan LM: Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells. Proc Natl Acad Sci USA. 84:2776–2780. 1987. View Article : Google Scholar : PubMed/NCBI

39 

Feghali K and Grenier D: Priming effect of fibronectin fragments on the macrophage inflammatory response: potential contribution to periodontitis. Inflammation. 35:1696–1705. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Yee JA, Yan L, Dominguez JC, Allan EH and Martin TJ: Plasminogen-dependent activation of latent transforming growth factor beta (TGF beta) by growing cultures of osteoblast-like cells. J Cell Physiol. 157:528–534. 1993. View Article : Google Scholar : PubMed/NCBI

41 

Allan EH and Martin TJ: The plasminogen activator inhibitor system in bone cell function. Clin Orthop Relat Res. 313:54–63. 1995.PubMed/NCBI

42 

Daci E, Everts V, Torrekens S, et al: Increased bone formation in mice lacking plasminogen activators. J Bone Miner Res. 18:1167–1176. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Bartold PM: Periodontal tissues in health and disease: introduction. Periodontol 2000. 40:7–10. 2006. View Article : Google Scholar

44 

Bartold PM and Narayanan AS: Molecular and cell biology of healthy and diseased periodontal tissues. Periodontol 2000. 40:29–49. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Kinnby B, Lecander I, Martinsson G and Astedt BK: Tissue plasminogen activator and placental plasminogen activator inhibitor in human gingival fluid. Fibrinolysis. 5:239–242. 1991. View Article : Google Scholar

46 

Kinnby B, Matsson L and Lecander I: The plasminogen-activating system in gingival fluid from adults. An intra-individual study before and after treatment of gingivitis. Scand J Dent Res. 102:334–341. 1994.PubMed/NCBI

47 

Olofsson A, Lindberg P, Lanke J, Matsson L and Kinnby B: Relationship between fibrinolytic activity and gingival inflammatory reaction in young individuals. J Periodontal Res. 38:104–108. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Yin X, Bunn CL and Bartold PM: Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients. J Clin Periodontol. 27:149–156. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Olofsson A, Matsson L and Kinnby B: Plasminogen activating capacity in gingival fluid from deteriorating and stable periodontal pockets. J Periodontal Res. 37:60–65. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Kinnby B, Lindberg P, Lecander I and Matsson L: Localisation of plasminogen activator inhibitors in human gingival tissue demonstrated by immunochemistry and in situ hybridization. Arch Oral Biol. 44:1027–1034. 1999. View Article : Google Scholar : PubMed/NCBI

51 

Lindberg P, Kinnby B, Lecander I, Lang NP and Matsson L: Increasing expression of tissue plasminogen activator and plasminogen activator inhibitor type 2 in dog gingival tissues with progressive inflammation. Arch Oral Biol. 46:23–31. 2001. View Article : Google Scholar : PubMed/NCBI

52 

Papadimitriou S, Tsantarliotou M, Makris G, et al: A clinical study of plasminogen activator activity in gingival tissue in dogs with gingivitis and periodontitis. Res Vet Sci. 80:189–193. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Bizzarro S, van der Velden U, ten Heggeler JM, et al: Periodontitis is characterized by elevated PAI-1 activity. J Clin Periodontol. 34:574–580. 2007. View Article : Google Scholar

54 

De Taeye B, Smith LH and Vaughan DE: Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease. Curr Opin Pharmacol. 5:149–154. 2005.PubMed/NCBI

55 

Munford RS: Statins and the acute-phase response. N Engl J Med. 344:2016–2018. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Agis H, Bauer M, Knebl G, Watzek G and Gruber R: Effects of platelet-derived growth factor isoforms on plasminogen activation by periodontal ligament and gingival fibroblasts. J Periodontal Res. 43:334–342. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Haffajee AD and Socransky SS: Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 5:78–111. 1994. View Article : Google Scholar : PubMed/NCBI

58 

Uitto VJ, Larjava H, Heino J and Sorsa T: A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator. Infect Immun. 57:213–218. 1989.

59 

Oikawa T, Ogura N, Akiba M, Abiko Y, Takiguchi H and Izumi H: Stimulation of plasmin activity in cultured human fibroblast cells by Porphyromonas endodontalis. Int J Biochem. 25:1227–1231. 1993. View Article : Google Scholar : PubMed/NCBI

60 

Ogura N, Shibata Y, Matsuda U, et al: Effect of Campylobacter rectus LPS on plasminogen activator-plasmin system in human gingival fibroblast cells. J Periodontal Res. 30:132–140. 1995.

61 

Mochan E, Armor L and Sporer R: Interleukin 1 stimulation of plasminogen activator production in cultured gingival fibroblasts. J Periodontal Res. 23:28–32. 1988. View Article : Google Scholar : PubMed/NCBI

62 

Sarajlic J, Agis H, Kandler B, Watzek G and Gruber R: Plasminogen activation by fibroblasts from periodontal ligament and gingiva is not directly affected by chemokines in vitro. Arch Oral Biol. 52:663–668. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Birkedal-Hansen H: Role of matrix metalloproteinases in human periodontal diseases. J Periodontol. 64:474–484. 1993. View Article : Google Scholar : PubMed/NCBI

64 

Johnston KH: Solid and fluid phase assays for bacterial plasminogen activators. J Microbiol Methods. 18:267–274. 1993. View Article : Google Scholar

65 

Lottenberg R, Minning-Wenz D and Boyle MD: Capturing host plasmin(ogen): a common mechanism for invasive pathogens? Trends Microbiol. 2:20–24. 1994. View Article : Google Scholar : PubMed/NCBI

66 

Pantzar M, Ljungh A and Wadstrom T: Plasminogen binding and activation at the surface of Helicobacter pylori CCUG 17874. Infect Immun. 66:4976–4980. 1998.PubMed/NCBI

67 

Darenfed H, Grenier D and Mayrand D: Acquisition of plasmin activity by Fusobacterium nucleatum subsp nucleatum and potential contribution to tissue destruction during periodontitis. Infect Immun. 67:6439–6444. 1999.PubMed/NCBI

68 

Bennett KW and Eley A: Fusobacteria: new taxonomy and related diseases. J Med Microbiol. 39:246–254. 1993. View Article : Google Scholar : PubMed/NCBI

69 

Jankun J and Skrzypczak-Jankun E: Yin and yang of the plasminogen activator inhibitor. Pol Arch Med Wewn. 119:410–417. 2009.PubMed/NCBI

70 

Largent V, Deneys V, Brichard B, Chantrain C and Vermylen C: Bleeding diathesis in a child with normal screening tests: think about fibrinolysis. Eur J Pediatr. 164:587–588. 2005. View Article : Google Scholar : PubMed/NCBI

71 

Mehta R and Shapiro AD: Plasminogen activator inhibitor type 1 deficiency. Haemophilia. 14:1255–1260. 2008. View Article : Google Scholar : PubMed/NCBI

72 

Jankun J and Skrzypczak-Jankun E: Bleeding diathesis is associated with an A15T heterozygous mutation in exon 2 of the plasminogen activator inhibitor type 1. Exp Ther Med. 1:575–577. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Jankun J, Keck R, Selman SH and Skrzypczak-Jankun E: Systemic or topical application of plasminogen activator inhibitor with extended half-life (VLHL PAI-1) reduces bleeding time and total blood loss. Int J Mol Med. 26:501–504. 2010. View Article : Google Scholar : PubMed/NCBI

74 

El-Darouti M, Zayed AA, El-Kamah GY and Mostafa MI: Ligneous conjunctivitis with oral mucous membrane involvement and decreased plasminogen level. Pediatr Dermatol. 26:448–451. 2009. View Article : Google Scholar : PubMed/NCBI

75 

Lin Z, Jiang L, Yuan C, et al: Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem. 286:7027–7032. 2011. View Article : Google Scholar : PubMed/NCBI

76 

Zeslawska E, Schweinitz A, Karcher A, et al: Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 301:465–475. 2000. View Article : Google Scholar : PubMed/NCBI

77 

Brown NJ: Therapeutic potential of plasminogen activator inhibitor-1 inhibitors. Ther Adv Cardiovasc Dis. 4:315–324. 2010. View Article : Google Scholar : PubMed/NCBI

78 

Xue Y, Björquist P, Inghardt T, et al: Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide. Structure. 6:627–636. 1998. View Article : Google Scholar

79 

Mavri A, Alessi MC, Bastelica D, Geel-Georgelin O, et al: Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss. Diabetologia. 44:2025–2031. 2001. View Article : Google Scholar : PubMed/NCBI

80 

Ritchie CS: Obesity and periodontal disease. Periodontol 2000. 44:154–163. 2007. View Article : Google Scholar

81 

Saito T, Shimazaki Y, Koga T, et al: Relationship between periodontitis and hepatic condition in Japanese women. J Int Acad Periodontol. 8:89–95. 2006.PubMed/NCBI

82 

Staufenbiel I, Weinspach K, Förster G, et al: Periodontal condition in vegetarians: a clinical study. Eur J Clin Nutr. 67:836–840. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Tanaka K, Sasaki S, Murakami K, et al: Relationsip between soy and isoflavone intake and periodontal disesae: the freshmen in dietetic Courses Study II. BMC Public Health. 8:39–46. 2008. View Article : Google Scholar : PubMed/NCBI

84 

Smith PC, Santibañez JF, Morales JP and Martinez J: Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J Periodont Res. 39:380–387. 2004. View Article : Google Scholar

85 

Kushiyama M, Shimazaki Y, Murakami M and Yamashita Y: Relationship between intake of green tea and periodontal disease. J Periodontol. 80:372–377. 2009. View Article : Google Scholar : PubMed/NCBI

86 

Pasten C, Olave NC, Zhou L, et al: Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 121:59–65. 2007. View Article : Google Scholar

87 

Cho AR, Kim JH, Lee DE, et al: The effect of orally administrated epigallocatechin-3-gallate on ligature-induced periodontitis in rats. J Periodontol. 48:781–789. 2013.PubMed/NCBI

88 

Hosokawa Y, Hosokawa I, Shindo S, et al: (−)-Epigallocatechin-3-gallate inhibits CC chemokine ligand 11 production in human gingival fibroblasts. Cell Physiol Biochem. 31:960–967. 2013.

89 

Guimarães MR, Coimbra LS, de Aquino SG, et al: Potent anti-inflammatory effects of systemically administrated curcumin modulate periodontal disease in vivo. J Periodontal Res. 46:269–279. 2011.PubMed/NCBI

90 

Madhyastha R, Madhyastha H, Nakajima S, et al: Curcumin facilitates fibrynolysis and cellular migration during wound healing by modulation urokinase plasminogen activator expression. Pathophysiol Haemost Thromb. 37:59–66. 2010. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wyganowska-Świątkowska M, Surdacka A, Skrzypczak-Jankun E and Jankun J: The plasminogen activation system in periodontal tissue (Review). Int J Mol Med 33: 763-768, 2014.
APA
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., & Jankun, J. (2014). The plasminogen activation system in periodontal tissue (Review). International Journal of Molecular Medicine, 33, 763-768. https://doi.org/10.3892/ijmm.2014.1653
MLA
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., Jankun, J."The plasminogen activation system in periodontal tissue (Review)". International Journal of Molecular Medicine 33.4 (2014): 763-768.
Chicago
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., Jankun, J."The plasminogen activation system in periodontal tissue (Review)". International Journal of Molecular Medicine 33, no. 4 (2014): 763-768. https://doi.org/10.3892/ijmm.2014.1653
Copy and paste a formatted citation
x
Spandidos Publications style
Wyganowska-Świątkowska M, Surdacka A, Skrzypczak-Jankun E and Jankun J: The plasminogen activation system in periodontal tissue (Review). Int J Mol Med 33: 763-768, 2014.
APA
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., & Jankun, J. (2014). The plasminogen activation system in periodontal tissue (Review). International Journal of Molecular Medicine, 33, 763-768. https://doi.org/10.3892/ijmm.2014.1653
MLA
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., Jankun, J."The plasminogen activation system in periodontal tissue (Review)". International Journal of Molecular Medicine 33.4 (2014): 763-768.
Chicago
Wyganowska-Świątkowska, M., Surdacka, A., Skrzypczak-Jankun, E., Jankun, J."The plasminogen activation system in periodontal tissue (Review)". International Journal of Molecular Medicine 33, no. 4 (2014): 763-768. https://doi.org/10.3892/ijmm.2014.1653
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team